At a home in the Romanian city of Iași, Carlson measured cortisol levels in a group of children ranging from two months to three years old. The caregiver-to-child ratio was twenty to one, and most of the children had experienced severe neglect and sensory deprivation. Multiple times a day, Carlson took saliva samples, tracking how cortisol levels fluctuated in response to stressful events. The children, she found, were hormonally off kilter. Under normal conditions, cortisol peaks just before we wake up and then tapers off; in the leagăne infants, it peaked in the afternoon and remained elevated. Those levels, in turn, correlated with faltering performance on numerous cognitive and physical assessments. Then Carlson tried an intervention modelled on the work of Joseph Sparling, a child-development specialist, and the outcomes changed. When half of the orphans received more touching from more caregivers—an increase in hugs, holding, and the making of small adjustments to clothes and hair—their performance markedly improved. They grew bigger, stronger, and more responsive, both cognitively and emotionally, and they reacted better to stress.