Occupational Lead Poisoning - February 15, 1998 - American Family Physician - 0 views
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The freely diffusible plasma fraction is distributed extensively throughout tissues, reaching highest concentrations in bone, teeth, liver, lungs, kidneys, brain and spleen
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Inorganic lead does not undergo any metabolic transformation or digestion in the intestines, or detoxification in the liver.5
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The total bodily content of lead is called the body burden; in a steady state, about 90 percent of the body burden is bound to bone.2
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n general, lead is excreted quite slowly from the body (with the biologic half-life estimated at 10 years). Since excretion is slow, accumulation in the body occurs easily.2
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hronic toxicity is an insidious illness with protean manifestations.3,6 Symptoms may include arthralgias, headache, weakness, depression, loss of libido, impotence and vague gastrointestinal difficulties.