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Are all virus particles infectious? - 0 views

www.virology.ws/...all-virus-particles-infectious
shared by Casey Finnerty on 06 Nov 14 - No Cached
  • A high particle-to-pfu ratio is sometimes caused by the presence of noninfectious particles with genomes that harbor lethal mutations or that have been damaged during growth or purification. Another explanation is that although all viruses in a preparation are in fact capable of initiating infection, not all of them succeed because of the complexity of the infectious cycle. Failure at any one step in the cycle prevents completion. A high particle-to-pfu ratio does not indicate that most particles are defective, but that they failed to complete the infection.
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'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA s... - 0 views

www.sciencedirect.com/...S1357272504000949 HIV
shared by Casey Finnerty on 06 Nov 14 - No Cached
  • Casey Finnerty on 06 Nov 14
     
    This review describes nicely HIV replication and the role of the PPTs.
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No Video. No Photos. No Names. Inside New York's Ebola Monitoring Operation. - NYTimes.com - 0 views

www.nytimes.com/...rks-ebola-monitoring-operation ebolavirus
shared by Casey Finnerty on 13 Nov 14 - No Cached
  • Casey Finnerty on 13 Nov 14
     
    This article gives a very good description of the size of the Ebola monitoring effort underway in NYC and around the country.
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Discussion Ebola Research Needs | Video | C-SPAN.org - 2 views

www.c-span.org/video ebolavirus
shared by Casey Finnerty on 24 Nov 14 - No Cached
  • Casey Finnerty on 24 Nov 14
     
    This panel has the best overview of the research needs for Ebola virus that I have seen. It includes the presentation by CJ Peters that I discussed in class.
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Viruses as a Cure - NYTimes.com - 0 views

www.nytimes.com/...viruses-as-a-cure.html microbiome norovirus
shared by Casey Finnerty on 20 Nov 14 - No Cached
  • When they prevented germ-free mice from making a receptor on the surface of their cells, infection with norovirus didn’t lead to an improvement in their guts.That receptor only latches onto one type of molecule. It’s called Type 1 interferon, and it’s produced by cells when they’re invaded by viruses.
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CRISPR mediated resistance to bacteriophages in prokaryotes - 11 views

www.jstor.org/20035854
shared by lseabs on 19 Nov 14 - No Cached
  • lseabs on 01 Dec 14
     
    journal article for 11/21 / 12/1
  • alexridesducati on 01 Dec 14
     
    We may need another link to this paper because the link leads to a page that is telling me I cant view the entire paper, just the abstract.
  • lseabs on 08 Dec 14
     
    There is an option to scroll through the pages of the article (the shaded border with an arrow on it)
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Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion ... - 10 views

www.ncbi.nlm.nih.gov/...PMC154290
shared by becky214 on 18 Nov 14 - No Cached
  • We report that the C-terminal region of the HIV-1 gp41 ectodomain (and gp160 precursor molecule) appears to be partially exposed and vulnerable to an antiviral agent before the receptor-mediated conformational changes that initiate membrane fusion.
    • laceemarie
      laceemarie on 18 Nov 14
       
      How long is this domain "exposed and vulnerable" before the membranes fuse? Would whatever antiviral treatment that targets this have to be able to hang around, so to speak, for a while in between HIV-host interactions, without being degraded or absorbed or moved to another place in or out of the body?
  • and those that can eliminate infected cells, thereby reducing persistent and latent reservoirs of the virus.
    • apopp10
      apopp10 on 30 Nov 14
       
      It would be interesting to see if there will be a drug that can eventually do this that will be low-cost and is manageable in dosage. The problem is how much the virus mutates to evade these drugs and the host immune system. Combination therapy with the RT inhibitor, protease inhibitor, the experimental design listed her and this drug may be effective at treating HIV in the future.
  • These studies do not determine whether 5-Helix interacts with the native conformation of Env or, rather, some misfolded conformation of gp41 and gp160 on the cell surface.
    • Sean Hogan
      Sean Hogan on 02 Dec 14
       
      What would cause the misfolding of Env? Wouldn't it be advantageous to interact with both in order to prevent HIV infection?
  • ...2 more annotations...
  • Moreover, we demonstrate that this binding is sufficient to concentrate a recombinant toxin to selectively kill HIV-1-infected cells. Our results suggest that the gp41 C-peptide region is a viable target for development of antiviral therapeutics, neutralizing antibodies, and cytotoxic agents directed against infected cells.
    • becky214
      becky214 on 06 Dec 14
       
      How could this help develop antibodies when it is a a toxin that will kill HIV-1-infected cells? 
  • Such a molecule, administered together with agents that induce the expression of dormant integrated provirus (e.g., cytokines or activators of protein kinase C), might help to reduce or possibly eliminate latent reservoirs of HIV-1
    • becky214
      becky214 on 06 Dec 14
       
      I think this is really interesting that it can possibly eliminate HIV that is latent. I have not heard of any anti-viral agents that target latent cells, and this sounds like it could be revolutionary in research on HIV-1.
  • alexridesducati on 18 Nov 14
     
    Focus paper for wednesday
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The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation - 2 views

www.diigo.com/...fbd43783d2e54e9350c549f5f64a1f
shared by ameliaobert on 14 Nov 14 - No Cached
  • The most significant residue, position 97 in the floor of the peptide binding groove of HLA-B, is associated with the extremes of viral load, depending on the expressed amino acid. This residue has been shown to have important conformational properties that affect epitope-contacting residues within the binding groove (26, 30) and has also been implicated in HLA protein folding and cell-surface expression
    • ameliaobert
      ameliaobert on 14 Nov 14
       
      Most Interesting: That one specific residue can produce high results for a virus for comformational changes pertaining to the epitope binding groove. Most Confusing: If for HLA-B this residue position is important, than in HLA-A and HLA-C what residue would be important for the specific binding grove and conformational epitopes? Would 97 be most important or would if not what would be ther reaonsing behind different residues for different HLA?
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The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation - 11 views

www.ncbi.nlm.nih.gov/...PMC3235490
shared by apopp10 on 14 Nov 14 - No Cached
  • Yet a small number of people demonstrate sustained ability to control HIV replication without therapy. Such individuals, referred to as HIV controllers, typically maintain stable CD4+ cell counts, do not develop clinical disease, and are less likely to transmit HIV to others (2).
    • laceemarie
      laceemarie on 14 Nov 14
       
      This is really cool! I have not heard of this until now. Have these people been studied to find out why this occurs? Is it because of the genetics of the person or a certain mutation in the virus? And the key words here are "less likely." That's a pretty broad statement - "less likely" meaning how likely?
    • slgoogin8981
      slgoogin8981 on 24 Nov 14
       
      It is interesting to see that there are 3 allelic variants that correlate with disease prognosis, but how does this information benefit society? We can't change peoples genetic so to alter their prognosis. Is this just a benefit to know what medications would be most beneficial with the least amount of side effects?
  • Abstract
    • Sean Hogan
      Sean Hogan on 02 Dec 14
       
      Presentation Paper 11/14
  • ...2 more annotations...
  • Although variation in the entire HLA protein is involved in the differential response to HIV across HLA allotypes, the major genetic effects are condensed to the positions highlighted in this study, indicating a structural basis for the HLA association with disease progression that is probably mediated by the conformation of the peptide within the class I binding groove.
    • becky214
      becky214 on 06 Dec 14
       
      If variation in the HLA protein results in different responses to HIV, does it also cause different responses to antiviral HIV drugs?
    • apopp10
      apopp10 on 08 Dec 14
       
      So it's only the amino acid position that accounts for the SNP and HLA association signals? It does not matter what amino acid you place there? Individual amino acid chemistry will have no affect on it?
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