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FMS Dental Hospital

Best Cosmetic Dental Clinic in India - 0 views

FMS DENTAL is one of the top dental clinics in Hyderabad, India and 5th best dental center in the world (GCR Rating), with multi-specialty practice, in-patient facility and 24 hr. emergency dental ...

Best Cosmetic Dental Clinic in India Dentist

started by FMS Dental Hospital on 27 Mar 18 no follow-up yet
Nathan Goodyear

PET/CT Standardized Uptake Values (SUVs) in Clinical Practice and Assessing Response to... - 0 views

www.ncbi.nlm.nih.gov/...PMC3026294

cancer PET scan PET_CT CT PET_CT scan

shared by Nathan Goodyear on 20 Feb 18 - No Cached
  • use of PET in clinical research, clinical trials, and drug discovery
  • use of PET/CT in assessing response to therapy
  • In some cases, such as Hodgkins lymphoma, quantitative PET/CT imaging may not actually be needed, as success can be defined by the complete absence of tracer uptake in the PET image following a course of standardized therapy
  • ...9 more annotations...
  • The utilization of PET/CT to assess response to therapy is increasing in the US related, in part, to the creation and subsequent favorable results of the National Oncologic PET Registry (NOPR)
  • Changes in size as a result of therapy may take many months to develop and any opportunity to make early decisions about therapy success or failure is often unduly delayed or lost altogether
  • measures of changes in metabolic activity via FDG PET/CT can provide an alternate approach to assess response to therapy -- often very early in the course of treatment
  • Current recommendations are that tumor SUVs should be reported
  • The true tracer uptake in a patient is composed of two components: the first being the amount of tracer uptake (e.g. FDG) associated with the disease status (the signal of interest), which can be modified by the biophysiological status of the patient. One of the more important patient parameters is the blood glucose level, which has been shown to inversely-linearly affect SUVs
  • A prospective study by Crippa et al.30 in eight patients showed that as blood glucose levels were increased from 92.4 ±10.2 to 158 ± 13.8 mg/100 ml by glucose loading, the average SUV of 20 liver metastases decreased from 9.4 ± 5.7 to 4.3 ± 8.3
  • chemotherapy can result in impaired renal function, significantly reducing the clearance of plasma FDG through the kidney and thus increasing tumor SUV relative to an initial PET scan
  • The second component of the true tracer uptake is biological variability
  • The biological variability has been estimated in several test-retest studies7,32–35 at approximately 10% for scans repeated within a few days
  • Nathan Goodyear on 20 Feb 18
     
    Good review of the SUVs of a PET/CT scan.
Nathan Goodyear

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeuti... - 0 views

www.ncbi.nlm.nih.gov/...PMC3159114

glutathione

shared by Nathan Goodyear on 24 Jan 18 - No Cached
  • Nathan Goodyear on 24 Jan 18
     
    great review article of the glutathione pathway
Nathan Goodyear

Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities - 0 views

www.ncbi.nlm.nih.gov/...PMC5746038

Nrf2 cancer

shared by Nathan Goodyear on 28 Jun 19 - No Cached
  • Nathan Goodyear on 28 Jun 19
     
    Very interesting read and one to take note of: initially, upregulating Nrf2 was thought to be a good thing i.e. tumor suppressor, but now it appears that upregulation of Nrf2 is critical to cancer cell survival.
Nathan Goodyear

Combining surgery and immunotherapy: turning an immunosuppressive effect into a therape... - 0 views

jitc.biomedcentral.com/...s40425-018-0398-7

surgery cancer immunotherapy immunosuppression metastasis

shared by Nathan Goodyear on 20 Feb 21 - No Cached
Amol kashikar liked it
  • Nathan Goodyear on 20 Feb 21
     
    The post-operative time period is critical to the long-term metastatic risk of cancer because surgery suppresses the immune system in this critical post-operative time period.
Nathan Goodyear

Glutamine and cancer: cell biology, physiology, and clinical opportunities - 0 views

www.ncbi.nlm.nih.gov/...PMC3754270

glutamine cancer

shared by Nathan Goodyear on 26 Jun 20 - No Cached
  • Nathan Goodyear on 26 Jun 20
     
    Great review of the glutamine and cancer metabolism connection.
Nathan Goodyear

Cancer metastases: challenges and opportunities - ScienceDirect - 0 views

www.sciencedirect.com/...S2211383515001094

metastasis cancer mortality morbidity

shared by Nathan Goodyear on 17 Jan 23 - No Cached
  • Nathan Goodyear on 17 Jan 23
     
    Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for about 90% of cancer deaths.
Nathan Goodyear

Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC8123278

cancer Melatonin

shared by Nathan Goodyear on 12 Aug 22 - No Cached
  • Nathan Goodyear on 12 Aug 22
     
    Melatonin has broad anti-cancer properties.
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