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"Cancer diagnosis and management depend upon the extraction of complex information from microscopy images by pathologists, which requires time-consuming expert interpretation prone to human bias. Supervised deep learning approaches have proven powerful, but are inherently limited by the cost and quality of annotations used for training. Therefore, we present Histomorphological Phenotype Learning, a self-supervised methodology requiring no labels and operating via the automatic discovery of discriminatory features in image tiles. Tiles are grouped into morphologically similar clusters which constitute an atlas of histomorphological phenotypes (HP-Atlas), revealing trajectories from benign to malignant tissue via inflammatory and reactive phenotypes. These clusters have distinct features which can be identified using orthogonal methods, linking histologic, molecular and clinical phenotypes. Applied to lung cancer, we show that they align closely with patient survival, with histopathologically recognised tumor types and growth patterns, and with transcriptomic measures of immunophenotype. These properties are maintained in a multi-cancer study."

"ChatGPT can help with reframing thoughts and situations, similar to cognitive behavioural therapy - but "some clients can start to use it as a substitute for therapy", Masterson says. "I've had clients telling me they've already processed on their own, because of what they've read - it's incredibly dangerous." She has had to ask some clients to cease their self-experiments while in treatment with her. "It's about you and me in the room," she says. "You just cannot have that with text - let alone a conglomeration of lots of other people's texts." Self-directed chatbot therapy also risks being counterproductive, shrinking the area of inquiry. "It's quite affirmative; I challenge clients," says Masterson. ChatGPT could actually cement patterns as it draws, over and again, from the same database: "The more you try to refine it, the more refined the message becomes.""

"According to a new report from 404Media, as originally reported in Alexios Mantzarlis' Faked Up newsletter, the Crush AI modifier app receives the vast majority of its traffic from Meta platforms such as Facebook and Instagram. According to Similarweb's data, last month Crush AI received more than a quarter of a million visits to its service - and roughly 90 percent of that traffic was from Meta's platforms. Crush AI makes it quite clear what the purpose of its service is in its advertisements. The company's ads include photos of real-life individuals like Instagram influencer and model Mikayla Demaiter and OnlyFans creator Sophie Rain. The ads boast that users can "upload a photo" and "erase anyone's clothes.""

"When was the last time your chatbot disagreed with you? Probably only when you told it to. Companion AIs-like Replika, Nomi, or Character.ai-are tuned to be supportive, affirming, and endlessly agreeable. That might feel good in the moment. But what happens when people start preferring digital "friends" over real ones-especially when real ones come with friction?"

"The researchers established a complex picture in terms of the impact. Voice-based chatbots initially appeared to help mitigate loneliness compared with text-based chatbots, but this advantage started to slip the more someone used them. After using the chatbot for four weeks, female study participants were slightly less likely to socialise with people than their male counterparts. Participants who interacted with ChatGPT's voice mode in a gender that was not their own for their interactions reported significantly higher levels of loneliness and more emotional dependency on the chatbot at the end of the experiment."

"How is a 14-year-old supposed to understand that such chatbots work a lot like an echo - that the more he spoke and the greater his longings, the deeper the longings of his "girlfriend" became too, and no matter what he said, the more she encouraged him. The more he thought about death, the more often she asked about it. She was, after all, merely the reflection of his own voice, albeit one trained by a vast amount of data. At some point, Sewell must have stopped believing that the real world was outside of this labyrinth."

"An NHS hospital in west London is pioneering the use of Artificial Intelligence (AI) to help check for skin cancer. Chelsea and Westminster Hospital said its AI technology has been approved to give patients the all-clear without having to see a doctor. Once photos are uploaded to the system, the technology analyses and interprets the images, with 99% accuracy in diagnosing benign cases, the hospital said. Thousands of NHS patients have had urgent cancer checks using the AI tool, freeing up consultants to focus on the most serious cases and bringing down waiting lists. The system conducts the checks in minutes, with medical photographers taking photos of suspicious moles and lesions using an iPhone and the DERM app, developed by UK firm Skin Analytics."

"Umi is a digital wellness platform and personalized family wellness coach that integrates AI and a community of experts. By consolidating wellness data into personalized, actionable pathways for every family, Umi helps people build healthy habits and connect through wellness routines that work for everyone. And by leveraging the power of Anthropic's Claude AI model, Umi benefits from the advanced reasoning capabilities to navigate the unique challenges faced by individuals and families."

"Cancer patients in west Norfolk are benefiting from a new surgical robot. The £1m machine called Versius allows surgeons to perform long, complex procedures more comfortably. It has been bought by the Queen Elizabeth Hospital in King's Lynn and is expected to be used to treat 100 patients in its first year. Currently it is used for colorectal surgery, but the plan is to use it for urology and gynaecological procedures as well."