British Journal of Cancer - Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib - 0 views
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Nathan Goodyear on 19 Nov 14Dichloroacetate (DCA) inhibits aerobic glycolysis via inhibition of Pyruvate Dehydrogenase kinase (PDK), which allows for the phosphorylation of Pyruvate Dehydrogenase and the formation of acetylCo-A. This then feeds the krebs cycle. Increased mitochondrial activity increases ROS and resultant apoptosis of cancer cells.