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In the flagship article, The ENCODE Project Consortium et al.5 provide a bird's-eye view of the updated encyclopedia, which contains newly added data sets from 6,000 experiments, performed on around 1,300 samples. By integrating these data sets, the consortium has created an online registry of candidate CREs. Most are classified as promoters or enhancers - CREs respectively located at or some distance from the genomic site at which transcription of a gene begins. The consortium tracked the activity of each candidate CRE, along with the proteins that bind to it in many different samples from various tissues. They used chromatin-looping data to link enhancers to genes that they might regulate. This online registry marks a true milestone, turning an overwhelming amount of genomic information into a searchable, filterable and retrievable encyclopedia of DNA elements, which is freely accessible at https://screen.encodeproject.org.

"We are developing next generation technology to store digital information in DNA molecules. Our vision is to fit the information content of entire data centers in the palm of your hand. We have proven our approach to encoding data in DNA and are in the process of scaling up our platform. CATALOG technology will make it economically attractive to use DNA as a medium for long-term archival of data."

The Forum's perspective on present and future technological and societal changes is captured in their 'Principled Framework for the Fourth Industrial Revolution.' Philbeck explained the four principles that characterize the Fourth Industrial Revolution. * Think systems, not technologies. Individual technologies are interesting, but it is their systemic impact that matters. Emerging technologies challenge our societal values and norms, sometimes for good, but sometimes also in negative ways; the Fourth Industrial Revolution will have civilization-changing impact-on species, on the planet, on geopolitics, and on the global economy. Philbeck suggested that wealth creation and aggregation supported by this phase of technological innovation may challenge societal commitments to accessibility, inclusivity, and fairness and create the need for relentless worker re-education. As Philbeck stated, "The costs for greater productivity are often externalized to stakeholders who are not involved in a particular technology's development." * Empowering, not determining. The Forum urges an approach to the Fourth Industrial Revolution that honors existing social principles. "We need to take a stance toward technology and technological systems that empowers society and acts counter to fatalistic and deterministic views, so that society and its agency is not nullified," said Philbeck. "Technologies are not forces; we have the ability to shape them and decide on how they are applied." * Future by design, and not by default. Seeking a future by design requires active governance. There are many types of governance-by individuals, by governments, by civic society, and by companies. Philbeck argued that failure to pay attention to critical governance questions in consideration of the Fourth Industrial Revolution means societies are likely to allow undemocratic, random, and potentially malicious forces to shape the future of technological systems and th

The systems we use to encode expertise tend to depend on relatively slow processes of collective computation and don't typically work as measures of an individual's actual extra-institutional networks or their ability to respond to novelty. Organizations and metrics tuned to slow and stable periods that favor efficiency and specialization tend to suppress generalists and improvisation.