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This Funding Opportunity Announcement (FOA) is associated with the Beau Biden Cancer MoonshotSM Initiative that is intended to accelerate cancer research. The purpose of this FOA is to establish Centers of collaborating investigators with the goal of identifying and advancing research opportunities for translating immunotherapy concepts for children and adolescents with cancer toward clinical applications. Specifically, this FOA targets the following area designated as a scientific priority by the Blue Ribbon Panel (BRP): Recommendation (B) that calls for the establishment of a pediatric immunotherapy translational science network. The network was envisioned by the BRP as focusing on identifying new targets for immunotherapies, developing new pediatric immunotherapy treatment approaches (e.g., cancer vaccines, cellular therapy, combinations of immunotherapy agents, and others), and defining the biological mechanisms by which pediatric tumors evade the immune system. The Pediatric Immunotherapy Discovery and Development Network (PI-DDN) Centers will address and implement these BRP recommendations.

Founded in 1972, the Tourette Association of America (formerly known as the Tourette Syndrome Association) has emerged as the premier national nonprofit organization working to make life better for all people affected by Tourette and tic disorders. The association advances its work by raising public awareness and fostering social acceptance; working to advance scientific understanding, treatment options, and care; educating professionals to better serve the needs of children, adults, and families challenged by Tourette and tic disorders; advocating for public policies and services that promote positive school, work, and social environments; providing help, hope, and a supportive community across the nation; and empowering its community to deal with the complexities of this spectrum of disorders. To that end, grants of up to $150,000 over two years will be awarded for basic and clinical studies on all aspects of Tourette syndrome. To be eligible, investigators are required to have an advanced degree such as a Ph.D., M.D. or equivalent or be allied professionals with advanced degrees such as R.N.s, Drs. of O.T., social workers, and related fields. Investigators from nonprofit and for-profit organizations can apply.

This Funding Opportunity Announcement (FOA) is associated with the Beau Biden Cancer MoonshotSM Initiative that is intended to accelerate cancer research. The purpose of this FOA is to establish Centers of collaborating investigators with the goal of identifying and advancing research opportunities for translating immunotherapy concepts for children and adolescents with cancer toward clinical applications. Specifically, this FOA targets the following area designated as a scientific priority by the Blue Ribbon Panel (BRP): Recommendation (B) that calls for the establishment of a pediatric immunotherapy translational science network. The network was envisioned by the BRP as focusing on identifying new targets for immunotherapies, developing new pediatric immunotherapy treatment approaches (e.g., cancer vaccines, cellular therapy, combinations of immunotherapy agents, and others), and defining the biological mechanisms by which pediatric tumors evade the immune system. The Pediatric Immunotherapy Discovery and Development Network (PI-DDN) Centers will address and implement these BRP recommendations.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NICHD R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation's biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development, which are encouraged to include hands-on research experiences. This FOA encourages applications to develop and conduct short-term research education programs to improve the knowledge and research skills of biomedical and behavioral scientists conducting research in areas relevant to the mission of NICHD, including reproductive, developmental, behavioral, social, and rehabilitative processes that determine the health and well-being of newborns, infants, children, adults, families, and populations.

The Russell Sage Foundation (RSF) has long had the mission to improve social and living conditions in the United States. It pursues this goal by supporting outstanding research in the social sciences that explores how social, economic, and political factors affect the lives of Americans and their children. Support of such research remains the Foundation's core focus. RSF also has a long history of encouraging new scientific advances to strengthen the methods, data, and theoretical core of the social sciences. Two recent intellectual developments have prompted RSF to launch a special research initiative that integrates knowledge from the biological and social sciences. First, there has been a paradigm shift in the life sciences, spurred by the realization that many biological processes, rather than being fixed, immutable mechanisms that consign people to particular life outcomes, are instead fluid, dynamic responses to features of the social and physical environments humans inhabit. Second, this shift led researchers to launch interdisciplinary studies that seek to integrate approaches from the social and biological sciences, recognizing the potential for a deeper understanding of how social inequalities are initiated, maintained, and transmitted from one generation to the next.

The purpose of this FOA is to continue support for the Pediatric HIV/AIDS Cohort Study (PHACS) which addresses the clinical course of perinatally acquired HIV infection in adolescents and young adults and the oral and systemic health consequences of in utero and infant exposure to antiretroviral therapy in cohorts of children in the United States.

The NIEHS and partnering Institutes and Centers are establishing an infrastructure, the Human Health Exposure Analysis Resource (HHEAR) as a continuation of the Children's Health Exposure Analysis Resource (CHEAR). The goal of this consortium is to provide the research community access to laboratory and statistical analyses to add or expand the inclusion of environmental exposures in their research and to make that data publicly available as a means to improve our knowledge of the comprehensive effects of environmental exposures on human health throughout the life course. This FOA solicits the HHEAR Coordinating Center (U24) that will serve as the administrative hub and external access point for HHEAR, managing and tracking the flow of projects, materials, and analyses between HHEAR units and participating investigators. In addition, the coordinating center will support administrative functions such as convening HHEAR Steering and Executive Committee meetings, and organizing education, outreach, and publicity activities.

The Children's Tumor Foundation has issued a Request for Proposals for research related to gene-based therapeutic approaches for the treatment of neurofibromatosis type 1 (NF1). The initiative will support proof of principle in vitro studies focused on the feasibility of genome editing techniques (including but not limited to those based on CRISPR-Cas9) to correct pathogenic mutations in NF1 gene. Funding for each study will be $240,000 total (inclusive of 10 percent indirect costs) over two years.

The Vera and Joseph Dresner Foundation in West Bloomfield, Michigan, is dedicated to transforming lives in profoundly positive ways through grants focused on health, youth and animal welfare. The foundation's MDS Research Fund (MDSRF) seeks to advance the understanding and treatment of Myelodysplastic Syndromes (MDS) and related blood disorders and expands the foundation's investments in support of cutting-edge basic, translational, and clinical MDS research with the potential to establish future standards of care and, ultimately, a cure. The foundation will consider proposals in two categories from individuals at university, college, hospital, or laboratory institutions for support of research in MDS or related disorders:

The purpose of this Funding Opportunity Announcement (FOA) is to support research that will identify changes in immune mechanisms and markers because of Mycobacterium tuberculosis (M.tb) exposure, infection or disease in pediatric populations exposed to or infected with HIV-1.

NOTE: This is a limited submission opportunity. Please contact Research & Innovation at 9-3600 if you are interested in your proposal being considered for Miami's institutional submission for this opportunity. The goal of this funding opportunity is to accelerate the discovery of additional diagnostic and therapeutic pathways for Gastroparesis by addition of basic and translational research studies to NIDDK's Gastroparesis program. In particular, NIDDK invites applications that will apply recent advances and technologies in immunology, inflammation, microbiology, gastrointestinal physiology and neuroscience to study the complex problem of Gastroparesis.