Dr. Goodyear

SaT seems to relate to the bioavailable fraction of the hormone and, thus, appears to be an optimal method for studying hirsute women

These results indicate that daily saliva samples can be combined to clarify the interindividual differences in E2 and PG levels in premenopausal women, and that these interindividual differences may be greater than previously imagined.

t has proven to be reliable and, in some cases, even superior to other body fluids

Saliva includes a large number of inorganic and organic compounds, which act as a "mirror of the body's health."

These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use

Saliva can be used as a diagnostic specimen not only to obtain information more inexpensively and efficiently than serum, but also to provide information not readily available from serum testing.

saliva collection has provided the medical and research community with an excellent medium for the monitoring of plasma steroid levels

Salivary measurements of E2 and progesterone can be used as noninvasive methods for assessment of ovarian function. Salivary specimens can be collected at home and brought to the laboratory for analysis, obviating the need for frequent phlebotomy. The sensitivity and precision of the salivary E2 assay make it comparable with assays of serum E2 for assessing changes in hormone levels.

COMPARISON OF BLOOD SPOT, SALIVARY AND SERUM PROGESTERONE ASSAYS IN THE NORMAL MENSTRUAL CYCLE

We conclude that blood spot and saliva Po levels both correlate well with Po levels in serum, but that blood spot Po levels are more reliable.

CONCLUSION: Testosterone in saliva is a useful indicator for monitoring androgenic status in women with RA.

The measurement of the salivary level is a valuable clinical tool for some hormones (e.g. Cortisol, oestriol, progesterone

Thus it was suggested to collect saliva instead of plasma for the evaluation of testicular secretion of testosterone after hCG administration

Detection of an early estriol surge or increased level (≥2.3 ng/ml) may be clinically helpful in identifying women at elevated risk for preterm labor and birth, allowing for evaluation of biologically based interventions in controlled trials.

Evidently salivary progesterone is a very good alternative to plasma as a sample for use in follow-up during pregnancy.

Salivary estrio

Our work confirms the feasibility of collecting samples for salivary steroid assay in field situations