Citicoline Brain Injury Treatment (COBRIT) trial of the effects of 90 days of citicoline on functional outcome in patients with complicated mild, moderate and severe traumatic brain injury. Citicoline (also known as CDP-Choline) is a naturally occurring endogenous compound. Citicoline may have neuroprotective effects and may potentiate neuro-recovery which has led to the evaluation of it as treatment for both stroke and TBI in animal models and in human clinical trials.
Ongoing clinical trial sponsored by the University of Texas Southwestern Medical Center to Evaluate the Effects of a Single Dose of Intravenous Premarin for the Treatment of Severe Traumatic Brain Injury
Research/study hypothesis is that topiramate will reduce acute seizures after traumatic brain injury and will help prevent the development of epilepsy after traumatic brain injury.
National Institute of Neurological Disorders and Stroke NINDS study will use high-resolution magnetic resonance imaging (MRI) to look for subtle differences in brain anatomy between patients with focal hand dystonia (also called writer's cramp) and healthy normal volunteers. Patients with hand dystonia have prolonged muscle contractions that cause sustained twisting movements and abnormal postures. These abnormal movements often occur with activities such as writing, typing, playing certain musical instruments such as guitar or piano, or playing golf or darts.
Oxfordjouornals.org - Brain - A review of differences between basal ganglia and cerebellar control of movements as revealed by functional imaging studies.
The Solomon H. Snyder Department of Neuroscience - the Johns Hopkins University - Asst Professor Mary Ann wilson, PhD - Mechanisms of Development, Plasticity and Injury in the Immature Brain
Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats. Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate
the neuropathological out come of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to investigate the long-term functional and protective actions of granulocyte-colony stimulating factor (G-CSF) treatment in an experimental model of cerebral. RESULTS: Granulocyte-colony stimulation promoted somatic growth and prevented brain atrophy and underdevelopment of the heart in infant rats.
Physiological Reviews - Department of Physiology, University of Wisconsin School of Medicine - Ischemic Cell Death in Brain Neurons - defining Cell Death - Major Features of Ischemic Cell Death - Ischemic Cell Death and Hypoxia
Informational clearinghouse for use by those concerned with finding and evaluating methodologies and treatment for brain-injured children. It is based on the belief that the brain along with the body as a whole is an ever-changing, dynamic, active organ striving for adaptation and capable of healing.
First and original facility to specialize in the neurologic applications of hyperbaric oxygenation and the potentially recoverable brain, treating stroke, coma, traumatic brain injury, Cerebral Palsy, anoxic encephalopathy and multiple sclerosis patients.
Private philanthropy with principal interests in brain science, immunology, and arts education. Charles A. Dana, a New York State legislator, industrialist and philanthropist.
The purpose of this research is to develop tools to help people who are paralyzed. These tools are called brain-computer interfaces (BCIs). BCIs would let a person use brain signals to operate technology
Study being conducted to learn about the effects (both good and bad) of a brain stimulating device known as the External Responsive Neurostimulating System. This is an investigational device that was designed to detect seizure activity and give an electrical stimulation to the brain to try to stop it
NINDS sponsored study will examine how the areas in the brain are connected when they are controlling two finger movements at the same time. Study will examine how people use what they see to help guide two different movements. Studying will further examine the connectivity between the homologous motor areas of the two hemispheres, and between prefrontal cortex and parietal cortex, to understand sensorimotor integration processes during competitive and cooperative dual tasks.
The Johns Hopkins School of Medicine's Brain Science Institute (BSi) brings together both basic and clinical neuroscientists from across the Johns Hopkins campuses. The BSi represents one of the largest and most diverse groups in the University. The goals of our research is to foster new programs in basic neuroscience discovery, initiate a translational research program that will develop new treatments for brain-based diseases and encourage collaboration, interdisciplinary teams, and new thinking that will have a global influence on research and treatment of the nervous system.