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Supplemental Article to Lesch et al. (2011); Journal club 1: This article provides interesting support to the effectiveness of lentivirus vectors for gene therapy treatment. Not only is HIV or lentivirus efficient at transduction to rapidly dividing cells, it is also capable of transduction to nondividing cells; making it an exciting vector for gene therapy treatment. The range of diseases that could be treatable with a gene therapy vector that can target other cell types than hematopoietic cells could transform the science of gene therapy.

Focus Article; Journal club 1:This is an article that details a novel technique for production of HIV (lentiviral) vectors for use as tools of gene therapy. The fascinating approach that was developed by the authors uses baculovirus as a vector to infect human embryonic kidney cells in culture with the genes necessary to produce a lentiviral vector with therapeutic capabilities.

Review Article; Journal club 1: This is a basic review article about HIV virus vectors and their potential uses in clinical science.

Supplemental Article to Lesch et al. (2011): This article talks about one of the disorders that is treatable by gene therapy: a relatively rare x-linked chromosomal abnormality that causes immunodeficiency as a result of hematopoietic cell damage causing inefficient T-cell receptor binding. Lentiviruses appear to be good vectors for the gene therapy treatment of this disorder as a highly regulated therapy is required for a beneficial outcome.

Reference paper #2. Gave me information on malaria and baculoviruses.

Supplementary Article to Lesch et al. (2011); journal club 1: This article helps us understand the dangers of attenuated lentiviruses used for gene therapy and other clinical applications. It also details a method for screening newly synthesized lentiviruses for replication competency.

This paper gave me a better understanding of some aspects of my focal paper that were unclear. How to test for HA, and how baculoviruses may be adjuvants in addition to expression vectors.

in this article we can know about unique novel tymoviridae virus. they are characterising about this new virus. one of the most unique feature about them is they can replicate even in mosquitoes!in consider that no mosquitoes have been reported as vectores of plant viruse,this research is quite suprising thing! but something i want to recommend is ...first At the result, it said cell lysates did not react with antisera to known only a few arboviruses of the genera. And said this virus is an uncommon arbovirus . I think the author should define more specially about the subject. and second, this research said that CuTLV virus may be transferred to male mosquitoes feed on plant juices and can started to replicate in the insect also. Because marifviruses can potentially replicate both in plants and in insects but, I can't figure out how this viruse can move into human,(animal) different kinds of species , can make a disease even by male ! I think the writer should more explain about that route. the last thing is There is many pictures .but some of them ,like figure 4&figure 5, are too massy to be hard recognized or unneeded thing. So I think they need more arrangement about picture.

In my opinion, VHFs are among the scariest of viruses. Also, to the best of my knowledge, the reservoir AND vector for the virus have yet to be found. It just pops out of the jungle every so often, and then disappears back into it, Frightening...