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Matti Narkia

Vitamin D, nervous system and aging. - Tuohimaa et al. - Psychoneuroendocrinology Volume 34, Supplement 1, December 2009, Pages S278-S286 (full text PDF) - 1 views

www.kaluefflab.com/...2009Touhimma.pdf

2009 December Psychoneuroendocrinology study review mini-review vitamin_D 25ohd calcidiol premature aging U-curve U-shape U-shaped nutrition Tuohimaa neurodegeneration calcitriol CVD cancer CNS calcipherol chronic diseases risk curve risk_curve

shared by Matti Narkia on 03 Jan 10 - Cached
  • Matti Narkia on 03 Jan 10
     
    Vitamin D, nervous system and aging. P. Tuohimaa, T. Keisala, A. Minasyan, J. Cachat and A. Kalueff. . Psychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286 NEUROACTIVE STEROIDS: EFFECTS AND MECHANISMS OF ACTION doi:10.1016/j.psyneuen.2009.07.003 This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.
  • rachel999 on 23 Apr 20
     
    My doctor advised us to give Vitamin D to both our children, though our son is more than 4 year old. I decided to find out more about it. I surfed the Internet, read the description of the vitamin (here Canadian Pharmacy site https://www.canadapharmacy.com/ helped me a lot). Finally, I decided to give it to my children. But I didn't know, it is good for adults. Thanks for sharing this information, it is very useful for me!
bruce878

Dubai Dental Clinic | Confident Dubai Palm Dental Clinic - 1 views

My teeth gums was badly effected by some disease which leads my teeth gums to swell badly and every day my teeth gum bleeds it become worst situation for me when bad breath issue started. It was ho...

Dubai Dental Clinic Pediatric Dentistry Cosmetic Teeth Gums Whitening Cleaning Tooth Gum Swelling Problem Palm Best in For Doctor German dentist

started by bruce878 on 27 Nov 19 no follow-up yet
bruce878 liked it
Matti Narkia

Self-Help Cancer - Complementary and alternative cancer treatments - 5 views

www.self-helpcancer.org

self-helpcancer.org Self-Help Cancer John Davidson nutrition treatments therapies portal directory vitamin_D selenium zinc quercetin soy ellagic_acid ellagitannins mushrooms mushroom altmed cam chemotherapy herbs angiogenesis antiangiogenic PDT

shared by Matti Narkia on 29 Jan 10 - Cached
  • Matti Narkia on 29 Jan 10
     
    The Author The author of this site is the British writer, John Davidson. Please note that the author is neither a doctor, nor a qualified health practitioner. Every cancer patient should always consult his or her medical practitioner with regard to the use of complementary remedies or treatments, and nothing on this site should be construed in any way as medical or therapeutic advice. It is simply the result of one person's search for solutions. Please read our disclaimer. About This Site Internet searches trawl up vast amounts of information about cancer, from a broad spectrum of viewpoints. The information and internet links on this site are for those seeking to augment the treatment offered by their hospital oncology (cancer) unit. Of course, a great many other internet sites concerning cancer can be found by keying the requisite search words into any of the major search engines. The content of this site was initially prepared, at the request of medical and nursing staff and others, some weeks after I had had an emergency operation for the removal of a colon cancer, and while undergoing chemotherapy in case any cancer cells had gone AWOL. There had been some escape of cancer cells into associated lymph nodes (3 out of 17, including the most distal), but no other tumours had been picked up by a CT scan. When I returned home from hospital in September 2005, with the help of friends, I started doing some research on cancer. I was amazed to discover that despite the billions of pounds/euros/dollars etc. spent on cancer research, and the many advances in understanding the numerous variants of the disease, the standard treatment for my stage of colon cancer is still a drug (fluorouracil, also called 5FU) that has been in use for more than forty years, has uncomfortable side effects, and which only increases the chances of survival after five years by 5 to 10%.
  • kapil1101 on 02 Feb 16
     
    Good Information
Barbara Smith

Effective Chiropractic Solution - 1 views

started by Barbara Smith on 08 Jan 13 no follow-up yet
Edgar Anderson

Promote the Wonders of Good Nutrition - 1 views

Since I am a health advocate, I decided to build our all-healthy-food restaurant somewhere in Australia. Since I am not an expert with formulating the best menu that consist with all healthy ingred...

started by Edgar Anderson on 28 Dec 12 no follow-up yet
Rachel Renner

You Can Stop Snoring Now! - 1 views

I have been looking for the best solution on How to Stop Snoring. In fact I have tried a number of anti-snoring products that all claimed to be effective yet, nothing happened. But when I tried Noi...

started by Rachel Renner on 13 Dec 12 no follow-up yet
Management Health Solutions Inc

Webinar: Focusing on the Big Picture of Your Supply Chain Yields Compelling Financial Returns - 0 views

upcoming.yahoo.com/...fairfield

mhs events

shared by Management Health Solutions Inc on 24 Oct 12 - No Cached
  • Management Health Solutions Inc on 24 Oct 12
     
    Continuous changes in the healthcare reimbursement criteria require executives across the industry to focus on enterprise-wide changes that have a positive effect on supply chain savings. It's a complex problem and it's easy to get distracted on one issue when having the ability to see a clear BIG picture of your entire supply chain is what can lead to the most dramatic results and return on investments. Register for MHS' webinar on November 01 (2:00pm EST) to learn about how their customers experience an average 4:1 ROI with continual savings into the millions and a positive financial impact to their bottom line through inventory reduction, avoidance of obsolete and expired inventory, improved charge capture for each patient, and physician preference card optimization. Click on http://bit.ly/UvD3nq Presenters *Michael Ferris: Co-Founder, MHS with over 30 years of supply chain management experience *Steve Basiliere: Former Director of Supply Chain Services at Saints Medical Center, Lowell, MA *Art Kozyrovicius: Finance and Procurement Systems Support at New York-Presbyterian Hospital, New York, NY WHY ATTEND? Join a unique discussion with healthcare supply chain thought leaders and understand how to drive significant and sustainable supply chain operational improvements. Get a jump on making an immediate and positive impact on your bottom line as you head into 2013. Register by clicking on http://bit.ly/UvD3nq Note: Event will be online, through WebEx Please Register at http://bit.ly/UvD3nq
Edgar Anderson

Losing Weight Through Professional Help - 1 views

It is not easy being an obese because you always become the subject of ridicule. It is for this reason that I really exerted enough efforts going to the gym in order to lose weight. Yet, I did not ...

started by Edgar Anderson on 25 Sep 12 no follow-up yet
Justin Stone

Effective Stretch Mark Remedy - 4 views

I gave birth six months ago. What bothers me are these stretch marks that are found in my belly. I could not wear my swim wear attire whenever my family would decide to stay at the beach to swim. I...

stretch mark cream skin care

started by Justin Stone on 28 Feb 12 no follow-up yet
Meredith Blige

Proven Very Effective Anti-Snoring Products - 1 views

My husband kept asking me the question "how can I stop snoring" because I always told him that I cannot get enough sleep due to his loud snoring. He was worried that I might get sick, so we searche...

how can I stop snoring

started by Meredith Blige on 25 Oct 11 no follow-up yet
Natural Skincare

Natural Skin Care Products - 1 views

I always want my skin to look fair and natural. I have been using many skin care products, yet, I obtain no change. My skin did not even improve. I am looking for a natural skin care product that...

natural skin care

started by Natural Skincare on 14 Sep 11 no follow-up yet
Meredith Blige

How Can I Stop Snoring? - 1 views

Snoring is really getting in the way of my married life. Every time I sleep my wife keeps on complaining about my disturbing snores. So I often have to sleep on the couch. I often ask myself on Ho...

Snoring

started by Meredith Blige on 23 Aug 11 no follow-up yet
seth morris

A Different Kind of Euphoria with a Legal Pot - 1 views

Looking for a legal pot that is totally intense without getting a hangover the next day is hard to find. But with Herbal Highs Online, we have found the right one. As we were browsing through the p...

Kronic

started by seth morris on 12 Jun 11 no follow-up yet
Sonny Cher

Who Says Smoking Pot is Illegal? - 1 views

I have always been addicted to marijuana. It started out with my friends at high school, since then I cannot turn myself away from experiencing high times puffing marajuana. It feels so nice. Howev...

marajuana

started by Sonny Cher on 18 May 11 no follow-up yet
Sonny Cher

Who Says Smoking Pot is Illegal? - 1 views

I have always been addicted to marijuana. It started out with my friends at high school, since then I cannot turn myself away from experiencing high times puffing marajuana. It feels so nice. Howev...

marajuana

started by Sonny Cher on 18 May 11 no follow-up yet
Matti Narkia

New topics in vitamin D research - Google Books - 2 views

books.google.com/books

2006 books.google book New topics vitamin_D research articles reviews Tuohimaa Lou calcidiol active hormone 25ohd nutrition Stolzt

shared by Matti Narkia on 03 Jan 10 - Cached
  • Matti Narkia on 03 Jan 10
     
    Table of Contents Ch. I Is calcidiol an active hormone? 1 Ch. II Vitamin D as a neurosteroid hormone : from neurobiological effects to behavior 29 Ch. III Inhibitors of vitamin D hydroxylases : mechanistic tools and therapeutic aspects 67 Ch. IV Vitamin D analogues as anti-cancer therapies 145 Ch. V Paricalcitol : a vitamin D2 analog with anticancer effects with low calcemic activity 169 Ch. VI Vitamin D use among older adults in U.S. : results form national surveys 1997 to 2002 181 Ch VII Vitamin D deficiency in migrants 199 Vitamin D is a fat-soluble steroid hormone precursor that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. Strictly speaking, it is not a vitamin since human skin can manufacture it, but it is referred to as one for historical reasons. It is often known as calciferol. The major biologic function of vitamin D is to maintain normal blood levels of calcium and phosphorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. It promotes bone mineralisation in concert with a number of other vitamins, minerals and hormones. Without vitamin D, bones can become thin, brittle, soft or misshapen. Vitamin D prevents rickets in children and osteomalacia in adults -- skeletal diseases that result in defects that weaken bones. This book gathers international research on the leading-edge of the scientific front.
Matti Narkia

Retinol-induced Intestinal Tumorigenesis in Min/+ Mice and Importance of Vitamin D Status. - [Anticancer Res. 2009] - PubMed result - 1 views

www.ncbi.nlm.nih.gov/...20032378

2009 November study research in_vivo animal_study mice Retinol-induced Intestinal Tumorigenesis vitamin_A vitamin_D low_levels deficiency females nutrition cancer medline

shared by Matti Narkia on 01 Jan 10 - Cached
  • Matti Narkia on 01 Jan 10
     
    "Retinol-induced Intestinal Tumorigenesis in Min/+ Mice and Importance of Vitamin D Status. Hetland RB, Alexander J, Berg JP, Svendsen C, Paulsen JE. Anticancer Res. 2009 Nov;29(11):4353-60. PMID: 20032378 The effects of life-long dietary exposure, starting in utero, to high retinol, low vitamin D, or high retinol in combination with low vitamin D on intestinal tumorigenesis in Min/+ mice were investigated. In males, high retinol alone significantly increased the number (2.6-fold) and size (1.3-fold) of small intestinal tumours; in females no significant increase in tumour number or size was seen. In both genders, low vitamin D intake alone did not affect intestinal tumorigenesis. In males, intake of the combined high retinol/low vitamin D diet did not further increase the effects caused by high retinol alone. In females, however, the high retinol/low vitamin D-induced increase in tumour number (3.1-fold) and tumour size (1.5-fold) exceeded that of high retinol alone. In conclusion, a high dietary intake of retinol stimulated intestinal tumorigenesis in Min/+ mice. Furthermore, the results indicate a combined effect of high retinol and low vitamin D on tumorigenesis in females"
Matti Narkia

Dr. Joe's E-News - A Diabetes Newsletter: East German Infants Taking Vitamin D - 1 views

enews.endocrinemetabolic.com/...-infants-taking-vitamin-d.html

enews endocrinemetabolic Prendergast blog_article news Cannell East Germany East_Germany East_German infants vitamin_D megadoses nutrition massive doses hypercalcemia toxicity

shared by Matti Narkia on 23 Dec 09 - Cached
  • Matti Narkia on 23 Dec 09
     
    "From 1955 to 1990, all infants in East Germany received 600,000 IU of Vitamin D every three months for a total of 3,600,000 IU at age 18 months. With the 400 IU/day recommendation of the American Pediatric Association in mind, I ran across this amazing paper while surfing Medline for Vitamin D. According to this paper, all infants in the German Democratic Republic (East Germany) received dangerously high doses of Vitamin D every three months in their doctors office. The policy was in place for 35 years. The first 600,000 IU dose was given at three months and then every three months until the child was 18 months of age. This works out to an average of 6,000 IU per day (actually, for several technical reasons it is not equivalent) for 18 months. The authors collected blood before the dose and then 2 weeks after the quarterly dose to obtain 25(OH)D, 1,25(OH)D, and calcium levels on a total of 43 infants. Before the first dose, at 3 months of age, the average infant was extremely deficient (median 25(OH)D of 7 ng/ml). Two weeks after the first dose the average 25(OH)D level was 120 ng/ml, the second dose 170 ng/ml, the third dose, 180 ng/ml, the fourth dose, 144 ng/ml, the fifth dose, 110 ng/ml and after the sixth and final dose, 3.6 million total units, at age 18 months, the children had mean levels of 100 ng/ml. That is, by the 15 and 18 month doses, the children were beginning to effectively handle these massive doses. The highest level recorded in any of the 43 infants was 408 ng/ml at age 9 months, two weeks after the third 600,000 IU dose. Thirty-four percent of the infants had at least one episode of hypercalcemia but only 3 had an elevated serum 1,25(OH)D. The authors reported that all the infants appeared healthy, even the infant with a level of 408 ng/ml, that is, no clinical toxicity was noted in any of these infants."
Matti Narkia

Bread Fortified with Cholecalciferol Increases the Serum 25-Hydroxyvitamin D Concentration in Women as Effectively as a Cholecalciferol Supplement -- Natri et al. 136 (1): 123 -- Journal of Nutrition - 0 views

jn.nutrition.org/...123

2006 January study research clinical_trial rct humans women vitamin_D vitamin_D3 fortified bread fortification bioavailability absorption status 25ohd supplement supplements nutrition comparison Lamberg-Allardt medline

shared by Matti Narkia on 19 Dec 09 - Cached
  • Matti Narkia on 19 Dec 09
     
    Bread fortified with cholecalciferol increases the serum 25-hydroxyvitamin D concentration in women as effectively as a cholecalciferol supplement. Natri AM, Salo P, Vikstedt T, Palssa A, Huttunen M, Kärkkäinen MU, Salovaara H, Piironen V, Jakobsen J, Lamberg-Allardt CJ. J Nutr. 2006 Jan;136(1):123-7. PMID: 16365070 Both fortified breads increased serum 25-hydroxyvitamin D concentration as effectively as the cholecalciferol supplement. Supplementation or fortification did not affect serum intact parathyroid hormone concentration or urinary calcium excretion. In conclusion, fortified bread is a safe and feasible way to improve vitamin D nutrition.
Matti Narkia

Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-α) in prostate cancer cells - ScienceDirect - Life Sciences - 0 views

www.sciencedirect.com/science

2005 June study research in_vitro vitamin_D vitamin_D-induced up-regulation upregulation TNF-alpha TNF prostate cancer cells prostate_cancer PCa nutrition Tuohimaa apoptosis medline

shared by Matti Narkia on 16 Dec 09 - Cached
  • Matti Narkia on 16 Dec 09
     
    Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells. Golovko O, Nazarova N, Tuohimaa P. Life Sci. 2005 Jun 17;77(5):562-77. Epub 2005 Feb 25. PMID: 15904673 doi:10.1016/j.lfs.2004.10.072 Combined addition of human recombinant TNF-alpha with calcitriol or CB1093 cause enhanced effect in induction of apoptosis. We conclude that under physiological conditions vitamin D activates only the transcription of TNF-alpha gene, for TNF-alpha protein synthesis additional cofactors are required. Therefore a cooperation of vitamin D and TNF-alpha may play an important role in the control of cell growth in prostate cancer.
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