Cerebral Palsy

Study designed to evaluate the efficacy and tolerability of ilaprazole relative to that of esomeprazole in healing erosive esophagitis and resolving accompanying symptoms of GERD.

Completed study on Motilin, a peptide, whose action is controlled by motilin receptors located in the gut. Action of Motilin at motilin receptors increases the gastric emptying rate (rate of emptying of food and fluid from the stomach). Compounds which stimulate motilin receptors therefore provide a potential approach to the treatment of a range of clinical conditions where delayed gastric emptying may contribute to symptoms, such as enteral feeding ntolerance (post-operative or intensive care patients), gastroparesis, diabetic gastroparesis, and functional dyspepsia. This study is the First Time In Human study for the motilin receptor agonist, GSK962040.

Future planned study with the objective of evaluating the relative merits, safety and effectiveness of the tailored TIF2 procedure in treating GERD patients who have persistent GERD symptoms despite PPI therapy.The secondary objective of the study is to evaluate the effectiveness of the tailored TIF procedure in restoring the antireflux barrier and eliminating gastroesophageal reflux.

Completed study comparing the blood drug levels of two prescribed medications, Immediate-release omeprazole 40 mg powder and delayed-release omeprazole 40 mg capsule to determine which drug is better absorbed in patients with a slow stomach emptying (gastroparesis). Delayed-release omeprazole has a protective coating to prevent the drug omeprazole from being neutralized by stomach acid. Immediate-release omeprazole has sodium bicarbonate (antacid) which neutralizes the stomach acid, eliminating the need for a protective coating. Immediate-release omeprazole suspension may have a more rapid pharmacokinetic profile and greater overall drug absorption in gastroparesis.

Reseach Mission is to advance neuromuscular functional assessment using objective measurements of muscle tone, strength, and gait. Goal: To apply innovative techniques to facilitate improved treatment strategies and research evaluation.Our work includes measurement of neuromuscular and musculoskeletal function and dysfunction, with emphasis on quantification of the interrelationships of muscle tone, strength, and gait related to medical diagnosis such as: *Cerebral Palsy*Parkinson's Disease*Spinal Cord Injury *Primary Progressive Multiple Sclerosis*Normal Pressure Hydrocephalus*Obesity*Normal aging *Stroke*Transverse Myelitis*Traumatic Brain Injury

Reprint from ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, Vol. 70. January 1989 - Spasticity: Quantitative Measurements as a Basis for Assessing Effectiveness of Therapeutic Intervention

News from Johns Hopkins Departments of Neurology and Neurosurgery

The Johns Hopkins School of Medicine's Brain Science Institute (BSi) brings together both basic and clinical neuroscientists from across the Johns Hopkins campuses. The BSi represents one of the largest and most diverse groups in the University. The goals of our research is to foster new programs in basic neuroscience discovery, initiate a translational research program that will develop new treatments for brain-based diseases and encourage collaboration, interdisciplinary teams, and new thinking that will have a global influence on research and treatment of the nervous system.

As a major international publisher of academic and research journals, Oxford Journals publishes and develops titles in partnership with the world's most prestigious learned societies. Our goal is to bring high quality research to the widest possible audience.

The Rare Diseases Clinical Research Network (RDCRN) is made up of 19 distinctive consortia that are working in concert to improve availability of rare disease information, treatment, clinical studies, and general awareness for both patients and the medical community. The RDCRN also aims to provide up-to-date information for patients and to assist in connecting patients with advocacy groups, expert doctors, and clinical research opportunities

The Metropolitan Atlanta Developmental Disabilities Study (MADDS) was the first U.S., population-based epidemiologic study of the prevalence of intellectual disabilities, cerebral palsy, hearing loss, vision impairment, and epilepsy in school-aged children. National Center on Birth Defects and Developmental Disabilities (NCBDDD) staff have written scientific papers using information from MADDS. These papers look at such topics as how common autism spectrum disorders are and what causes hearing loss in children. You can see a list of these papers (starting in 1990) by using the keyword search on the NCBDDD publications Web page. Choose "MADDS (Metropolitan Atlanta Developmental Disabilities Study)" in the keyword box on the search page. You can choose whether you want the list to be sorted by author or by date

Center is dedicated to helping people live to the fullest. Much of our work focuses on protecting people who are especially vulnerable to health risks - babies, children, people with blood disorders, and people with disabilities

The National Birth Defects Prevention Network (NBDPN) is a group of individuals involved in birth defects surveillance, research, and prevention. It was created to establish and maintain a national network of state and population-based programs for birth defects surveillance and research. The Network assesses the impact of birth defects upon children, families, and health care; identifies factors that can be used to develop primary prevention strategies; and assists families and their providers in secondary disabilities prevention.

Mission at the American Medical Association is to promote the art and science of medicine and the betterment of public health

NCBI PubMed.gov Abstract -Cerebral inflammatory response after fetal asphyxia and hyperoxic resuscitation in newborn sheep. Department of Pediatrics, Lund Uiversity, Sweden Publication

Study of effects of prenatal nicotine exposture by the Instatute of Psychiatry, King's College London. Study design provides a model for the impact of prenatal exposure to nicotine at blood levels comparable with those in medium and heavy smokers. There were marked developmental and behavioural deficits induced in the offspring of nicotine-exposed female rats

NCBI PubMed Abstract, Department of Pediatrics, University of Tennessee Study involving piglets to determine whether the generation of superoxide anion occurs primarily during asphyxia or whether reventilation must take place, 2) to investigate the effects of indomethacin pretreatment at a therapeutic dose of 0.2 mg/kg i.v. on superoxide anion generation, and 3) to investigate the effects of oxypurinol, an oxygen free radical scavenger, on superoxide anion production during asphyxia/reventilation

Journal of the American Physical Therapy Association. Physical Therapy (PTJ) engages and inspires an international readership on topics related to physical therapy. As the leading international journal for research in physical therapy and related fields, PTJ publishes innovative and highly relevant content for both clinicians and scientists and uses a variety of interactive approaches to communicate that content, with the expressed purpose of improving patient care

Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia and Other Focal Dystonias

Effect of treatment on the movement disorder will be measured by a myoclonus scale and a dystonia scale as well as by assessment of overall functional status. Response at various dosages will be compared to baseline for all patients.Safety parameters including neurological examination, blood tests and EKG will be monitored throughout the treatment period and during withdrawal of the medication.