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but gene therapy may be coming to the rescue. Gene therapy’s success in treating  blindness disorders –many are in late stage trials—gave hope to a field deterred by early missteps. And now gene therapy researchers are expanding their gaze to focus on all manner of sensory diseases.

notable success in using gene therapy techniques to treat a sensory disorder came last year when otolaryngolotist

In olfactory dysfunction, there are few curative therapies,

Although previous work had indirectly suggested that changing mitochondrial function affected lifespan, “this is the first clear demonstration [that it] extends mouse lifespan,” Miller added.

well known that mitochondria are linked to health. Some evidence suggests that inhibiting mitochondrial function can be harmful—as in the case of diabetes or obesity—but earlier data from nematodes and fruit flies also suggest a link to lifespan increase. The latest findings are a step toward untangling one of the current debates in the field—whether inhibiting mitochondrial function is detrimental or beneficial,

The average lifespan of BXD mice range from 1 year to almost 2.5 years. The researchers were able to link 3 genes to longevity variability, including mitochondrial ribosomal protein S5 (Mrps5), which encodes a protein integral to mitochondrial protein synthesis. They found that BXD strains with 50 percent less Mrps5 expression lived about 250 days longer than BXD mice with more robust Mrps5 expression.

For language lovers, the facts are grim: Anglophones simply aren’t learning them any more. In Britain, despite four decades in the European Union, the number of A-levels taken in French and German has fallen by half in the past 20 years, while what was a growing trend of Spanish-learning has stalled. In America, the numbers are equally sorry.

compelling reasons remain for learning other languages.

First of all, learning any foreign language helps you understand all language better—many Anglophones first encounter the words “past participle” not in an English class, but in French. Second, there is the cultural broadening. Literature is always best read in the original. Poetry and lyrics suffer particularly badly in translation. And learning another tongue helps the student grasp another way of thinking.

Writing about science poses a fundamental problem right at the outset: You have to lie.

because math is the language of science, scientists who want to translate their work into popular parlance have to use verbal or pictorial metaphors that are necessarily inexact.

Choosing the proper metaphor can make all the difference between distorting science and providing an appropriate context from which nonscientists can appreciate new scientific findings and put them in perspective.

After narrating the history of Latin, Persian, Phoenician and other once-dominant languages, all now either dead or consigned to their native communities, Mr. Ostler argues that English too will sputter out relatively soon. Among the factors dooming it is the lack of any institution to demand its survival—no priestly use, as Latin or Sanskrit had, or government that requires its subjects to keep their linguistic skills up to enjoy full citizenship. As English loses cachet, it will become optional, and ultimately its reign will be one of the shortest in the history of lingua francas.

But regional languages are gaining enough traction in trade to allow their speakers to discard English, particularly if people can transact their cultural and commercial business with the crutch of computer software and machine translation.

The one issue that Mr. Ostler treats insufficiently is what the world might lose after what his subtitle calls "the return of Babel." One needn't be sentimental about English to wonder whether it isn't useful to have one language, rich in literature, that everyone shares in addition to a mother tongue.

“The Hangman’s Daughter” was an e-book hit. Amazon bought the rights to the historical novel by a first-time writer, Oliver Pötzsch, and had it translated from German. It has now sold 250,000 digital copies.

For more than 40 years, Eduardo Galeano’s “The Open Veins of Latin America” has been the canonical anti-colonialist, anti-capitalist and anti-American text in that region

now Mr. Galeano, a 73-year-old Uruguayan writer, has disavowed the book, saying that he was not qualified to tackle the subject and that it was badly written. Predictably, his remarks have set off a vigorous regional debate, with the right doing some “we told you so” gloating, and the left clinging to a dogged defensiveness.

 ‘Open Veins’ tried to be a book of political economy, but I didn’t yet have the necessary training or preparation,” Mr. Galeano said last month while answering questions at a book fair in Brazil, where he was being honored on the 43rd anniversary of the book’s publication. He added: “I wouldn’t be capable of reading this book again; I’d keel over. For me, this prose of the traditional left is extremely leaden, and my physique can’t tolerate it

the smart machines of the future won’t be humanlike geniuses like HAL 9000 in the movie “2001: A Space Odyssey.” They will be more modest machines that will drive your car, translate foreign languages, organize your photos, recommend entertainment options and maybe diagnose your illnesses. “Everything that we formerly electrified we will now cognitize,” Kelly writes. Even more than today, we’ll lead our lives enmeshed with machines that do some of our thinking tasks for us.

This artificial intelligence breakthrough, he argues, is being driven by cheap parallel computation technologies, big data collection and better algorithms. The upshot is clear, “The business plans of the next 10,000 start-ups are easy to forecast: Take X and add A.I.”

Two big implications flow from this. The first is sociological. If knowledge is power, we’re about to see an even greater concentration of power.

Listening is more efficient than reading: When we read, we absorb print with our eyes and translate it into “meaning,” a cumbersome process that requires us first to see the words, then to make sense of them, and finally to employ our imaginations to conjure up events and sounds and characters that aren’t there. Reception by aural means is more direct: All you have to do is listen. Not only that, you can multitask, driving to work or walking the dog.

you can impulse-buy Hermione Lee’s biography of Penelope Fitzgerald while you’re shivering at a bus stop and have it show up on your Kindle reader almost instantly. But there is something about the act of listening that invigorates the mind.

The aural/oral revolution won’t mean the end of the book any more than the e-book did.

In the end, though, Litman concluded, the findings were complicated: these factors could largely tell a dog from a general success, but they couldn’t predict the true runaway sensations.

few things continued to stand out: story and social influence. The most important figure in determining ultimate creative success, Simonton found, was the writer. “We can learn a great deal about what makes a successful film just by focusing on the quality of the screenplay,” he declared. Still, as he’d found earlier, quality did not always translate to quantity

And the thing that could potentially be even more, or at least equally, predictive wasn’t easy to quantify: so-called information cascades (basically, a snowball effect) that result from word-of-mouth dynamics.

Luca Maria Aiello and a few pals from the University of Turin in Italy began studying a social network called aNobii.com in which people exchange information and opinions about the books they love. Each person has a site that anybody can visit. Users can then choose to set up social links with others

To map out the structure of the network, Aiello and co-created an automated crawler that starts by visiting one person’s profile on the network and then all of the people that connect to this node in turn. It then visits each of the people that link to these nodes and so on. In this way, the bot builds up a map of the network

people began to respond to the crawler’s visits. That gave the team an idea. “The unexpected reactions the bot caused by its visits motivated us to set up a social experiment in two parts to answer the question: can an individual with no trust gain popularity and influence?”

Writers hover between a decent poverty and an indecent one; they are expected to render the fruits of their labors for little and even for nothing, and all the miracles of electronic dissemination somehow do not suffice for compensation, either of the fiscal or the spiritual kind.

Journalistic institutions slowly transform themselves into silent sweatshops in which words cannot wait for thoughts, and first responses are promoted into best responses, and patience is a professional liability.

the discussion of culture is being steadily absorbed into the discussion of business. There are “metrics” for phenomena that cannot be metrically measured. Numerical values are assigned to things that cannot be captured by numbers. Economic concepts go rampaging through noneconomic realms:

In 1975, in “The Cook and the Cannibal,” Mr. Glucksmann subjected Marxism to a scalding critique. Two years later, he broadened his attack in his most influential work, “The Master Thinkers,” which drew a direct line from the philosophies of Marx, Hegel, Fichte and Nietzsche to the enormities of Nazism and Soviet Communism. It was they, he wrote in his conclusion, who “erected the mental apparatus which is indispensable for launching the grand final solutions of the 20th century.”

An instant best seller, the book put him in the company of several like-minded former radicals, notably Bernard-Henri Lévy and Pascal Bruckner. Known as the nouveaux philosophes, a term coined by Mr. Lévy, they became some of France’s most prominent public intellectuals, somewhat analogous to the neoconservatives in the United States, but with a lingering leftist orientation.

Their apostasy sent shock waves through French intellectual life, and onward to Moscow, which depended on the cachet afforded by Jean-Paul Sartre and other leftist philosophers

the Islamic State in Iraq and al-Sham, or ISIS; the Islamic State in Iraq and the Levant, or ISIL; and, more recently, the Islamic State, or IS. French officials recently declared that that country would stop using any of those names and instead refer to the group as “Daesh.”

how we talk about this group is central to defeating them.

Laurent Fabius said, “This is a terrorist group and not a state. . . the term Islamic State blurs the lines between Islam, Muslims, and Islamists.” President Obama made similar remarks saying, “ISIL is not Islamic . . . and [is] certainly not a state.”

More 5inShare Email Print A defendant in the Atlanta Public Schools case turns herself in at the Fulton County Jail on April 2. (David Goldman/AP) Earlier this week at The Atlantic, Emily Richmond asked whether high-stakes testing caused the Atlanta schools cheating scandal. The answer, I would argue, is yes... just not in the way you might think. Tests don't cause unethical behavior. But they did cause the Atlanta cheating scandal, and they are doing damage to the teaching profession. The argument that tests do not cause unethical behavior is fairly straightforward, and has been articulated by a number of writers. Jonathan Chait quite correctly points out that unethical behavior occurs in virtually all professions -- and that it occurs particularly when there are clear incentives to succeed. Incentivizing any field increases the impetus to cheat. Suppose journalism worked the way teaching traditionally had. You get hired at a newspaper, and your advancement and pay are dictated almost entirely by your years on the job, with almost no chance of either becoming a star or of getting fired for incompetence. Then imagine journalists changed that and instituted the current system, where you can get really successful if your bosses like you or be fired if they don't. You could look around and see scandal after scandal -- phone hacking! Jayson Blair! NBC's exploding truck! Janet Cooke! Stephen Glass! -- that could plausibly be attributed to this frightening new world in which journalists had an incentive to cheat in order to get ahead. It holds true of any field. If Major League Baseball instituted tenure, and maybe used tee-ball rules where you can't keep score and everybody gets a chance to hit, it could stamp out steroid use. Students have been cheating on tests forever -- massive, systematic cheating, you could say. Why? Because they have an incentive to do well. Give teachers and administrators an incentive for their students to do well, and more of them will cheat. For Chait, then, teaching has just been made more like journalism or baseball; it has gone from an incentiveless occupation to one with incentives.

Chait refers to violations of journalistic ethics -- like the phone-hacking scandal -- and suggests they are analogous to Major-League steroid use, and that both are similar to teachers (or students) cheating on tests. But is phone hacking "cheating"

Phone hacking was, then, not an example of cheating. It was a violation of professional ethics. And those ethics are not arbitrarily imposed, but are intrinsic to the practice of journalism as a profession committed to public service and to truth.

The real-life issues now so embedded with the sports world — like debates over racial injustice, brain damage, the ethics of college sports and cheating at the Olympics, plus 100 other things — cannot be parsed to 140 characters.

? Twitter has turned a lot of sports reporting into play-by-play, hot takes and snarky one-liners. With retweets and replies, the echo can be deafening.

The biggest transformation has been the use of social media, and Twitter is the opium of the sports-reporting masses

The phenomenologists’ leading thinker, Edmund Husserl, provided a rallying cry, ‘To the things themselves!’ It meant: don’t waste time on the interpretations that accrue upon things, and especially don’t waste time wondering whether the things are real. Just look at this that’s presenting itself to you, whatever this may be, and describe it as precisely as possible.

You might think you have defined me by some label, but you are wrong, for I am always a work in progress. I create myself constantly through action, and this is so fundamental to my human condition that, for Sartre, it is the human condition, from the moment of first consciousness to the moment when death wipes it out. I am my own freedom: no more, no less.

Sartre wrote like a novelist — not surprisingly, since he was one. In his novels, short stories and plays as well as in his philosophical treatises, he wrote about the physical sensations of the world and the structures and moods of human life. Above all, he wrote about one big subject: what it meant to be free. Freedom, for him, lay at the heart of all human experience, and this set humans apart from all other kinds of object.

Minimal manning—and with it, the replacement of specialized workers with problem-solving generalists—isn’t a particularly nautical concept. Indeed, it will sound familiar to anyone in an organization who’s been asked to “do more with less”—which, these days, seems to be just about everyone.

Ten years from now, the Deloitte consultant Erica Volini projects, 70 to 90 percent of workers will be in so-called hybrid jobs or superjobs—that is, positions combining tasks once performed by people in two or more traditional roles.

If you ask Laszlo Bock, Google’s former culture chief and now the head of the HR start-up Humu, what he looks for in a new hire, he’ll tell you “mental agility.

In 2013, five years after he co-authored a paper showing that Democratic candidates in the United States could get more votes by moving slightly to the right on economic policy1, Andrew Gelman, a statistician at Columbia University in New York City, was chagrined to learn of an error in the data analysis. In trying to replicate the work, an undergraduate student named Yang Yang Hu had discovered that Gelman had got the sign wrong on one of the variables.

Gelman immediately published a three-sentence correction, declaring that everything in the paper's crucial section should be considered wrong until proved otherwise.

Reflecting today on how it happened, Gelman traces his error back to the natural fallibility of the human brain: “The results seemed perfectly reasonable,” he says. “Lots of times with these kinds of coding errors you get results that are just ridiculous. So you know something's got to be wrong and you go back and search until you find the problem. If nothing seems wrong, it's easier to miss it.”

Student debt has more than tripled since 2004, reaching $1.52 trillion in the first quarter of 2018, according to the Federal Reserve — second only to mortgage debt in the U.S. College costs have outpaced the Consumer Price Index more than four-fold since 1985, and tuition assistance today is often harder to come by, particularly at schools without large endowments.

About 44 million graduates hold student debt, and today’s graduates leave school holding promissory notes worth an average of $37,000, raising concerns that the burden is creating a cascade of pressures compelling many to put off traditional life milestones

The storyline, as it has emerged, is that college debt delays buying a house, getting married, having children and saving for retirement, and there is some evidence that this is happening.