Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents.
Mach CM, Fugii H, Wakame K, Smith J.
J Soc Integr Oncol. 2008 Summer;6(3):105-9.
PMID: 19087767
Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype.
Ambrosone CB, McCann SE, Freudenheim JL, Marshall JR, Zhang Y, Shields PG.
J Nutr. 2004 May;134(5):1134-8.
PMID: 15113959
Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implications of CRP and lipid peroxides.
Elmesery ME, Algayyar MM, Salem HA, Darweish MM, El-Mowafy AM.
Cell Div. 2009 Apr 2;4(1):6. [Epub ahead of print]
PMID: 19341447
doi:10.1186/1747-1028-4-6
Nutritional intervention with omega-3 Fatty acids in a case of
malignant fibrous histiocytoma of the lungs.
Pardini RS, Wilson D, Schiff S, Bajo SA, Pierce R.
Nutr Cancer. 2005;52(2):121-9.
PMID: 16201843
Opposing effects of n-6 and n-3 polyunsaturated fatty acids on
pancreatic cancer growth.
Funahashi H, Satake M, Hasan S, Sawai H, Newman RA, Reber HA,
Hines OJ, Eibl G.
Pancreas. 2008 May;36(4):353-62.
PMID: 18437081
doi: 10.1097/MPA.0b013e31815ccc44
Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomy.
Kelavkar UP, Hutzley J, Dhir R, Kim P, Allen KG, McHugh K.
Neoplasia. 2006 Feb;8(2):112-24.
PMID: 16611404
ncident invasive breast cancer, geographic location of residence, and reported average time spent outside.
Millen AE, Pettinger M, Freudenheim JL, Langer RD, Rosenberg CA,
Mossavar-Rahmani Y, Duffy CM, Lane DS, McTiernan A, Kuller LH, Lopez AM, Wactawski-Wende J.
Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):495-507. Epub 2009 Feb 3.
PMID: 19190147
doi: 10.1158/1055-9965.EPI-08-0652
In conclusion, region of residence and geographic solar irradiance are not consistently related to risk of breast cancer and may not be sufficient proxy measures for sunlight/vitamin D exposure. The observed association between time spent outside and breast cancer risk support the hypothesis that vitamin D may protect against breast cancer.
The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature.
Köstner K, Denzer N, Müller CS, Klein R, Tilgen W, Reichrath J.
Anticancer Res. 2009 Sep;29(9):3511-36. Review.
PMID: 19667145
CONCLUSION: Significant associations with VDR polymorphisms have been reported in cancer of the breast (Fok1, Bsm1, Taq1, Apa1, poly (A)), prostate (Fok1, Bsm1, Taq1, poly (A)), skin (Fok1, Bsm1, A-1210), colorectum (Fok1, Bsm1), ovary (Fok1, Apa1) and bladder (Fok1), and in renal cell carcinoma (Taq1, Apa1). However, conflicting data have been reported for most malignancies. After careful evaluation of the actual literature, it can be summarized that data indicating an association of VDR polymorphisms and cancer risk are strongest for breast cancer (Bsm1, Fok1), prostate cancer (Fok1) and malignant melanoma (MM) (Fok1). Data indicating an association of VDR polymorphisms and cancer prognosis are strongest for prostate cancer (Fok1), breast cancer (Bsm1, Taq1), MM (Bsm1) and renal cell carcinoma (Taq1).
Review article: vitamin D acquisition and breast cancer risk.
Pérez-López FR, Chedraui P, Haya J.
Reprod Sci. 2009 Jan;16(1):7-19. Review.
PMID: 19144887
DOI: 10.1177/1933719108327595
Conclusions: Although there are controversial results, it seems plausible that sufficient endogenous vitamin D levels may have a protective function on mammary cells, reducing breast cancer risk.
Association between plasma 25-hydroxyvitamin D and breast cancer risk.
Crew KD, Gammon MD, Steck SE, Hershman DL, Cremers S, Dworakowski E, Shane E, Terry MB, Desai M, Teitelbaum SL, Neugut AI, Santella RM.
Cancer Prev Res (Phila Pa). 2009 Jun;2(6):598-604. Epub 2009 May 26.
PMID: 19470790
In summary, these results add to a growing body of evidence that adequate vitamin D stores may prevent breast cancer development. Whereas circulating 25-OHD levels of >32 ng/mL are associated with normal bone mineral metabolism, our data suggest that the optimal level for breast cancer prevention is ≥40 ng/mL. Well-designed clinical trials are urgently needed to determine whether vitamin D supplementation is effective for breast cancer chemoprevention.
Vitamin d and its role in cancer and immunity: a prescription for sunlight.
Mullin GE, Dobs A.
Nutr Clin Pract. 2007 Jun;22(3):305-22. Review.
PMID: 17507731
DOI: 10.1177/0115426507022003305
Dietary vitamin D and cancers of the oral cavity and esophagus.
Lipworth L, Rossi M, McLaughlin JK, Negri E, Talamini R, Levi F, Franceschi S, La Vecchia C.
Ann Oncol. 2009 Sep;20(9):1576-81. Epub 2009 Jun 1.
PMID: 19487490
Conclusion: We observed inverse associations between dietary vitamin D intake and risk of SCCE and, perhaps, oral/pharyngeal cancer, which were most pronounced among heavy current smokers and heavy consumers of alcohol.
Are sunlight deprivation and influenza epidemics associated with the onset of acute leukemia?
Timonen T, Näyhä S, Koskela T, Pukkala E.
Haematologica. 2007 Nov;92(11):1553-6.
PMID: 18024404
doi:10.3324/haematol.10799
Month of diagnosis of 7,423 cases of acute leukemia (AL) in Finland during 1964-2003 were linked with data on influenza and solar radiation. Acute myeloblastic leukemia (AML) showed the highest risk in the dark season. During the light season, the incidence decreased by 58% (95% confidence interval, 16-79%) per 1,000 kJ/m2/d increase of solar radiation. Independent of solar radiation, AML increased by 9% (95% confidence interval, 0-19%) during influenza epidemics. Reoccurring at the same time annually, darkness-related vitamin D deficiency and influenza could cause successive and co-operative mutations leading to AL with a short latency.