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Nathan Goodyear

IL-2: The First Effective Immunotherapy for Human Cancer | The Journal of Immunology - 0 views

  • IL-2 is a 15.5-kDa cytokine secreted predominately by Ag-simulated CD4+ T cells, but it can also be produced by CD8+ cells, NK cells, and activated dendritic cells
  • The side effects were transient and returned to baseline following treatment
  • A generalized capillary leak syndrome was induced by IL-2 in vivo that resulted in interstitial pulmonary infiltrates and substantial weight gain in patients
  • ...4 more annotations...
  • IL-2 is the predominant factor responsible for the maintenance of CD4+ regulatory T cells
  • Tumors do not express IL-2 receptors and thus the antitumor activity was the result of IL-2 stimulation of immune cell
  • Patients with metastatic melanoma or metastatic renal cell cancer were uniquely responsive to high-dose IL-2 administration, and except for patients with advanced non-Hodgkin’s lymphomas (35) only rare responses were seen in patients with other tumor types
  • The underlying toxicity of IL-2 results from a capillary leak that leads to fluid extravasation into visceral organs that can compromise their function
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    Great review of the history of IL-2 in the treatment of cancer.  IL-2 stimulates the immune system to attack cancer.  Don't reinvent the wheel; use what is already present and available.
Nathan Goodyear

The draft genome and transcriptome of Cannabis sativa | Genome Biology | Full Text - 0 views

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    history of cannabis sativa
Nathan Goodyear

Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study - The Lancet Oncology - 0 views

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    New study casts doubt on survival benefit from bilateral mastectomy in women with BRCA1 or BRCA 2 breast cancer.   Of concern also, only 14% of women had genetic testing done with most occurring at the time of diagnosis.  It is very likely that these women had significant family history that could have been identified if genetic testing was performed earlier.  
Nathan Goodyear

Dr. William Coley: The "Father of Immunotherapya�? - Cancer Monthly - 1 views

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    Not a research article, but some history on Dr. William Coley.
Nathan Goodyear

(99+) Essential Facts on the History of Hyperthermia and their Connections with Electromedicine | Piotr Gas - Academia.edu - 0 views

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    Nice historical review of hyperthermia work.
indiacardiacsurg

Dr Rajiv Parakh India Evaluated Women Exhibit More Advanced Disease - 0 views

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    "It was interesting to see that females were less likely to present with a history of coronary disease," the best vascular surgeon in Medanta hospital Gurgaon said. "That is a finding that is counterintuitive because the vascular disease is in truth a systemic disorder; consequently any patient with PAD has a high probability of concomitant CAD. Email id- dr.rajivparakh@indiacardiacsurgerysite.com Call for Appointment- +91-9370586696
Nathan Goodyear

Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease - 0 views

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    good review of the history of nattokinase and the physiologic effect of nattokinase.
fitspresso

https://www.thefastleanpro.us/ - 0 views

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    Fast Lean Pro™ (official) | weight lose Formula thefastleanpro.us · by Fast Lean Pro Fast Lean Pro Only $49/Bottle Limited Time Offer! Fast Lean Pro Special Deal + Special 51% Discount Save $300 + 180 Days Money Back Guarantee FastLeanPro The #1 Solution To natural metabolism booster helps you lose weight quickly without starving yourself. Fast Lean Pro is a natural powder supplement for weight loss that has recently been developed by Japanese scientists. Regular Price: $99/per bottle Only for: $49/per bottle What Is Fast Lean Pro? Fast Lean Pro is a powdered dietary powdery supplement designed to aid in weight loss. It contains a unique combination of ingredients that are believed to activate the body's "fasting switch" to optimize results. This product focuses not only on weight loss but also on promoting cellular rejuvenation, fasting, and a healthy metabolism. The concept behind Fast Lean Pro is that incorporating fasting into one's lifestyle can lead to positive outcomes irrespective of individual food choices and eating habits. To comprehend the mechanism of the Fast Lean Pro process, it is necessary to delve into its specific details. One of the few weight loss pills on the market that contains Fibersol is Fast Lean Pro. This safe, specialized fiber adds bulk to its weight when combined with water, curbing your appetite before it throws off your meal plan. If you're trying to lose weight or curb your appetite, Fast Lean Pro can help. Supporting substances such as niacin and chromium contribute to this. The body can further benefit from these nutrients, such as through improved metabolic regulation. Fast lean Pro is non-GMO, vegan friendly, and contains no artificial ingredients or stimulants. Fast Lean Pro is a weight loss product that promotes the body's natural self-feeding process. The body naturally removes old, damaged cells through a process known as autophagy to encourage cell regeneration and repair. Recent studies by a group
spineneuro

Best Gamma Knife Neurosurgeon in Fortis Uses Next Generation Gamma Knife Technique - 101 Press Release - 0 views

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    More than 300,000 sufferers have obtained success rate of gamma knife radiosurgery in India. "History of innovation in radiosurgery started in 1987 whilst we installed first unit, which we've got used to treat more than 14,000 sufferers," said best gamma knife neurosurgeon in Fortis. Phone No.: +91-9325887033 Email: dr.sandeepvaishya@neurospinehospital.com
Nathan Goodyear

Thematic review series: The Pathogenesis of Atherosclerosis An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humans - 0 views

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    Part II of the pathogenesis of atherosclerosis.
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