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Matti Narkia

Mitochondrially Targeted Effects of Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dime... - 0 views

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    Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.
    Pereira GC, Branco AF, Matos JA, Pereira SL, Parke D, Perkins EL, Serafim TL, Sardão VA, Santos MS, Moreno AJ, Holy J, Oliveira PJ.
    J Pharmacol Exp Ther. 2007 Nov;323(2):636-49. Epub 2007 Aug 17.
    PMID: 17704354
    doi: 10.1124/jpet.107.128017

    The present work shows that berberine is accumulated by mitochondria of a mouse melanoma cell line, leading to mitochondrial fragmentation and dysfunction, accompanied by decreased cellular energy charge. When the effect was compared with the results obtained on isolated mitochondrial fractions, it is observed that regardless of the system used, berberine is toxic for mitochondria. One major limitation of the present study (as in many others) is the lack of knowledge of the real concentration of berberine that reaches mitochondria in intact cells. Although we do not possess data regarding this aspect, it is wise to speculate that mitochondrial berberine concentrations will be much higher than in the bulk cytosol due to electrophoretic accumulation. We believe that the range of berberine concentrations accumulated by mitochondria in intact cells is within the range of concentrations used on isolated mitochondrial fractions in the present study. The present work not only provides insights on the mechanism by which berberine interferes with tumor cell proliferation, demonstrating previously unknown effects on mitochondrial physiology, but also raises a note of caution on the use of berberine as a nontoxic "natural" over-the-counter medication.
Matti Narkia

Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids - Journal... - 0 views

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    Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids.
    Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Smith A, Edwards IJ, D'Agostino R, Zhang H, Wu H, Kang JX, Chen YQ.
    J Clin Invest. 2007 Jul;117(7):1866-75.
    PMID: 17607361

    Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. This study highlights the importance of gene-diet interactions in prostate cancer.
Matti Narkia

Israeli 'cancer shift' over heart disease mortality may be led by greater risk in women... - 0 views

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    Israeli 'cancer shift' over heart disease mortality may be led by greater risk in women with high intake of n-6 fatty acids.
    Shapira N.
    Eur J Cancer Prev. 2007 Oct;16(5):486-94.
    PMID: 17923822
    doi: 10.1097/CEJ.0b013e3280145b6d

    Population studies of Israeli Jews, Arabs, and women support the association of high n-6 polyunsaturated fatty acid intake with increased cancer risk and higher female sensitivity. Research findings suggest that gender and sex hormones may influence n-6 polyunsaturated fatty acid metabolism and carcinogenesis. This appears to be the first time gender has been proposed to modulate national cancer epidemiology, suggesting implications for differential nutritional prevention, warranting further research.
Matti Narkia

Vitamin D and prevention of breast cancer: pooled analysis. - ScienceDirect - The Journ... - 0 views

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    Vitamin D and prevention of breast cancer: pooled analysis.
    Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC.
    J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
    PMID: 17368188

    CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
Matti Narkia

Vitamin D and Its Role in Cancer and Immunity: A Prescription for Sunlight -- Mullin an... - 0 views

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    Vitamin d and its role in cancer and immunity: a prescription for sunlight.
    Mullin GE, Dobs A.
    Nutr Clin Pract. 2007 Jun;22(3):305-22. Review.
    PMID: 17507731
    DOI: 10.1177/0115426507022003305
Matti Narkia

Are sunlight deprivation and influenza epidemics associated with the onset of acute leu... - 0 views

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    Are sunlight deprivation and influenza epidemics associated with the onset of acute leukemia?
    Timonen T, Näyhä S, Koskela T, Pukkala E.
    Haematologica. 2007 Nov;92(11):1553-6.
    PMID: 18024404
    doi:10.3324/haematol.10799

    Month of diagnosis of 7,423 cases of acute leukemia (AL) in Finland during 1964-2003 were linked with data on influenza and solar radiation. Acute myeloblastic leukemia (AML) showed the highest risk in the dark season. During the light season, the incidence decreased by 58% (95% confidence interval, 16-79%) per 1,000 kJ/m2/d increase of solar radiation. Independent of solar radiation, AML increased by 9% (95% confidence interval, 0-19%) during influenza epidemics. Reoccurring at the same time annually, darkness-related vitamin D deficiency and influenza could cause successive and co-operative mutations leading to AL with a short latency.
Matti Narkia

An estimate of cancer mortality rate reductions in Europe and the US with 1,000 IU of o... - 0 views

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    An estimate of cancer mortality rate reductions in Europe and the US with 1,000 IU of oral vitamin D per day.
    Grant WB, Garland CF, Gorham ED.
    Recent Results Cancer Res. 2007;174:225-34. Review.
    PMID: 17302200
Matti Narkia

Vitamin D and calcium supplementation reduces cancer risk: results of a randomized tria... - 0 views

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    Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial.
    Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP.
    Am J Clin Nutr. 2007 Jun;85(6):1586-91. Erratum in: Am J Clin Nutr. 2008 Mar;87(3):794.
    PMID: 17556697

    Conclusions: Improving calcium and vitamin D nutritional status substantially reduces all-cancer risk in postmenopausal women.
Matti Narkia

Not enough vitamin D: Health consequences for Canadians -- Schwalfenberg 53 (5): 841 --... - 0 views

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    Not enough vitamin D: health consequences for Canadians.
    Schwalfenberg G.
    Can Fam Physician. 2007 May;53(5):841-54. Review
    PMID: 17872747

    Conclusion

    Low levels of VTD are considered a major public health problem in Canada, especially during the winter. Those with risk factors should be screened for low 25(OH)D levels and repletion therapy instituted if needed. Researchers have estimated that the oral dose of vitamin D3 to attain and maintain 25(OH)D levels >80 nmol/L is 2200 IU/d if baseline levels are 20 to 40 nmol/L, 1800 IU/d if levels are 40 to 60 nmol/L, and 1160 IU/d if levels are between 60 and 80 nmol/L.64

    We need to ensure that patients have healthy blood levels of 25(OH)D to prevent levels of parathyroid hormone from rising and to maximize absorption of calcium, magnesium, and phosphate. Positive effects on bone are marginal at best unless patients consume at least 800 IU/d of VTD. The emerging and exciting role of the VTD receptor and the actions of VTD in maintaining health in other cell types have become more apparent during the last decade.
Matti Narkia

DCA or dichloroacetate drug used by dying cancer patients as a last resort - 0 views

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    30 April,2007: Terminally ill patients with incurable cancers are increasingly using a compound via Internet trade that is not yet approved, reports Nature.

    The 'drug' in question -- dichloroacetate (DCA) - has been but found shrinking tumours in rats but yet to put on studies to ascertain its safety in human use.
Matti Narkia

Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficie... - 0 views

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    Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.
    Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB.
    Cancer Res. 2007 Jul 15;67(14):6745-52.
    PMID: 17638885
    doi: 10.1158/0008-5472.CAN-06-4447
Matti Narkia

n-3 Fatty acids, cancer and cachexia: a systematic review of the literature - 0 views

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    Our findings suggest that administration of n-3 FA (EPA and DHA) in doses of at least 1.5 g/day for a prolonged period of time to patients with advanced cancer is associated with an improvement in clinical, biological and QoL parameters.

    N-3 fatty acids, cancer and cachexia: a systematic review of the literature.
    Colomer R, Moreno-Nogueira JM, García-Luna PP, García-Peris P, García-de-Lorenzo A, Zarazaga A, Quecedo L, del Llano J, Usán L, Casimiro C.
    Br J Nutr. 2007 May;97(5):823-31. Review.
    PMID: 17408522
    doi:10.1017/S000711450765795X
Matti Narkia

Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer c... - 0 views

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    It was concluded that omega-3 fatty acid could inhibit the proliferation of pancreatic cancer cell line SW1990 cells and promote their apoptosis. The down-regulation of the cyclin E expression by omega-3 fatty acid might be one of the mechanisms for its anti-tumor effect on pancreatic cancer.

    Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells.
    Zhang W, Long Y, Zhang J, Wang C.
    J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):547-50.
    PMID: 18060632
Matti Narkia

How spicy foods can kill cancers - BBC NEWS | Health - 0 views

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    Scientists have discovered the key to the ability of spicy foods to kill cancer cells.
    They found capsaicin, an ingredient of jalapeno peppers, triggers cancer cell death by attacking mitochondria - the cells' energy-generating boiler rooms.
Matti Narkia

CD40L - a multipotent molecule for tumor therapy. - Bentham Science Publishers - Endocr... - 0 views

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    CD40L - a multipotent molecule for tumor therapy.
    Loskog A, Tötterman TH.
    Endocr Metab Immune Disord Drug Targets. 2007 Mar;7(1):23-8. Review.
    PMID: 17346201
Matti Narkia

Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and prefe... - 0 views

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    Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer.
    Cerchietti LC, Navigante AH, Castro MA.
    Nutr Cancer. 2007;59(1):14-20.
    PMID: 17927497
Matti Narkia

The application of probiotics in cancer - Br J Nutr. 2007 Oct (full text) - 0 views

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    The application of probiotics in cancer.
    de Moreno de LeBlanc A, Matar C, Perdigón G.
    Br J Nutr. 2007 Oct;98 Suppl 1:S105-10. Review.
    PMID: 17922945
    doi:10.1017/S0007114507839602
Matti Narkia

Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antio... - 0 views

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    Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults.
    Gill CI, Haldar S, Boyd LA, Bennett R, Whiteford J, Butler M, Pearson JR, Bradbury I, Rowland IR.
    Am J Clin Nutr. 2007 Feb;85(2):504-10.
    PMID: 17284750
Matti Narkia

Watercress latest super food to fight cancer - Telegraph - 0 views

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    Watercress was declared the latest super food yesterday for being packed with a higher than usual amount of nutrients found in vegetables.
    Research has shown that eating a packet of raw watercress a day, or a bowl full, for eight weeks increased the ability of cells to resist damage to their DNA, helping to protect against the cell changes that lead to cancer.
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