Skip to main content

Home/ Dr. Goodyear/ Group items tagged kinase

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
1More

Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phos... - 0 views

cancerres.aacrjournals.org/...5248 phosphodiesterase colorectal cancer chemoresistance PDE phosphodiesterase inhibitors
shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • Nathan Goodyear on 16 Feb 21
     
    PDE inhibition increases cAMP to restore chemosensitivity in this cell study.
1More

Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in... - 0 views

clincancerres.aacrjournals.org/...659.long pharmacokinetics dosing cancer Quercetin
shared by Nathan Goodyear on 27 Aug 20 - No Cached
  • Nathan Goodyear on 27 Aug 20
     
    Great phase 1 pharmacokinetic study on Quercetin dosing.
1More

Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosi... - 0 views

pubmed.ncbi.nlm.nih.gov/15741161 metastasis local recurrence surgery
shared by Nathan Goodyear on 13 Aug 20 - No Cached
  • Nathan Goodyear on 13 Aug 20
     
    Again, surgical upregulation of PI3k stimulates local recurrence via anti-apoptosis and induction of chemoresistance.
1More

The Targeting of Phosphoinositide-3 Kinase Attenuates Pulmonary Metastatic Tumor Growth... - 0 views

www.ncbi.nlm.nih.gov/...PMC1448916 surgery cancer metastasis
shared by Nathan Goodyear on 13 Aug 20 - No Cached
  • Nathan Goodyear on 13 Aug 20
     
    Surgery increases systemic spread of cancer through upregulation of PI3k
1More

High iodine effects on the proliferation, apoptosis, and migration of papillary thyroid... - 0 views

pubmed.ncbi.nlm.nih.gov/31563816 thyroid cancer cancer Iodine
shared by Nathan Goodyear on 06 Aug 21 - No Cached
  • Nathan Goodyear on 06 Aug 21
     
    Iodine inhibits proliferation and promotes apoptosis in BRAF + papillary thyroid cancer
9More

Plant-Based Nutritional Supplementation Attenuates LPS-Induced Low-Grade Systemic Activ... - 0 views

www.ncbi.nlm.nih.gov/...PMC7826722 TLR4 inflammation LPS metabolic endotoxemia plant-based nutrition plant-based diet plant-based
shared by Nathan Goodyear on 03 Sep 21 - No Cached
  • consumption of this particular diet for at least a 2-month period helped to reduce the outcomes of both acute and chronic inflammation induced by LPS.
  • chronic inflammation compromised both glucose and insulin tolerance, which is normally seen in certain chronic metabolic diseases
  • LPS resulted in an increase in neopterin levels, which is a marker for immune system activation
  • ...6 more annotations...
  • diet enriched in fruits and vegetables (and consequently phytochemicals) was able to reverse the process and maintain and even elevate insulin sensitivity and glucose tolerance
  • LPS-mediated effects are related to an increase in TLR4 levels that triggers the activation of nuclear factor-kB (NF-kB), a transcription factor that activates a cascade of inflammatory mediators [41]. These factors control the transcription of inflammatory mediators, such as IL-1β, IL-6, TNF-α, TNF-β, INF-α, INFβ, INF-γ
  • Inflammation can alter insulin action and give rise to diabetes and obesity by blocking insulin receptor downstream events, impairing insulin receptor substrate 1 (IRS-1) activation and phosphatidylinositol 3-kinase-dependent (PI3K) pathways, therefore compromising insulin signaling
  • systemic inflammation (generated by LPS) also increased neopterin levels in the urine and resulted in altered neuronal activity by decreasing dopamine (DA) metabolism
  • an increase in neopterin levels has been recognized a sensitive biomarker for immune system activation
  • Our experiments denoted that these diets were able to diminish inflammatory mediators and oxidative damage
1More

Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway -... - 0 views

www.ncbi.nlm.nih.gov/...PMC7662796 pancreatic cancer CBD P-21 THC KRAS
shared by Nathan Goodyear on 30 Jan 24 - No Cached
  • Nathan Goodyear on 30 Jan 24
     
    THC:CBD target pancreatic cancer which expresses KRAS mutation appx 90% of time.
« First ‹ Previous 81 - 96 of 96
Showing 20▼ items per page