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Nathan Goodyear

The psychoneuroendocrine-immunotherapy of cancer: Historical evolution and clinical res... - 0 views

www.ncbi.nlm.nih.gov/...PMC5426095

cancer melatonin immunotherapy

shared by Nathan Goodyear on 10 May 18 - No Cached
  • It is known that immune system-induced destruction of cancer cells is mainly mediated by T cytotoxic lymphocytes (CD8+) and NK cells (CD16+), respectively, through an antigen-specific and an antigen nonspecific cytotoxicity
  • NK cells are mainly stimulated by IL-2 released by T helper-1 (TH1) lymphocytes (CD4+) while T cytotoxic lymphocytes (CD8+) are namely under a stimulatory control released by IL-12 produced by the dendritic cells
  • On the other hand, the anticancer immunity is inhibited by the activation of the macrophage system through the production of suppressive cytokines, such as IL-6 and T regulatory (T reg) lymphocytes (CD4+CD25+), which counteract the anticancer immunity by producing immunosuppressive cytokines inhibiting the secretion of both IL-2 and IL-12, including TGF-beta and IL-10, or by a direct cell-cell contact
  • Nathan Goodyear on 10 May 18
     
    to be read review of melatonin in cancer treatment.
Nathan Goodyear

Improved leukemia-free survival after postconsolidation immunotherapy with histamine di... - 0 views

www.bloodjournal.org/...88

AML acute myeloid leukemia leukemia IL-2 histamine

shared by Nathan Goodyear on 12 May 18 - No Cached
  • several independent lines of evidence suggest that cytotoxic effector cells such as T cells and natural killer (NK) cells participate in protecting patients with AML against relapse
  • A plethora of mechanisms have been proposed to account for the dysfunctional antileukemic lymphocytes in AML, including the production of T-cell- and NK-cell-inhibitory factors by AML blasts,48 a deficient expression of NK-cell receptors on leukemic cells,49 inhibition of antileukemic lymphocytes by mononuclear phagocytes,4 and an impaired stimulatory interaction between the CD28 antigen expressed by T cells and contact antigens on AML blasts
  • This trial met the primary endpoint and thus showed a significantly improved LFS for patients receiving HDC/IL-2 as compared with the current standard of care
  • ...2 more annotations...
  • T cells and NK cells with antileukemic activity can be recovered from most patients with AML in remission not receiving a transplant,
  • The present study evaluated an approach to immunotherapy in AML in which IL-2 is supplemented with histamine dihydrochloride (HDC) to enhance the function of cytotoxic antileukemic lymphocytes
  • Nathan Goodyear on 12 May 18
     
    IL-2 plus histamine in patients with AML complete remission improves leukemia free survival.
Nathan Goodyear

First results on survival from a large Phase 3 clinical trial of an autologous dendriti... - 0 views

translational-medicine.biomedcentral.com/...s12967-018-1507-6

dendritic cells cancer glioblastoma multiforme glioblastoma brain cancer

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • Nathan Goodyear on 01 Jun 18
     
    Dendritic therapy, I think the use of vaccine is completely inappropriate here, found to extend life in those with methylated MGMT.  This phase III trial is still on going, but this is a very positive future therapy in the immunotherapy attack against cancer.
Nathan Goodyear

Prevention of interleukin-2-induced thrombocytopenia during the immunotherapy of cancer... - 0 views

www.ncbi.nlm.nih.gov/...7624582

cancer IL-2 melatonin platelets immunotherapy

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • Nathan Goodyear on 01 Jun 18
     
    Only abstract available here to general public.  Thrombocytopenia is associated with IL-2 therapy.  Melatonin found to block this effect when used in conjunction with IL-2 therapy.  Alone, melatonin did not increase platelet levels.  The proposed mechanism is an inhibition of macrophage mediated destruction of plateletes.
Nathan Goodyear

A randomized study of immunotherapy with low-dose subcutaneous interleukin-2 plus melat... - 1 views

www.ncbi.nlm.nih.gov/...7900237

IL-2 melatonin immunotherapy immune system cancer lung cancer chemotherapy

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • Nathan Goodyear on 01 Jun 18
     
    Average progression-free time and percentage of patients alive at 1 year was significantly higher in those using IL-2 and melatonin compared to chemotherapy in aggressive NSCLC. Of note, in this study, they used a repeat cycle of IL-2 and MLT as well as a once/week maintenance IL-2 and MLT.
Nathan Goodyear

Cancer immunotherapy with low-dose interleukin-2 subcutaneous administration: potential... - 1 views

www.ncbi.nlm.nih.gov/...8023699

IL-2 melatonin immunotherapy cancer

shared by Nathan Goodyear on 31 May 18 - No Cached
  • Nathan Goodyear on 31 May 18
     
    high dose melatonin and low-dose IL-2 in wide variety of solid tumors found tumor regression in 17 of 82 patiens (21%).  Four of these were complete remission and 13 were Partial.
Nathan Goodyear

Amplification of eosinophilia by melatonin during the immunotherapy of cancer with inte... - 1 views

www.ncbi.nlm.nih.gov/...8346714

cancer melatonin IL-2 IL-5 eosinophils immunotherapy immune system

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • Nathan Goodyear on 01 Jun 18
     
    Melatonin concomitant with IL-2 found to increase eosinophils.  This occured with MLT and IL-2, not with IL-2 only.  The suggested mechanism is through IL-5 production from T helper cells.
Nathan Goodyear

Immunotherapy of C3H/HeJ mammary adenocarcinoma with interleukin-2, mistletoe lectin or... - 0 views

www.sciencedirect.com/...S0959804901001563

immunotherapy IL-2 mistletoe cancer

shared by Nathan Goodyear on 01 Jun 19 - No Cached
  • Nathan Goodyear on 01 Jun 19
     
    Study finds IL-2 reduces cancer proliferation and metastasis; however, mistletoe alone found to stimulate proliferation, though at very low doses i.e. 1 ng/kg, in mouse model.
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