This paper describes the development of the DENV mouse-adapted strain DS10, which can reproduce severe Dengue Fever in the mouse strain AG129. AG129 mice are doubly deficient in the receptors for alpha/beta interferon and gamma interferon.
This page has links to all the HHMI Holiday Lectures on infectious disease topics.Currently these include: "2000 and Beyond: Confronting the Microbe Menace", "AIDS: Evolution of an Epidemic", and "Viral Outbreak: The Science of Emerging Disease".