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in title, tags, annotations or urlGlutamine metabolism in cancer therapy - 0 views
Glutamine metabolism in cancer therapy - 0 views
The Time Is Ripe for a Randomized Trial of Metformin in Clinically Localized Prostate Cancer - 0 views
Metformin Use and All-Cause and Prostate Cancer-Specific Mortality Among Men With Diabetes - 0 views
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Study out of Canada finds that Metformin reduces mortality rates for all-cause and due to prostate cancer in those with diabetes. The key point here is glucose. Metformin is going to inhibit gluconeogenesis and this limit hepatic glucose production feeding the cancer. This is just the abstract and several questions come to mind: what was the glucose control like in these patients? What dietary changes if any were these patients following? A better study would be to compare the effects of a ketogenic diet with restriction of glutamine versus the metformin.
Branched Chain Amino Acid Supplementation for Patients with Cirrhosis | Clinical Correlations - 0 views
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low level of BCAAs in patients with cirrhosis is hypothesized to be one of multiple factors responsible for development of hepatic encephalopathy
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supplementation of BCAAs is thought to facilitate ammonia detoxification by supporting synthesis of glutamine, one of the non-branched chain amino acids, in skeletal muscle and in the brain as well as diminishing the influx of AAAs across the blood-brain barrier
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oral BCAA supplementation is more useful in chronic encephalopathic patients than is parenteral BCAA supplementation in patients with acute encephalopathy
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Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect - 0 views
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reducing oxidative stress with powerful antioxidants, is an important strategy for cancer prevention, as it would suppress one of the key early initiating steps where DNA damage and tumor-stroma metabolic-coupling begins. This would prevent cancer cells from acting as metabolic “parasites
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Oxidative stress in cancer-associated fibroblasts triggers autophagy and mitophagy, resulting in compartmentalized cellular catabolism, loss of mitochondrial function, and the onset of aerobic glycolysis, in the tumor stroma. As such, cancer-associated fibroblasts produce high-energy nutrients (such as lactate and ketones) that fuel mitochondrial biogenesis and oxidative metabolism in cancer cells. We have termed this new energy-transfer mechanism the “reverse Warburg effect.
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Then, oxidative stress, in cancer-associated fibroblasts, triggers the activation of two main transcription factors, NFκB and HIF-1α, leading to the onset of inflammation, autophagy, mitophagy and aerobic glycolysis in the tumor microenvironment
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Branched-chain amino acid metabolism in cancer - 0 views
Glutamine Metabolism in Cancer | SpringerLink - 0 views
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