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Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Frassetto L, Morris RC Jr, Sellmeyer DE, Todd K, Sebastian A. Eur J Nutr. 2001 Oct;40(5):200-13. Review. PMID: 11842945

Frassetto LA, Nash E, Morris RC Jr, Sebastian A. Comparative effects of potassium chloride and bicarbonate on thiazide-induced reduction in urinary calcium excretion. Kidney Int. 2000 Aug;58(2):748-52. PMID: 10916098 [PubMed - indexed for MEDLINE]

Developmental toxicity evaluation of berberine in rats and mice. Jahnke GD, Price CJ, Marr MC, Myers CB, George JD. Birth Defects Res B Dev Reprod Toxicol. 2006 Jun;77(3):195-206. PMID: 16634078 DOI: 10.1002/bdrb.20075 BACKGROUND: Berberine, a plant alkaloid, is found in some herbal teas and health-related products. It is a component of goldenseal, an herbal supplement. Berberine chloride dihydrate (BCD) was evaluated for developmental toxicity in rats and mice. METHODS: Berberine chloride dihydrate was administered in the feed to timed-mated Sprague-Dawley (CD) rats (0, 3625, 7250, or 14,500 ppm; on gestational days [GD] 6-20), and Swiss Albino (CD-1) mice (0, 3500, 5250, or 7000 ppm; on GD 6-17). Ingested doses were 0, 282, 531, and 1313 mg/kg/day (rats) and 0, 569, 841, and 1155 mg/kg/day (mice). RESULTS:There were no maternal deaths. The rat maternal lowest observed adverse effect level (LOAEL), based on reduced maternal weight gain, was 7250 ppm. The rat developmental toxicity LOAEL, based on reduced fetal body weight per litter, was 14,500 ppm. In the mouse study, equivocal maternal and developmental toxicity LOAELs were 5250 ppm. Due to scattering of feed in the high dose groups, a gavage study at 1000 mg/kg/day was conducted in both species. CONCLUSIONS: In rats, maternal, but not fetal adverse effects were noted. The maternal toxicity LOAEL remained at 7250 ppm (531 mg/kg/day) based on the feed study and the developmental toxicity NOAEL was raised to 1000 mg/kg/day BCD based on the gavage study. In the mouse, 33% of the treated females died. Surviving animals had increased relative water intake, and average fetal body weight per litter decreased 5-6% with no change in live litter size. The maternal toxicity LOAEL remained at 5250 ppm (841 mg/kg/day) BCD, based on increased water consumption. The developmental toxicity LOAEL was raised to 1000 mg/kg/day BCD based on decreased fetal body weight.

Sweetness fruit mango panna juice are a leading Manufacturer & Exporter of fruit squash such as Mango Panna juice from India. Mango Panna juice is an Indian drink renowned for its heat resistant properties. It is made from green mangoes and it is used as a tasty and healthy beverage to fight against the intense Indian summer heat. Apart from being tasty drink also looks good due to its refreshing light green colour. Green Mango is a rich source of pectin, which gradually diminishes after the formation of the stone. Unripe mango juice is sour in taste because of the presence of oxalic, citric and malic acids. mango panna juice which is prepared using raw mangoes, sugar and an assortment of spices is an effective remedy for heat exhaustion and heat stroke. It also quenches thirst and prevents the excessive loss of sodium chloride and iron during summer due to excessive sweating. This drink is also a good source of vitamin B1 and B2 and contains sufficient quantity of niacin, and since it is prepared from raw mangoes it is an excellent source of vitamin C also. Aam Panna is also considered as a curative for blood disorders because of its high vitamin C content. Mango panna juice Owing to year of experience in this domain, we are engaged in providing best quality of Mango Panna juice. It is processed using green mangoes and it is used as a tasty and healthy beverage. Further, these products are available in market at pocket friendly prices and known for their rich taste. Our products are of premium quality. Some health benefits of panna mango juice: 1.It prevents you from heat stroke and keeps the body cool. 2.Raw mangoes are rich in vitamin c and iron, plus the jaggery also gives an iron boost. 3.The aam panna helps in preventing stomach problems in the summers. panna juice are three indian drinks i often make in the summers are shikanji, mango panna juice and Mango drink. they all are summer

Morris RC, Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A. Differing effects of supplemental KCl and KHCO3: pathophysiological and clinical implications. Semin Nephrol. 1999 Sep;19(5):487-93. Review.