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"Everyone knows these statements aren't literally true, but although we might understand their figurative meaning, they continue to reflect, and influence, how we think. Even biologists, being quite human, too often think metaphorically and assign properties to genes that genes don't have. The metaphor works because our society has a deeply embedded belief in genes as clearly identifiable material things which explain our individual natures, making them inherent from the moment of our conception and thus predictable. If hydrogen and oxygen are the causal atoms of water, genes are the causal atoms of our existence."

By the age of five, one in four children are either overweight or obese. While easy access to high calorie foods and sedentary lifestyles have driven the rise in childhood obesity in recent years, some children seem able to eat what they like and remain thin, while others gain weight very easily. An individual's risk of gaining weight is strongly influenced by their genes, and some children who gain a lot of weight, are known to have faulty genes.

In the flagship article, The ENCODE Project Consortium et al.5 provide a bird's-eye view of the updated encyclopedia, which contains newly added data sets from 6,000 experiments, performed on around 1,300 samples. By integrating these data sets, the consortium has created an online registry of candidate CREs. Most are classified as promoters or enhancers - CREs respectively located at or some distance from the genomic site at which transcription of a gene begins. The consortium tracked the activity of each candidate CRE, along with the proteins that bind to it in many different samples from various tissues. They used chromatin-looping data to link enhancers to genes that they might regulate. This online registry marks a true milestone, turning an overwhelming amount of genomic information into a searchable, filterable and retrievable encyclopedia of DNA elements, which is freely accessible at https://screen.encodeproject.org.

Recent major surveys show that reductions in genomic complexity - including the loss of key genes - have successfully shaped the evolution of life throughout history.

Researchers from The Institute for Integrative Systems Biology have discovered a new gene family of antimicrobial peptides (small proteins) -the Blattellicins- in a German cockroach (Blattella germanica). The study, published in the journal Scientific Reports, may help to understand how these insects can live in unsanitary environments and defend themselves against the fungal and bacterial pathogens they encounter via the beneficial symbiotic organisms that they harbor.