Other targets of HIF-1α include glucose transporter-1 (GLUT-1), the main transporter
involved in glucose uptake [9,10]; lactate dehydrogenase V (LDHV), which is responsible for the conversion of pyruvate
into lactate; pyruvate dehydrogenase kinase isozyme 1 (PDK1), which is responsible
for the phosphorylation and consequent inactivation of pyruvate dehydrogenase (PDH);
and carbonic anhydrase IX (CAIX), a hypoxia-related protein involved in pH regulation
[11]. Alpha-methylacyl-CoA racemase (AMACR), pristanoyl-CoA oxidase (ACOX-3) and D-bifunctional
protein (DBP), are also important fatty acid oxidation-related proteins in prostate
cancer