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jiyaroy11

Guidelines in Clinical Research Assessment - 0 views

crbtech.in/...elated-to-clinical-assessments

crb crb tech reviews tech solutions crb tech solutions review

shared by jiyaroy11 on 22 Jan 16 - No Cached
  • jiyaroy11 on 22 Jan 16
     
    What Are the Steps Related to Clinical Assessments? What's incorrect with Cynthia? There are several factors that can cause forgetfulness.
Nathan Goodyear

An Empirical Evaluation of Guidelines on Prostate-specific Antigen Velocity in Prostate... - 0 views

www.ncbi.nlm.nih.gov/...PMC3057983

PSA psa velocity prostate cancer

shared by Nathan Goodyear on 20 Dec 15 - No Cached
  • men with a high PSA velocity (rate of change of PSA level)—greater than 0.35 ng mL−1 y−1—should consider biopsy even if absolute level of PSA is very low.
  • like other authors, we found strong evidence for a univariate association between PSA velocity and positive biopsy
  • we also found that PSA velocity does not add important predictive value to PSA and other standard predictors; in other words, we did not find that the use of a PSA velocity criterion for biopsy would improve clinical decision making
  • Nathan Goodyear on 20 Dec 15
     
    This is the study that many have used to discredit psa velocity, but that is cherry picking the authors conclusions.  The authors did find an association with a positive psa velocity and + prostate biopsy.  Not useless, but useful in the right context.
Nathan Goodyear

Adapted ECHO-7 virus Rigvir immunotherapy (oncolytic virotherapy) prolongs survival in ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4560272

RIGVIR cancer oncolytic therapy immunotherapy cancer immunotherapy

shared by Nathan Goodyear on 16 Oct 18 - No Cached
  • Rigvir is a 2 ml frozen solution
  • ECHO-7 virus strain, Picornaviridae family, Enterovirus genus, Enteric Cytopathic Human Orphan (ECHO) type 7, group IV, positive-sense single-stranded RNA virus
  • a few side effects were reported, for example subfebrile temperature (37.5°C for a couple of days), pain in the tumour area, sleepiness and diarrhoea
  • ...12 more annotations...
  • In this retrospective study, however, there was no record of any untoward side effect from Rigvir treatment or its discontinuation
  • Early observations of tumour regressions after virus infections have been published starting from the late 19th century
  • The present results show that in substage IB, IIA, IIB and IIC melanoma patients, Rigvir administration after surgery significantly (P<0.05) prolongs survival compared with patients who were managed according to current published guidelines
  • no value higher than grade 2 was recorded in Rigvir-treated patients. This is in contrast to most other cancer therapies, where grades 3 and 4 are frequently observed
  • Administration of virus induces the formation of neutralising antibodies that might potentially influence the efficiency of Rigvir
  • In 94 healthy adult participants tested, the titres were found to be low (1 : 20 to 1 : 62) 39,40. When tested in 155 adult cancer patients who had not been treated with Rigvir, neutralising antibodies against ECHO-7 were detected in ∼50% of the patients
  • the presence of ECHO-7 antibodies was shown to increase with age in children and level off to a plateau of around 75% in adults
  • Rigvir is an immunomodulator that affects both the humoral, antibody-mediated, and the cellular immune systems
  • neutralising antibodies do not affect efficacy when local or regional administration is used
  • it reduces the viability of melanoma, as well as pulmonary, gastric, pancreatic, bone, and breast cancer cell cultures
  • It is oncolytic in melanoma and rectum cancer patients
  • shown to improve the 5-year survival in rectum cancer patients
  • Nathan Goodyear on 16 Oct 18
     
    RIGVIR shown to improve survival against standard therapy in stage IB, IIA, IIB, and IIC in malignant melanoma patients in retrospective study. Side effects are minimal. Neutralizing antibodies are an area to watch that likely effects individual outcome beyond that of the type of cancer
Nathan Goodyear

Diagnosis and Management of Waldenström Macroglobulinemia: Mayo Stratificatio... - 0 views

www.ncbi.nlm.nih.gov/...PMC2931618

Waldenstrom lymphoma "waldenstrom's macroglobulinemia" Cancer

shared by Nathan Goodyear on 30 Oct 18 - No Cached
  • Nathan Goodyear on 30 Oct 18
     
    A must read on waldenstrom's macroglobulinemia.
aileenoleary

Get Free Medicare Guide | Heaven Offers - 0 views

newheavenoffers.com/get-free-medicare-guide

medicare guide guidelines advantage eligibility online apply for questions usa

shared by aileenoleary on 02 Sep 18 - No Cached
  • aileenoleary on 02 Sep 18
     
    This guide will help you construct a solid plan for understanding Medicare Navigating the World of Medicare can be tricky. This is why Medicare World's "2018 Guide To Medicare" is a must have for anyone with Medicare. In this guid we will breakdown the complexities of Medicare to help you make informed decisions.
Nathan Goodyear

Comparisons of normal saline and lactated Ringer's resuscitation on hemodynamics, metab... - 0 views

www.ncbi.nlm.nih.gov/...PMC4029282

IV fluids lactated ringers normal saline LR NS

shared by Nathan Goodyear on 03 Jul 18 - No Cached
  • NS contains 154 mM Na+ and Cl-, with an average pH of 5.0 and osmolarity of 308 mOsm/L.
  • LR solution has an average pH of 6.5, is hypo-osmolar (272 mOsm/L), and has similar electrolytes (130 mM Na+, 109 mM Cl-, 28 mM lactate, etc.) to plasma
  • hyperchloremic acidosis
  • ...26 more annotations...
  • LR’s acid base balance is superior to that of NS’s
  • There were no significant differences between LR and NS groups in fibrinogen concentrations or platelet count
  • Total protein dropped
  • no significant differences in Hct (Table  1) or total protein between LR and NS groups
  • Bicarbonate HCO3- levels were decreased by hemorrhage but returned to pre-hemorrhage values by 3 h after LR resuscitation, whereas no return was observed with NS resuscitation
  • Na+ was increased after NS resuscitation
  • No changes in Na+ or K+ were observed
  • K+ did not change initially after NS resuscitation but was elevated at 6 h afterwards
  • Ca++ was similarly decreased
  • Cl- was elevated for 6 h after NS resuscitation, with no changes shown after LR resuscitation
  • PT was similarly prolonged by resuscitation with LR (from 11.2 ± 0.2 sec at baseline to 12.1 ± 0.2 sec at 6 h) and NS
  • Plasma aPTT was also similarly prolonged by resuscitation with LR (from 17.1 ± 0.5 sec baseline to 20.1 ± 1.2 sec at 6 h) or NS
  • NS resuscitation resulted in better oxygen delivery and oxygen delivery-to-oxygen demand ratio as an index of oxygen debt
  • NS had better tissue perfusion and oxygen metabolism than LR
  • LR resuscitation returned BE and bicarbonate to pre-hemorrhage levels within 3 h, but no return of BE or bicarbonate was observed for 6 hr with NS resuscitation
  • current blood bank guidelines state that LR should not be mixed with blood to prevent the risk of clot formation from calcium included in LR
  • LR resuscitation should not be given with blood through the same iv-line and crystalloids should be avoided in patients with blood transfusion
  • PT and aPTT were prolonged for 6 h after hemorrhage and resuscitation, suggesting a hypocoagulable states
  • potential thrombotic risk from LR resuscitation is unlikely.
  • we suspected that the blood pressure after NS resuscitation would be lower than that of LR due to its vasodilator effects
  • NS required a larger resuscitation volume and was associated with poor acid base status and elevated serum potassium in this model
  • NS required 50% more volume and was associated with a higher cardiac output and lower peripheral resistance, as compared to LR resuscitation
  • These differences are possibly due to the vasodilator effects from NS
  • an elevation of K+ was observed at 6 h post NS resuscitation, while no change of K+ was observed after LR resuscitation
  • The mechanism for the increase of K+ from NS is not fully known
  • NS is associated with vasodilator effects and the risks of metabolic acidosis and hyperkalemia
  • Nathan Goodyear on 03 Jul 18
     
    LR vs NS crystalloid.
Nathan Goodyear

Ozone in Medicine: The Low-Dose Ozone Concept-Guidelines and Treatment Strategies: Ozon... - 0 views

www.tandfonline.com/...01919512.2012.717847

ozone

shared by Nathan Goodyear on 31 Jul 18 - No Cached
  • Nathan Goodyear on 31 Jul 18
     
    ozone
Nathan Goodyear

Clinical review: Specific aspects of acute renal failure in cancer patients - 0 views

www.ncbi.nlm.nih.gov/...PMC1550893

cancer renal failure

shared by Nathan Goodyear on 13 Aug 18 - No Cached
  • uric acid crystal formation in the renal tubules secondary to hyperuricaemia
  • calcium phosphate deposition related to hyperphosphataemia
  • usually develops shortly after the initiation of cytotoxic chemotherapy
  • ...18 more annotations...
  • Non-recombinant urate oxidase (Uricozyme®)
  • recombinant urate oxidase (Rasburicase®)
  • urine alkalisation may induce calcium phosphate deposition
  • renal replacement therapy should be started on an emergency basis when hydration fails to produce a prompt metabolic improvement or when ARF develops
  • Up to 50% of patients with newly diagnosed multiple myeloma have renal failure and up to 10% require dialysis
  • renal ultrasonography remains the method of choice for investigating extra-renal obstruction
  • The relief of the obstruction, either by percutaneous nephrostomy or through a ureteral stent, is the cornerstone of treatment
  • TMA may be associated with the cancer itself, with cancer chemotherapy, or with allogeneic BMT
  • thrombotic microangiopathy (TMA)
  • it may be as high as 5%
  • Most of the cases occur in patients with solid tumours, the most common type being adenocarcinoma (stomach, breast and lung)
  • The pathophysiology of the TMA-malignancy association remains controversial, although many studies suggest an insult to the vascular endothelium
  • mitomycin C. Subsequently, TMA has been reported with many anti-cancer agents, including gemcita-bine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α
  • Plasma exchanges have been shown to improve prognosis in the general population of patients with TMA
  • Causative factors should be looked for and antihypertensive treatment given. Lastly, in the absence of guidelines, we believe that plasma exchange should be proposed in patients with severe cancer treatment-associated TMA
  • The most widely used protective measure is saline infusion to induce solute diuresis
  • During methotrexate infusion and elimination, fluids should be given to maintain a high urinary output and urinary alkalisation should be performed to keep the urinary pH above 7.5. Rescue with folinic acid (50 mg four times a day) should be started 24 hours after each high-dose metho-trexate infusion and serum methotrexate concentrations should be measured every day
  • cyclophosphamide and ifosfamide
  • Nathan Goodyear on 13 Aug 18
     
    cancer and renal failure
lina001

Daily Healthy Life Style - - 0 views

healthstime.info

hormones hormone Testosterone cancer men inflammation Disease Obesity Male low

shared by lina001 on 18 Sep 18 - No Cached
lina001 liked it
  • lina001 on 18 Sep 18
     
    Best Health Tips and guideline for men and women....
Nathan Goodyear

Guidelines to the writing of case studies - 0 views

www.ncbi.nlm.nih.gov/...PMC2597880

case study

shared by Nathan Goodyear on 27 Jun 19 - No Cached
  • Nathan Goodyear on 27 Jun 19
     
    Good read on creating a case study.
Nathan Goodyear

Dietary composition in the treatment of polycystic ovary syndrome: a systematic review ... - 0 views

www.ncbi.nlm.nih.gov/...23420000

PCOS polycystic ovarian syndrome diet nutrition

shared by Nathan Goodyear on 26 Apr 17 - No Cached
  • Nathan Goodyear on 26 Apr 17
     
    Weight loss is the best positive effect for women with PCOS.  Higher fat and protein, with a lower carb diet benefited women with PCOS.  A low Glycemic index plan benefited women with PCOS.  
Nathan Goodyear

A guideline to limit indoor airborne transmission of COVID-19 | PNAS - 0 views

www.pnas.org/...e2018995118

social distancing

shared by Nathan Goodyear on 24 Apr 21 - No Cached
  • Nathan Goodyear on 24 Apr 21
     
    First, wearing masks is absolutely USELESS according to the science, now social distancing is useless. The scientists of the NIH, CDC are either terrible scientists or they have lied to us.
Nathan Goodyear

Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical... - 0 views

ascopubs.org/...JCO.19.01461

DVT pulmonary embolus deep venous thrombosis PE pulmonary emboli anti-coagulant cancer

shared by Nathan Goodyear on 04 Jul 21 - No Cached
  • Nathan Goodyear on 04 Jul 21
     
    Updated recommendations
Nathan Goodyear

Ozone in Medicine: The Low-Dose Ozone Concept-Guidelines and Treatment Strategies: Ozon... - 0 views

www.tandfonline.com/...01919512.2012.717847

MAH major autohemotherapy cancer rectal Ozone Ozone

shared by Nathan Goodyear on 26 Jul 23 - No Cached
  • Nathan Goodyear on 26 Jul 23
     
    Full pdf available in dropbox
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