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Berberine reduces the hypoxic-ischemic insult in rat pup brain. Benaissa F, Mohseni-Rad H, Rahimi-Moghaddam P, Mahmoudian M. Acta Physiol Hung. 2009 Jun;96(2):213-20. PMID: 19457765 DOI: 10.1556/APhysiol.96.2009.2.6 Pathologic review of the samples obtained from rats treated with different doses of berberine in comparison with samples from pups treated by normal saline showed that there was a significant reduction of brain injury and edema in the rats treated with berberine. Our study also demonstrates that berberine reduces brain ischemic-hypoxic injury dose-dependently. Therefore, beberine may be considered as useful anti-stroke agent.

Brain injury refers to a condition in which deterioration or destruction of the brain cells occurs. It is estimated that in America almost 2.6 million people suffer from different kinds of brain injury every year.

ScienceDaily (July 1, 2005) - St. Louis, June 28, 2005 -- Expectant mothers at risk of premature birth may want to consider drinking pomegranate juice to help their babies resist brain injuries from low oxygen and reduced blood flow, a new mouse study from Washington University School of Medicine in St.

Loren DJ, Seeram NP, Schulman RN, Holtzman DM. \nMaternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury.\nPediatr Res. 2005 Jun;57(6):858-64. Epub 2005 Mar 17.\nPMID: 1577483

Neuroprotective effects of berberine on stroke models in vitro and in vivo. Zhou XQ, Zeng XN, Kong H, Sun XL. Neurosci Lett. 2008 Dec 5;447(1):31-6. Epub 2008 Sep 30. PMID: 18838103 doi:10.1016/j.neulet.2008.09.064 Findings of this study suggest that berberine protects against ischemic brain injury by decreasing the intracellular ROS level and subsequently inhibiting mitochondrial apoptotic pathway.