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Supplemental Article to Lesch et al. (2011): This article talks about one of the disorders that is treatable by gene therapy: a relatively rare x-linked chromosomal abnormality that causes immunodeficiency as a result of hematopoietic cell damage causing inefficient T-cell receptor binding. Lentiviruses appear to be good vectors for the gene therapy treatment of this disorder as a highly regulated therapy is required for a beneficial outcome.

Supplemental Article to Lesch et al. (2011); Journal club 1: This article provides interesting support to the effectiveness of lentivirus vectors for gene therapy treatment. Not only is HIV or lentivirus efficient at transduction to rapidly dividing cells, it is also capable of transduction to nondividing cells; making it an exciting vector for gene therapy treatment. The range of diseases that could be treatable with a gene therapy vector that can target other cell types than hematopoietic cells could transform the science of gene therapy.