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Supplemental Article to Lesch et al. (2011); Journal club 1: This article provides interesting support to the effectiveness of lentivirus vectors for gene therapy treatment. Not only is HIV or lentivirus efficient at transduction to rapidly dividing cells, it is also capable of transduction to nondividing cells; making it an exciting vector for gene therapy treatment. The range of diseases that could be treatable with a gene therapy vector that can target other cell types than hematopoietic cells could transform the science of gene therapy.

Supplementary Article to Lesch et al. (2011); journal club 1: This article helps us understand the dangers of attenuated lentiviruses used for gene therapy and other clinical applications. It also details a method for screening newly synthesized lentiviruses for replication competency.

Focus Article; Journal club 1:This is an article that details a novel technique for production of HIV (lentiviral) vectors for use as tools of gene therapy. The fascinating approach that was developed by the authors uses baculovirus as a vector to infect human embryonic kidney cells in culture with the genes necessary to produce a lentiviral vector with therapeutic capabilities.