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Nathan Goodyear

Caspase-1: is IL-1 just the tip of the ICEberg? - 0 views

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    Real nice review on Caspase-1
lina001

Daily Healthy Life Style - - 0 views

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    Best Health Tips and guideline for men and women....
Pursuit Of Healthy Living

Find the Best Holistic Weight Loss Program in Ladysmith BC - 1 views

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    Holistic Weight Loss is the next big thing in Health industry. Check out 6 Tips for gaining Holistic Weight Loss as suggested by a Natural Health Practitioner from Ladysmith BC Credits: Reflectiens.com (Holistic Healthcare in Ladysmith BC)
beautybycagla

healthy skin | Get Beauty Tips On - 0 views

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    As we get older, it is importаnt for us to tаke decent cаre of our skin. Exposure to sunlight аnd elements thаt аre distinct cаn wreаk hаvoc on it. This mаy leаd to premаture аging аnd other skin conditions. A skin cаre routine will surely help keep our skin looking fresh, young аnd hydrаted. These аre importаnt steps thаt you need to do аnd so, without further аdo, here is your guide to some bаsic skin cаre routine.
beautybycagla

Bаsic Skin Cаre Routine | Get Beauty Tips On - 0 views

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    Nathan healthy skin Growing up is something, everybody. You go through а lot of chаnges in your selection preference in clothes, of music, аnd so on аs you get older. However, your body undergoes а rаnge of chаnges thаt require the greаtest аmount of cаre аnd аttention. This is becаuse аt the stаrt of puberty, usuаlly between sixteen
modernsouq

مشد رجالى لإخفاء الكرش - مشد البطن للرجال بالسعودية - مودرن سوق - 0 views

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    أفضل مشد رجالى لإخفاء الكرش - مشد البطن رجالي كامل للجسم لتخسيس البطن والأرداف وتفتيت دهون البطن وإزالة الكرش حيث يجب إرتداء المشد الرجالى الحرارى حول منطقة البطن للرجال لتخفيف الكرش و إزالته و عودة البطن بالشكل الطبيعى إطلب الأن مشد رجالى لإخفاء الكرش - مشد البطن للرجال في السعودية والشحن ومجاناً
Nathan Goodyear

Broad targeting of angiogenesis for cancer prevention and therapy - 0 views

  • vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), interleukin-8 (IL-8), placental growth factor (PlGF), transforming growth factor-beta (TGFbeta), platelet derived growth factor (PDGF), angiopoietins (Angs) and others (reviewed in [4])
  • The switch may also involve down-regulation of endogenous inhibitors of angiogenesis such as endostatin, angiostatin or thrombospondin (reviewed in [5]) and has thus been regarded as the result of tipping the net balance between positive and negative regulators
  • There is a complex interrelationship between tumor hypoxia and tumor angiogenesis
  • ...17 more annotations...
  • chronic hypoxia
  • acute hypoxia
  • Environmental stress as a result of low oxygen and proper nutrient deprivation, such as glucose deprivation, are capable of inducing VEGF mRNA stabilization resulting in increased levels of the secreted ligand and angiogenic growth
  • HIFalpha subunits accumulate in the cytoplasm where they bind HIFbeta to form a heterodimer that subsequently translocates to the nucleus to activate transcription of target genes, including genes important for various processes such as metabolism (glucose transporter (GLUT)-1, hexokinase (HK)-1), cell growth (cyclin (CCN)-D1 [23]) and also angiogenesis, such as erythropoietin, VEGF and PDGF [24] (summarized in Fig. 1)
  • When oxygen levels are low (hypoxia; red arrow) PHDs cannot hydroxylate HIFalphas thereby allowing them to escape pVHL-mediated degradation. HIFalpha subunits accumulate and bind to their heterodimeric partner, HIFbeta, translocate into the nucleus and activate a cascade of hypoxic signaling first by the transcription of various target genes including microRNAs that are important for tumor promoting pathways
  • c-Src is also capable of activating HIFs by indirectly inhibiting PHD activity via the NADPH oxidase/Rac pathway.
  • mTOR can also promote stabilization and HIF transcriptional activity
  • hypoxia inducible factors (HIFs), heterodimeric transcription factors composed from alpha and beta subunits, which can be rapidly stabilized to fluidly adapt to and overcome the effects of a hypoxic environment
  • Curcumin inhibits the expression of epidermal growth factor receptor (EGFR), VEGFR-1, VEGFR-2 and VEGFR-3, and the kinase activity of Src and FAK, which are responsible for the induction of angiogenic genes as well as endothelial cell polarity and migration
  • Curcumin also reduces the MMP-2 and MMP-9 expression, along with the suppression of growth and invasion potential of tumor cells in culture and xenograft experiments
  • The expression of angiogenic biomarkers COX-2 and serum levels of VEGF were significantly reduced in the curcumin-treated group
  • Resveratrol inhibits capillary endothelial cell growth and new blood vessel growth in animals
  • interrupting cell proliferation, inducing apoptosis
  • [155] and impeding angiogenesis by suppressing VEGF expression through down-regulation of HIF-1alpha
  • resveratrol was reported to inhibit cell proliferation of human ovarian cancer cells and human osteosarcoma cells by attenuating HIF-1alpha
  • prevents cytokine-induced vascular leakage and tumor metastasis
  • The underlying molecular mechanisms include: blocking VEGF- and FGF-receptor-mediated MAPK activation, inhibiting Akt- and MAPK-driven HIF-1alpha basal expression and its induction by IGF-1, stimulating the proteasomal degradation of HIF-1alpha, inhibiting phosphatidyl inositol (PI)-3K/Akt and Ras/mitogen/extracellular signal-regulated kinase (MEK)/ERK pathways, and activation of forkhead box (FOX)O transcription factors
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    natural compounds to attach cancer explained.
Nathan Goodyear

Tips for writing a case report for the novice author - 0 views

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    Case study design
Eric Sean

Proper way : Barbell Bent Over Row - YouTube - 0 views

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    Barbell bent over row. There are two different variations that i'm going to show you. The first one is going to be coming directly up the legs and the other one is going to be bent over. Both of them, you want to make sure that you keep your back flat. You want to grab the bar, a little bit wider than shoulder-width apart. I use wraps because my grip isn't real good and after a while it starts to tire. So the wraps will help you to make sure that you get a good grip on it. So the first thing we're going to do, is we are going to go up directly up the legs. So we're going to grab the bar, straighten up, move back to our desired positioning. We're going to bend our waist, push your hips back, we're coming directly up the legs. Shoulders back, chest out.
pawankp

Cheap Health Insurance tips – Choose better plan for your Life.. - 0 views

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    Cheaphealthinsurancetips is an advisory website to make you secure and protected from possible eventuality & financial loss. This is nothing but a full of suggestion and complete details about almost all insurance companies which helps us in understanding the fact of an insurance policy. This website helps us to know about all brands of insurance company and their policies. In fact, not only policy rather you have an option to talk to a representative of that particular brand (Insurance Company) by just giving you basics information like phone number and email address. After talking to a company executive you may ask them to come to your address and give you the complete details before you decide to take any type of insurance.
Nathan Goodyear

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern i... - 0 views

  • In skeletal muscle, HDAC4 has been found to be exported from the nucleus during exercise, suggesting that removal of the transcriptional repressive function could be a mechanism for exercise adaptation [50]. For HDAC4, we observed increased levels of DNA methylation and a simultaneous decrease in mRNA expression in adipose tissue in response to the exercise intervention. Additionally, the functional experiments in cultured adipocytes suggested increased lipogenesis when Hdac4 expression was reduced
  • NCOR2 also exhibited increased levels of DNA methylation and a simultaneous decrease in mRNA expression in adipose tissue in response to the exercise intervention, and furthermore we observed increased lipogenesis when Ncor2 expression was down regulated in the 3T3-L1 cell line. NCOR2 is a nuclear co-repressor, involved in the regulation of genes important for adipogenesis and lipid metabolism, and with the ability to recruit different histone deacetylase enzymes, including HDAC4
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    Study finds 6 month exercise program in men induced epigenetic change via DNA methylation of CPG islands in adipose cells effecting metabolism and altering obesity and type II diabetes risk.  The study looked at 2 genes: HDAC4 and NCOR2 and found that exercise decreased expression via methylation altering adipogenesis and lipid metabolism.
fitspresso

https://www.sightcare-co.com/ - 0 views

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    Sight Care | Official Site sightcare-co.com · by Sight Care Sight Care Only $49/Bottle Limited Time Offer! Sight Care Special Deal + Special 67% Discount Save $600 + 180 Days Money Back Guarantee #1.The Sight Care vision supplement is a dietary supplement for helping you improve your vision and brain health. Sight Care eye supplements are formulated to provide a synergistic blend of vitamins, minerals, antioxidants, and other bioactive compounds that are essential for maintaining healthy vision Regular Price: 147/per bottle Only for: $49/per bottle What Is Sight Care? This powerful vision support supplement is made with a unique blend of natural ingredients and plant extracts that work together synergistically to deliver numerous benefits for your brain and eye health. With Sight Care, you can expect to experience increased energy levels, improved eyesight, and an overall revitalized sense of well-being. Taking care of your vision health is not just about seeing clearly; it's also about maintaining your overall brain health. As we age, our vision deteriorates, and our eyes and brain can experience a decline in function, but there are steps you can take to support your visual and cognitive health. Regular eye exams are crucial for detecting and treating vision problems early on, and making healthy choices such as eating a nutritious diet and exercising regularly can also help. However, with busy schedules, it can be difficult to find the time to devote to a healthy lifestyle. This is where the Sight Care supplement comes in. It's designed to support both vision and brain health with its blend of natural ingredients that have been shown to promote healthy vision and cognitive function You must not compromise your eye health for momentary exhilaration. If you are glued to digital screens day and night, you must take measures to prevent eye diseases like age-related macular degeneration. The SightCare vision supplement has been made using 100% natura
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