Celebrex useful in reducing colorectal polyps in individuals with familial adenomatous polyposis and in the treatment of cancer via induction of apoptosis and decrease in metastatic potential.
COX-2 is overexpressed in a variety of human cancers i.e. colorectal, prostate, lung adenocarcinoma. This study hightlights the increased tumor metastatic potential via upregulation of VEGF-C via EP1 and HER-2 dependent pathways. This upregulation was correlated with survival and mets.