The Androgen Derivative 5α-Androstane-3β,17β-Diol Inhibits Prostate Cancer Ce... - 0 views
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the dihydrotestosterone metabolite 5α-androstane-3β,17β-diol (3β-Adiol), a steroid which does not bind androgen receptors, but efficiently binds the estrogen receptor β (ERβ), exerts a potent inhibition of prostate cancer cell migration through the activation of the ERβ signaling
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estradiol is not active
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3β-Adiol, through ERβ, induces the expression of E-cadherin, a protein known to be capable of blocking metastasis formation in breast and prostate cancer cells
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DHT metabolite 3-beta androstanediol inhibits prostate cancer via its interaction with ER beta not AR. This study finds increased E-cadherin transcription to reduce metastasis. Estrogen was not active, according to this study. This implies that estrogen in early disease may have a different signal than late.