Differential Effects of Dehydroepiandrosterone and Testosterone in Prostate and Colon C... - 0 views
press.endocrine.org/...en.2012-2249
testosterone prostate colon colon cancer cancer NGF nerve growth factor dhea dehydroepiandrosterone
shared by Nathan Goodyear on 19 Nov 14
- No Cached
-
Several studies indicate that DHEA may enhance cancer-promoting activities in several prostate cancer cell lines acting as agonist or antagonist for the intracellular AR
-
the estrogenic metabolites of DHEA, 5a-androstane-3b, 17b-diol (3b-Adiol) and E2 bind to estrogen receptors but not to AR
- ...16 more annotations...
-
Different members of neurotrophins are expressed during cancer progression, suggesting their involvement in cell proliferation, anoikis protection, and malignancy
-
Regulation of the apoptotic machinery in prostate and colon cancer cells by testosterone occurs rapidly and is initiated at the plasma membrane level through specific membrane-binding sites not involving the classical cytoplasmic AR
-
testosterone antagonizes the prosurvival effects of DHEA in neuronal cells, blocking its binding to NGF receptors
-
elevated levels of DHEA or its sulfate ester DHEA-sulfate in young adults are associated to low incidence of androgen-dependent tumors
-
The decline of DHEA with aging may contribute to prostate cancer progression associated with advanced age
-
DHEA is an effective antiapoptotic factor, reversing the serum deprivation-induced apoptosis in prostate cancer cells (DU145 and LNCaP cell lines) as well as in colon cancer cells
-
exposure of prostate DU145 and colon Caco2 cancer cells to testosterone totally blocked the protective effects of both DHEA and NGF. These findings suggest that testosterone acts as an antagonist of DHEA and NGF
-
These findings support the hypothesis that testosterone may inhibit cancer cell growth by antagonizing the proliferative, antiapoptotic effects of endogenous factors, such as DHEA or NGF, in the case of prostate and colon cancer cells