Skip to main content

Home/ Vitamin D/ Group items tagged U-shaped

Rss Feed Group items tagged

Matti Narkia

Vitamin D, nervous system and aging. - Tuohimaa et al. - Psychoneuroendocrinology Volum... - 0 views

  •  
    Vitamin D, nervous system and aging.
    P. Tuohimaa, T. Keisala, A. Minasyan, J. Cachat and A. Kalueff. .
    Psychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286
    NEUROACTIVE STEROIDS: EFFECTS AND MECHANISMS OF ACTION
    doi:10.1016/j.psyneuen.2009.07.003

    This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.
Matti Narkia

Lack of Association between Serum Levels of 25-Hydroxyvitamin D and the Subsequent Risk... - 0 views

  •  
    Lack of association between serum levels of 25-hydroxyvitamin D and the subsequent risk of prostate cancer in Finnish men.
    Faupel-Badger JM, Diaw L, Albanes D, Virtamo J, Woodson K, Tangrea JA.
    Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2784-6.
    PMID: 18086789
    doi: 10.1158/1055-9965.EPI-07-0672
Matti Narkia

Vitamin D, nervous system and aging - ScienceDirect - Psychoneuroendocrinology - 0 views

  •  
    Vitamin D, nervous system and aging.
    Tuohimaa P, Keisala T, Minasyan A, Cachat J, Kalueff A.
    Psychoneuroendocrinology. 2009 Aug 4. [Epub ahead of print]
    PMID: 19660871
Matti Narkia

Both high and low levels of blood vitamin D are associated with a higher prostate cance... - 0 views

  •  
    Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries.
    Tuohimaa P, Tenkanen L, Ahonen M, Lumme S, Jellum E, Hallmans G, Stattin P, Harvei S, Hakulinen T, Luostarinen T, Dillner J, Lehtinen M, Hakama M.
    Int J Cancer. 2004 Jan 1;108(1):104-8.
    PMID: 14618623
    DOI: 10.1002/ijc.11375
Matti Narkia

Enzyme kinetics hypothesis to explain the U-shaped risk curve for prostate cancer vs. 2... - 0 views

  •  
    Enzyme kinetics hypothesis to explain the U-shaped risk curve for prostate cancer vs. 25-hydroxyvitamin D in nordic countries.
    Vieth R.
    Int J Cancer. 2004 Sep 1;111(3):468; author reply 469.
    PMID: 15221979
    DOI: 10.1002/ijc.20218
1 - 5 of 5
Showing 20 items per page