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Nathan Goodyear

The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A... - 0 views

www.ncbi.nlm.nih.gov/...PMC9925039

COVID-19 SARS-CoV-2 COVID WBC ascorbic acid vitamin C

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • vitamins A, B, C, E, B6, B12, folate, zinc, iron, copper, and selenium
  • White blood cells, including neutrophils and monocytes, accumulate concentrations of vitamin C up to 100 times greater than that of plasma
  • Vitamin C is a crucial component of both the innate (nonspecific) and adaptive (specific) portions of the immune system
  • ...52 more annotations...
  • play a role during the initial chemotactic response of neutrophils shortly after infection
  • following vitamin C supplementation, a 20% increase in neutrophil chemotactic activity was observed
  • also contributes to the phagocytosis and killing of microbes by neutrophils
  • low levels of vitamin C occurring in high-stress situations
  • maturation, proliferation, and viability of T cells have all been shown to be upregulated by the presence of normal physiologic concentrations of vitamin C
  • Vitamin C has been shown to directly affect the number of Igs released from B cells
  • vitamin C among healthy young adult males showed a significant increase in serum levels of IgA, IgG, and IgM
  • effects of high-dose vitamin C on cytokine levels in cancer patients, finding decreased amounts of the cytokines Interleukin-1 alpha (IL-1 alpha), IL-2, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after high-dose vitamin C infusion
  • when vitamin C was supplemented with vitamin E in healthy adults, it increased the production of cytokines IL-1 beta and TNF-alpha
  • vitamin C acts to modulate the levels of cytokines to prevent them from fluctuating in either direction
  • vitamin C also acts as an important antioxidant to the cells of the immune system.
  • human leukocytes, neutrophils, in particular, possess the ability to transport the oxidized form of vitamin C across its membrane to use as a defense mechanism against ROS produced during an immune response
  • Vitamin C also can recover other endogenous antioxidants in the body such as vitamin E and glutathione, returning them to their active state
  • vitamin C can decrease the activation of NF-kB
  • can reduce harmful nitrogen-based compounds such as N-nitrosamines and nitrosamides, both of which are carcinogenic 
  • subjects taking oral vitamin C supplementation saw a 60% to 90% reduction in oxidative stress compared to a placebo control
  • subjects infused with vitamin C alone had a 516% increase in glutathione levels compared to subjects not provided the 500 mg daily supplementation
  • hydroxylating proline and lysine
  • mature and stabilize the tissue of a healing wound
  • healing
  • oral surgery
  • improved soft tissue regeneration
  • vitamin C increases the mRNA levels of type I and type III collagen in the human dermis
  • Studies have demonstrated that those with low levels of vitamin C are at a significantly higher risk of respiratory infection compared to those with normal levels
  • viral cold duration was reduced by about 8% in adults and 13.5% in children using prophylactic daily doses of 200 mg of oral vitamin C
  • prophylactically supplementing vitamin C decreases the risk of infection with respiratory viruses such as the common cold
  • combined with probiotics, oral vitamin C supplementation showed a 33% decrease in the incidence of respiratory tract infections in preschool-age children [
  • high-dose oral supplementation of vitamin C managed to prevent or reduce symptoms if taken before or just after the onset of cold- or flu-like symptoms
  • improvements in oxygen saturation and decreased IL-6 levels (a marker of inflammation) in the treatment group compared to the control group
  • 8 g doses of oral vitamin C
  • there is a negative correlation between age and serum levels of vitamin C
  • Patients with COVID-19 will likely also experience depletion in serum levels of vitamin C as a direct result of the upregulation of the immune system to combat the infection
  • Colunga et al. suggested that oral vitamin C can be combined with oral Quercetin, an antiviral flavonoid, to improve Quercetin’s ability to block viral membrane fusion of SARS-CoV-2
  • high doses of 1-2 g/day of oral vitamin C could prevent other upper respiratory infections
  • It appears vitamin C supplementation by itself does not provide a striking benefit in preventing COVID-19 infection for those without a deficiency
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Flawed statement. What is normal? Vitamin D. Many variables effect levels and dose, including the two compartment kinetics and absorption.
  • Hiedra et al. were able to show decreases in inflammatory biomarkers, such as D-dimer and ferritin
  • some evidence to support that prophylactic use of vitamin C helps reduce the severity of respiratory infection symptoms once a subject has already been infected
  • oral vitamin C in combination with zinc provided the largest amount of antibody titers 42 days
  • linear relationship between days of vitamin C therapy and survival duration
  • other studies were unable to find any definitive improvement concerning therapy with vitamin C
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Either these studies are designed to fail or the authors are lacking some basic understanding of pharmacokinetics and pharmacodynamics with vitamin C.
  • Fowler et al. aimed to see if a high-dose vitamin C infusion would benefit patients affected by ARDS, but they were unable to conclude that vitamin C infusion, compared to a placebo, could decrease vascular inflammation and damage in ARDS
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      At what dose, duration, frequency???
  • in a sample of 67 COVID-19-positive ICU patients, 82% of them displayed plasma vitamin C levels below 0.4 mg/dL
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      They are kind of make the point from my earlier note.
  • continuous vitamin C infusion at a rate of 60 mg/kg/day for four days decreased the need for mechanical ventilation and vasopressor use but had no significant effect on overall mortality
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Again, designed to fail or ignorance designed the study which failed
  • Carr et al. suggested that high-dose IV vitamin C is most effective when treating sepsis as septic patients receiving the normal daily recommendations through diet still showed decreased vitamin C levels
  • High-dose IV vitamin C treatment has also been shown by Kakodkar et al. to decrease syndecan-1, an endothelial glycocalyx that contributes to mortality in septic patients
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • reduced overall mortality
  • reduced overall mortality
  • propose the use for high-dose vitamin C to aid in the treatment of septic shock-induced hypotension
  • treatment of severe sepsis using a high dose (up to 200 mg/kg/day) of IV vitamin C was explored in phase I, a double-blind, randomized, placebo-controlled trial by Fowler et al. [75]. Their findings included a reduction in SOFA scores and decreased vascular injury compared to a placebo control group, all while showing minimal adverse side effects
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      High dose here is laughable. Again, duration and frequency also.
  • Maintaining a daily intake of 75 and 100 mg for men and women, respectively, as recommended by the U.S. Institute of Medicine
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      This recommendation is FRANK IGNORANCE
indian-health

India's Best VSD Surgeons Bringing Brighter Futures for Babies Born with Heart Defects - 0 views

www.apsense.com/...s-born-with-heart-defects.html

India's Best VSD Surgeons VSD Surgeons in India Ventricular septal defect Top VSD Surgeons in India Top 10 VSD Surgeons of India Ventricular Septal Defect Surgery India Cost of Ventricular Septal Defect Surgery India Affordable Ventricular Septal Defect S

shared by indian-health on 06 Aug 22 - No Cached
  • indian-health on 06 Aug 22
     
    Ventricular septal defect surgery cost in India has gained popularity due to the cost effective procedure. They are up to 50% much less as compared to other developed countries
spineneuro

French to India Medical Travel: Un spécialiste de la colonne vertébrale à Nan... - 0 views

frenchtoindiamedicaltravel.blogspot.com/...rds-better-hospital-india.html

Spécialiste de la colonne vertébrale à Nanavati Mumbai Dr Mihir Bapat

shared by spineneuro on 14 Oct 22 - No Cached
  • spineneuro on 14 Oct 22
     
    Le spécialiste de la colonne vertébrale à Nanavati Mumbai est un chirurgien de la colonne vertébrale très renommé à Mumbai, en Inde, qui s'efforce de fournir les traitements médicaux de la colonne vertébrale les plus avancés possibles, basés sur des pratiques utilisant les dernières technologies chirurgicales.
harshitatyagi

What is Endo's belly, And how can you prevent it? - 0 views

fortunetelleroracle.com/...-how-can-you-prevent-it-664968

endo belly endometriosis Endometriosis symptoms endometriosis treatment Endo Belly Treatment

shared by harshitatyagi on 30 Aug 22 - No Cached
  • harshitatyagi on 30 Aug 22
     
    Endo's belly is a term used to describe the bloating, pain, and swelling that arises with the existence of endometriosis tissue. Endo belly often causes several hindrances in women of reproductive age, making them infertile for the rest of their lives. Visit the link to know why it occurs, and prevent the conditions of the Endo Belly by making certain changes.
spineneuro

India's Top Brain Tumor Surgeons: Heroes of Hope and Healing - 0 views

steemit.com/...ons-heroes-of-hope-and-healing

Brain Tumor Brain Tumor surgery Brain Tumor surgery cost

shared by spineneuro on 15 Nov 23 - No Cached
  • spineneuro on 15 Nov 23
     
    India stands out as the preferred destination for patients from across the globe, thanks to the country's highly knowledgeable and skilled brain tumor surgeons India who offer advanced and innovative treatment options.
spineneuro

বাংলাদেশ স্বাস্থ্য নিউজ আপডেট - সংবাদ মাধ্যম: ভারতের শীর্ষ ব্রেন টিউমার সার্জ... - 0 views

bangladeshhealthnews.blogspot.com/...eroes-of-hope-and-healing.html

ব্রেন টিউমার সার্জন ভারত মস্তিষ্কের টিউমার সার্জারি

shared by spineneuro on 27 Nov 23 - No Cached
  • spineneuro on 27 Nov 23
     
    ভারত সারা বিশ্বের রোগীদের জন্য পছন্দের গন্তব্য হিসাবে দাঁড়িয়েছে, দেশের উচ্চ জ্ঞানসম্পন্ন এবং দক্ষ ব্রেন টিউমার সার্জন ভারতকে ধন্যবাদ যারা উন্নত এবং উদ্ভাবনী চিকিত্সার বিকল্পগুলি অফার করে।
spineneuro

Your Spine's Best Friend: Dr. Vidyadhara in Bangalore - 0 views

www.briefingwire.com/...end-dr-vidyadhara-in-bangalore

Dr. Vidyadhara in Bangalore best spine surgeon in Bangalore Dr. Vidyadhara S

shared by spineneuro on 08 Nov 23 - No Cached
  • spineneuro on 08 Nov 23
     
    Dr. Vidyadhara S's multi-disciplinary approach to care ensures that you, as the patient, receive the best possible treatment. He performs more outpatient, minimally invasive spine surgeries each month than any other spine surgeon globally. The best spine surgeon in Bangalore is well-equipped to offer advice, recommendations, and spine surgery procedures to help you regain a full and comfortable life.
Nathan Goodyear

Sars-Cov-2 Kills T-Cells, Just Like HIV - by Igor Chudov - 0 views

igorchudov.substack.com/...-cov-2-kills-t-cells-just-like

ACE2 immune system T cells cancer SAR T lymphocytes COVID SARS-CoV-2

shared by Nathan Goodyear on 17 Mar 22 - No Cached
  • Nathan Goodyear on 17 Mar 22
     
    Just an article.
spineneuro

বাংলাদেশ স্বাস্থ্য নিউজ আপডেট - সংবাদ মাধ্যম: দ্য ভেরি বেস্ট ইন স্পাইন কেয়ার... - 0 views

bangladeshhealthnews.blogspot.com/...gins-with-dr-vidyadhara-s.html

ডাঃ বিদ্যাধারা এস শীর্ষ মেরুদণ্ড বিশেষজ্ঞ মনিপাল হাসপাতাল ব্যাঙ্গালোর শীর্ষস্থানীয় মেরুদণ্ড বিশেষজ্ঞ

shared by spineneuro on 14 May 22 - No Cached
  • spineneuro on 14 May 22
     
    ডাঃ বিদ্যাধারা এস ভারতে মেরুদণ্ডের যত্নের জন্য প্রধান পছন্দ। শীর্ষস্থানীয় মেরুদন্ড বিশেষজ্ঞ মণিপাল হাসপাতাল ব্যাঙ্গালোর আপনার সমস্যার একটি পুঙ্খানুপুঙ্খ এবং সম্পূর্ণ মূল্যায়ন এবং উপযুক্ত সিদ্ধান্ত নেওয়ার অনুমতি দিয়ে একটি ব্যাপক মূল্যায়ন প্রক্রিয়া প্রদান করে।
Nathan Goodyear

Low-Dose Chemotherapy with Insulin (Insulin Potentiation Therapy) in Combination with H... - 0 views

www.ncbi.nlm.nih.gov/...PMC3357525

prostate cancer IPTLD low-dose chemotherapy cancer chemotherapy insulin potentiation therapy LDMC low-dose metronomic chemotherapy IPT

shared by Nathan Goodyear on 25 Jan 18 - No Cached
  • The method of insulin potentiation therapy was empirically invented in 1930 from Mexican doctor D. Perez Garsia
  • increases the permeability of cell membrane
  • influences the metabolic processes in human body with the increase of the regenerating processes
  • ...9 more annotations...
  • facilitates the transport of intra and extra cellular liquids which helps the organism to eliminate the toxic products
  • The increased number of insulin receptors on the tumor cell, in comparison to the normal one, allows the before mentioned 2 factors to act predominantly
  • Increased permeability after the insulin effect on the cellular membrane results in increased intracellular quantity of antitumor agents
  • have other endocrine effects: directly stimulates suprarenal gland to produce epinephrine and glucocorticoid hormones and stimulates ACTH secretion. These endocrine effects also have a positive influence on the regenerating processes
  • Insulin influences the intracellular metabolism of the tumor cell, which leads to increase of the number of cells in phase S, where they are with highly sensitive to specific chemotherapeutics.
  • After the first 6 IPT applications overall (groups A and B) response to treatment on PSA criteria shows partial effect and stabilization in 12 of 16 (75%) patients
  • After the 10th IPTLD application or 3 months after starting treatment, complete response, partial response, and stabilization were observed in 4 of 9 (66.6%), while in 3 of 9 (33.3%) was registered complete effect
  • the advanced stage of disease in patients treated
  • Quality of life after the second IPTLD application is significantly improved
  • Nathan Goodyear on 25 Jan 18
     
    IPT found to be effextive in treated castrate-resistant prostate cancer.
spineneuro

রুয়ান্ডা থেকে দিল্লি: ভারতের সেরা গামা ছুরি নিউরোসার্জনের সাথে এমবোনেকো ত্বা... - 0 views

healthtourtoindiafrombangladesh.blogspot.com/...nife-neurosurgeon-in-indi.html

দিল্লির সেরা গামা ছুরি নিউরোসার্জন গামা ছুরি রেডিওসার্জারি

shared by spineneuro on 20 Apr 24 - No Cached
  • spineneuro on 20 Apr 24
     
    ভারতের দিল্লিতে সেরা গামা ছুরি নিউরোসার্জনের সাথে এমবোনেকো ত্বাহিরওয়া-এর অভিজ্ঞতা, উন্নত চিকিৎসা প্রযুক্তি, বিশেষজ্ঞের যত্ন, এবং সাশ্রয়ী মূল্যের গামা ছুরি রেডিওসার্জারি খরচ ভারতে একত্রিত করে।
Nathan Goodyear

The Veterans ECS21 (Exploring Cannabigerol for Sleep) Study: A protocol for the first r... - 0 views

www.medrxiv.org/...2023.03.13.23287212v1.full

phytocannabinoids CBG cannabigerol

shared by Nathan Goodyear on 20 Apr 24 - No Cached
  • Nathan Goodyear on 20 Apr 24
     
    Safe @ doses of CBG 25-50 mg in veterans.
spineneuro

من رواندا إلى دلهي: رحلة مونيكو تواهيروا مع أفضل جراح أعصاب غاما نايف في الهن... - 0 views

spineandneuroindia.blogspot.com/...ife-neurosurgeon-in-india.html

أفضل جراح أعصاب جاما نايف في دلهي أفضل جراح أعصاب في دلهي الجراحة الإشعاعية بسكين جاما

shared by spineneuro on 24 Apr 24 - No Cached
  • spineneuro on 24 Apr 24
     
    في الختام، فإن تجربة مبونيكو تواهيروا مع أفضل جراح أعصاب غاما نايف في دلهي، الهند، تلخص التقارب بين التكنولوجيا الطبية المتقدمة، والرعاية المتخصصة، والجراحة الإشعاعية بسكين جاما بأسعار معقولة في الهند.
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