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While geothermal power is an attractive potential source for sustainable energy production, the high heat temperature requirements (typically >150?C) of most geothermal capture systems constrain geographic distribution and economic viability of geothermal energy production. Advancement of strategic material or mineral recovery aims to address this limitation. By partnering with geothermal and mineral industry stakeholders to develop additional revenue streams from brines, the economic viability of geothermal projects will increase while also allowing for increased geographic diversity of this clean, round-the-clock energy source. Rare earths and strategic minerals are essential for modern industry, especially clean-energy technologies, but are subject to supply risk in the face of ever-increasing demand. As an example, consumer uses of lithium batteries have soared over the last decade, powering everything from electric cars to tablets to cell phones. Global demand for lithium carbonate is expected to exceed 250,000 tons by 2017?a 60% increase over current usage. As demand grows in this burgeoning market, a reliable supply of critical materials for advanced manufacturing technologies is a growing concern. This program aims to help alleviate this type of supply bottleneck. The Energy Department seeks up to ten 1-2 year feasibility and/or applied R&D projects that will lead to commercialized technologies. Geothermal mining of rare earth and near-critical metals are the focus of this research, with the intent to effectively lower the cost of geothermal energy production while diversifying and stabilizing the supply of critical materials for domestic industries.

The lack of logistics systems capable of handling and delivering sufficiently high tonnage year-round volumes of high quality feedstocks to support the rapid escalation of cellulosic biofuels production has been identified as a significant barrier to the expansion of a sustainable domestic biofuels industry. In particular, biomass physical and chemical quality parameters have repeatedly been identified as significant challenges to the smooth operation and economic viability of biorefineries. This FOA will focus on developing and demonstrating strategies, equipment, and rapid analytical methods to manage feedstock quality within economic constraints throughout the feedstock supply chain. The main effort in Proposals must be directed toward full-scale demonstration of integrated feedstock supply chain systems that can deliver the volume of high quality, affordable, high impact feedstocks required by commercial biorefineries over a significant geographic area in the United States. DOE plans to support the increased production of high volumes of sustainably produced domestic biofuels from cellulosic feedstocks by seeking Proposals to design new systems or adapt existing systems to handle industrial scale volumes of cellulosic feedstocks from the harvest point to the throat of the biorefinery reactor.

One of JDRF's therapeutic goals is to restore beta cell function in type 1 diabetes (T1D) by replacement/transplantation of beta cells/islets. Pancreatic islet transplantation has been efficacious in selected patients in improving metabolic control and quality of life, and in preventing severe hypoglycemia in patients with medically unstable T1D. Despite improvements in cadaveric pancreas procurement, islet isolation, and islet purification, major scientific and technical challenges remain that must be addressed before beta cell replacement could be widely incorporated into the clinical management of established T1D; examples include serious side effects from chronic immunosuppression and the insufficient human islet supply from cadaveric pancreata. JDRF's role is to enable the scientific community to address these challenges with the ultimate goal of developing safe and effective beta cell replacement approaches available to large numbers of individuals with T1D.

One of JDRF's therapeutic goals is to restore beta cell function in type 1 diabetes (T1D) by replacement/transplantation of beta cells/islets. Pancreatic islet transplantation has been efficacious in selected patients in improving metabolic control and quality of life, and in preventing severe hypoglycemia in patients with medically unstable T1D. Despite improvements in cadaveric pancreas procurement, islet isolation, and islet purification, major scientific and technical challenges remain that must be addressed before beta cell replacement could be widely incorporated into the clinical management of established T1D; examples include serious side effects from chronic immunosuppression and the insufficient human islet supply from cadaveric pancreata. JDRF's role is to enable the scientific community to address these challenges with the ultimate goal of developing safe and effective beta cell replacement approaches available to large numbers of individuals with T1D.

NineSigma, representing a global industrial manufacturer, invites proposals for engineering services for design and prototype of rugged power supplies for industrial applications.

Major goals of NSF's D-ISN include: Improve understanding of the operations of illicit supply networks and strengthen the ability to detect, disrupt, and dismantle them. Enhance research communities that effectively integrate operational, computational, social, cultural and economic expertise to provide methods and strategies to combat this complex and elusive global security challenge. Catalyze game-changing technological innovations that can improve discovery and traceability of illicitly sourced products and illicitly sourced labor inputs to products. Provide research outcomes that inform U.S. national security, law enforcement and economic development needs and policies.

The goal of the Environmental Engineering program is tosupport transformative research which applies scientific and engineering principles to avoid or minimize solid, liquid, and gaseous discharges, resulting from human activities on land, inland and coastal waters, and air, while promoting resource and energy conservation and recovery. The program also fosters cutting-edge scientific research for identifying, evaluating, and monitoring the waste assimilative capacity of the natural environment and for removing or reducing contaminants from polluted air, water, and soils. Any proposal investigating sensors, materials or devices that does not integrate these products with an environmental engineering activity or area of research may be returned without review. Major areas of interest include: Enhancing the availability of high quality water supplies: Development of innovative biological, chemical and physical treatment processes to meet the growing demand for water; investigation of processes that remove and degrade contaminants, remediate contaminated soil and groundwater, and convert wastewaters into water suitable for reuse; investigation of environmental engineering aspects of urban watersheds, reservoirs, estuaries and storm water management; investigation of biogeochemical and transport processes driving water quality in the aquatic and subsurface environment.

The primary purpose of the ASRM and SREI Research Grant Programs is to provide funds for new investigators to establish independent research programs. New investigators are those who have completed their training within the past three years and have independent faculty appointments at the commencement of the research. In special cases, ASRM will consider applications for bridge funding (i.e., between grant funding periods) for projects that are of benefit to other members of the Society, or for funding of new, highly innovative research projects by established investigators. Both the ASRM Research Grants, which are funded by the ASRM, and the SREI Research Grants, which are funded by SREI, are reviewed by the ASRM Research Committee. Grants in amounts of $10,000 to $50,000 will be considered for funding by the ASRM Board of Directors on an annual basis. A total of $200,000 is available for 2016. The SREI Board of Directors will fund one grant of up to $40,000. Funds are available for project expenses, technical assistance, patient expenses, research supplies and durable laboratory equipment. Up to ten percent (10%) of funds may be used for indirect costs or institutional overhead in circumstances deemed to be extraordinary by the Research Committee. Research grant funds may be expended over a 2-year time interval. If residual funds remain after 2 years, the principal investigator can apply for a no-cost extension. An individual should indicate which grant(s) he/she is applying for though he/she is eligible to receive only one grant.

The U.S. Department of the Interior, Bureau of Reclamation (Reclamation), is currently requesting pre-proposals for the Desalination and Water Purification Research and Development Program (DWPR) for research and pilot scale projects aimed at increasing usable water supplies in the United States. The Water Desalination Act of 1996 laid the foundation for the DWPR program. This and the current Continuing Resolution are the authorizing legislation for this program. The purpose of the pre-proposal process is to give proposers the opportunity to receive feedback on their proposal ideas such that full proposal submission are better aligned to meet the desired outcomes of the DWPR program.

The MES program supports research on design, planning, and control of operations in manufacturing enterprises. Research is supported that is both grounded in an interesting and relevant application and requires the development of novel analytical and computational methodologies that may be of broader interest. Topics of interest include supply chain optimization and management; production planning and scheduling; monitoring and control of manufacturing processes; and maintenance and repair. Of particular interest are methods that incorporate increasingly rich enterprise process and product information and models, methods that address sustainability, and methods that incorporate characteristic uncertainty and risk.

The MES program supports research on design, planning, and control of operations in manufacturing enterprises. Research is supported that is both grounded in an interesting and relevant application and requires the development of novel analytical and computational methodologies that may be of broader interest. Topics of interest include supply chain optimization and management; production planning and scheduling; monitoring and control of manufacturing processes; and maintenance and repair. Of particular interest are methods that incorporate increasingly rich enterprise process and product information and models, methods that address sustainability, and methods that incorporate characteristic uncertainty and risk.

The National Energy Technology Laboratory (NETL) University Turbine Systems Research (UTSR) program manages a portfolio of gas turbine-focused university projects. The NETL-UTSR program is part of an initiative in support of the Office of Fossil Energy's Advanced Turbines program goals, DOE strategic goals and program mission needs. The funding opportunity announcement (FOA) is required to facilitate the development and demonstration of next-generation turbine technology with the goal of producing reliable, affordable, clean, efficient, and cost-effective energy supplies and to address the need for engineering and scientific solutions for air breathing gas turbines and supercritical carbon dioxide (SCO2) power cycles. The work will address scientific Research and Development (R&D) as well as technical challenges in turbine technology in support of DOE's strategic goals, program mission needs and the achievement of programmatic technical goals.

The second major report of the President's Advanced Manufacturing Partnership (AMP), Accelerating U.S. Advanced Manufacturing, provides high-level recommendations for U.S. advanced manufacturing strategies, with emphasis on three manufacturing technology areas (MTAs): Advanced sensing, controls and platforms for manufacturing; Visualization, information, and digital manufacturing; and Advanced materials manufacturing. Detailed information on the recommendations for each MTA can be found in Annexes 1 through 10 of the AMP's report. Also of note are reports from the European Commission1 and industry2,3, which provide descriptions of advances in manufacturing, including leveraging of emerging information technologies. Consistent with the AMP's report, the evolution of manufacturing technology has arguably been most importantly dependent on the application of increasingly powerful and low-cost computation in manufacturing enterprises. NSF researchers are, and have been, actively engaged in pursuing fundamental advances in design theory and translation; real-time sensing and perception; data capture, representation, and analytics; machine architectures and human interfaces; materials and process modeling; scheduling and control algorithms; fault detection, analysis, and correction; and coordination of decisions across distributed production facilities that have led to the globally-connected, low-cost, flexible and resilient supply chains, computer-integrated factories, and digital design systems of the modern world. There is a general consensus about the increasingly important role of powerful, low-cost computation in manufacturing.

Program supports two main types of research: (i) innovations in general-purpose methodology related to optimization, stochastic modeling, and decision and game theory; and (ii) research grounded in relevant applications that require the development of novel and customized analytical and computational methodologies. Both types of proposals must be motivated by an application area of interest to the program. Application areas of interest include supply chains and logistics; risk management; healthcare; environment; energy production and distribution; mechanism design and incentives; production planning, maintenance, and quality control; and national security

The American Association for Cancer Research is accepting applications for its AACR NextGen Grants for Transformative Cancer Research program. The annual program is designed to stimulate highly innovative research from young investigators. Three-year grants of up to $450,000 will be awarded in support of creative, paradigm-shifting cancer research that might not be funded through conventional channels. The funds are intended to support expenses related to the research project, which may include salary and benefits of the grant recipient, postdoctoral or clinical research fellows, graduate students (including tuition costs), and research assistants; research/laboratory supplies and equipment; travel applicable to the research project; publication charges for manuscripts that pertain directly to the funded project; and other research expenses and indirect costs. Research projects must represent a highly innovative approach to a major contemporary challenge in cancer research. The research, which can be in any area of basic, translational or clinical science, must have the potential to lead to groundbreaking discoveries in the field and transform our understanding of the tumorigenesis process and/or ability to treat, detect, or prevent cancer. To be eligible, applicants must have a doctoral degree in a related field and not currently be a candidate for a further doctoral degree. In addition, at the start of the grant term on July 1, 2018, applicants must hold a tenure-eligible appointment at the level of assistant professor; have held this appointment for no more than three years; and work at an academic, medical, or research institution anywhere in the world. AACR membership is required.

North American leaders are calling on youth to champion bold ideas for green growth. Youth are encouraged to look beyond incremental approaches and propose innovative science, technology and business solutions that address the complex sustainability challenges facing North America. Innovative ideas will: Create better or more effective products, processes, services, technologies, business models, marketing, supply chains and/or partnerships for the benefit of society, the economy and the environment. Contribute to the natural asset base of North American economies, create green jobs and/or economic opportunities for citizens in North America. Make good business sense in terms of profitability and potential for growth.

The U.S. Department of Energy seeks to understand the key technical and other barriers that may prevent long-term access to low-cost water supplies that could be best addressed through challenges and prize competitions. For the purposes of this Request for Information (RFI), challenges and prize competitions are tools and approaches the Federal government and others can use to engage a broad range of stakeholders, including the general public, in developing solutions to difficult problems. Challenges and prize competitions rely on competitive structures to drive innovation among participants and usually offer rewards (financial and/or other) to winners and/or finalists. DOE may use the information provided through this RFI to develop challenges and prize competitions to address key water issues. This RFI is not designed to solicit input on DOE's broader R&D efforts on affordable water. The purpose of this Request for Information (RFI) is to gather feedback from stakeholders prior to DOE potentially issuing a Funding Opportunity Announcement (FOA). This RFI is not a FOA; therefore, DOE is not accepting applications at this time. All responses to this RFI must be provided as an attachment (in Microsoft Word format) to an e-mail message addressed to waterprizerfi@ee.doe.gov. Responses must be received no later than 5:00 pm EDT on May 14, 2018. The full content of the announcement can be found on the EERE Exchange website at https://eere-exchange.energy.gov/

This Funding Opportunity Announcement (FOA) will provide funding to address the highest priority R&D areas within biofuel technologies, bioproducts, and biopower. It includes Areas of Interest (AOIs) from all five BETO programs: Feedstock Supply and Logistics; Advanced Algal Systems; Conversion; Advanced Development and Optimization; and Sustainability and Strategic Analysis. Each AOI supports BETO's objectives to reduce the minimum selling price of drop-in biofuels, lower the cost of biopower, enable high-value products from biomass or waste resources, and improve the quality of feedstock characterization and reliability of biorefinery operations. The full FOA is posted on the EERE Exchange website at https://eere-exchange.energy.gov. To apply to this FOA, Applicants must register with and submit application materials through EERE Exchange, EERE's online application portal. Information on where to submit questions regarding the content of the announcement and where to submit questions regarding submission of applications is found in the full FOA posted on the EERE Exchange website.

This Broad Agency Announcement (BAA) enhances the DPA Title III effort by providing to potential offerors information and procedures necessary to identify domestic industrial base projects, potentially meeting the DPA Title III criteria, by using the white paper and proposal formats. Project Announcements for a specific domestic industrial base shortfall, issued subsequent to this BAA, is the main method to initiate a call for white papers, leading to an evaluation and potential request for full proposals. Project Announcement #1 is included with this initial posting of the BAA. Consistent with the law, the DPA Title III Program has derived three broad Focus Areas for potential projects. The Focus Areas are: Sustainment of Critical Production, Commercialization of Research and Development Investments and Scaling of Emerging Technologies.

This program supports research and extension projects that have robust collaborations to increase the participation of women and underrepresented minorities from rural areas in science, technology, engineering, and mathematics fields that are relevant to USDA priorities identified by the Secretary: (i) Promotion of a safe, sufficient, and nutritious food supply for all Americans and for people around the world; (ii) Sustainable agricultural policies that foster economic viability for small and mid-sized farms and rural businesses, protect natural resources, and promote value-added agriculture; (iii) National leadership in climate change mitigation and adaptation; (iv) Building a modern workplace with a modern workforce; and (v) Support for 21st century rural communities

This program supports research and extension projects that have robust collaborations to increase the participation of women and underrepresented minorities from rural areas in science, technology, engineering, and mathematics fields that are relevant to USDA priorities identified by the Secretary: (i) Promotion of a safe, sufficient, and nutritious food supply for all Americans and for people around the world; (ii) Sustainable agricultural policies that foster economic viability for small and mid-sized farms and rural businesses, protect natural resources, and promote value-added agriculture; (iii) National leadership in climate change mitigation and adaptation; (iv) Building a modern workplace with a modern workforce; and (v) Support for 21st century rural communities