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harshitatyagi

Get All The Answers for Queries Regarding Ovulation - Crysta IVF - 0 views

www.launchora.com/...for-queries-regarding-ovulatio

Ovulation Ovulation Symptoms Ovulation Signs Ovulation Calender Ovulation Tracker Ovulation Calculator Ovulation Days Ovulation cycle What happen during Ovulation Ovulation period for pregnancy

shared by harshitatyagi on 17 Oct 22 - No Cached
  • harshitatyagi on 17 Oct 22
     
    Ovulation is when a female's body releases an egg from the ovary so that sperm can fertilize it to complete the reproduction process effectively. Hence, in this article, we will cover all the essential details regarding ovulation, its signs and symptoms, and how long it lasts.
Nathan Goodyear

Testosterone: a vascular hormone in health and disease - 0 views

joe.endocrinology-journals.org/...R47.full

testosterone hormone health disease hormones men male cardiovascular disease CVD

shared by Nathan Goodyear on 13 May 13 - No Cached
  • Testosterone has beneficial effects on several cardiovascular risk factors, which include cholesterol, endothelial dysfunction and inflammation
  • In clinical studies, acute and chronic testosterone administration increases coronary artery diameter and flow, improves cardiac ischaemia and symptoms in men with chronic stable angina and reduces peripheral vascular resistance in chronic heart failure.
  • testosterone is an L-calcium channel blocker and induces potassium channel activation in vascular smooth muscle cells
  • ...54 more annotations...
  • Animal studies have consistently demonstrated that testosterone is atheroprotective, whereas testosterone deficiency promotes the early stages of atherogenesis
  • there is no compelling evidence that testosterone replacement to levels within the normal healthy range contributes adversely to the pathogenesis of CVD (Carson & Rosano 2011) or prostate cancer (Morgentaler & Schulman 2009)
  • bidirectional effect between decreased testosterone concentrations and disease pathology exists as concomitant cardiovascular risk factors (including inflammation, obesity and insulin resistance) are known to reduce testosterone levels and that testosterone confers beneficial effects on these cardiovascular risk factors
  • Achieving a normal physiological testosterone concentration through the administration of testosterone replacement therapy (TRT) has been shown to improve risk factors for atherosclerosis including reducing central adiposity and insulin resistance and improving lipid profiles (in particular, lowering cholesterol), clotting and inflammatory profiles and vascular function
  • It is well known that impaired erectile function and CVD are closely related in that ED can be the first clinical manifestation of atherosclerosis often preceding a cardiovascular event by 3–5 years
  • no decrease in the response (i.e. no tachyphylaxis) of testosterone and that patient benefit persists in the long term.
  • free testosterone levels within the physiological range, has been shown to result in a marked increase in both flow- and nitroglycerin-mediated brachial artery vasodilation in men with CAD
  • Clinical studies, however, have revealed either small reductions of 2–3 mm in diastolic pressure or no significant effects when testosterone is replaced within normal physiological limits in humans
  • Endothelium-independent mechanisms of testosterone are considered to occur primarily via the inhibition of voltage-operated Ca2+ channels (VOCCs) and/or activation of K+ channels (KCs) on smooth muscle cells (SMCs)
  • Testosterone shares the same molecular binding site as nifedipine
  • Testosterone increases the expression of endothelial nitric oxide synthase (eNOS) and enhances nitric oxide (NO) production
  • Testosterone also inhibited the Ca2+ influx response to PGF2α
  • one of the major actions of testosterone is on NO and its signalling pathways
  • In addition to direct effects on NOS expression, testosterone may also affect phosphodiesterase type 5 (PDE5 (PDE5A)) gene expression, an enzyme controlling the degradation of cGMP, which acts as a vasodilatory second messenger
  • the significance of the action of testosterone on VSMC apoptosis and proliferation in atherosclerosis is difficult to delineate and may be dependent upon the stage of plaque development
  • Several human studies have shown that carotid IMT (CIMT) and aortic calcification negatively correlate with serum testosterone
  • t long-term testosterone treatment reduced CIMT in men with low testosterone levels and angina
  • neither intracellular nor membrane-associated ARs are required for the rapid vasodilator effect
  • acute responses appear to be AR independent, long-term AR-mediated effects on the vasculature have also been described, primarily in the context of vascular tone regulation via the modulation of gene transcription
  • Testosterone and DHT increased the expression of eNOS in HUVECs
  • oestrogens have been shown to activate eNOS and stimulate NO production in an ERα-dependent manner
  • Several studies, however, have demonstrated that the vasodilatory actions of testosterone are not reduced by aromatase inhibition
  • non-aromatisable DHT elicited similar vasodilation to testosterone treatment in arterial smooth muscle
  • increased endothelial NOS (eNOS) expression and phosphorylation were observed in testosterone- and DHT-treated human umbilical vein endothelial cells
  • Androgen deprivation leads to a reduction in neuronal NOS expression associated with a decrease of intracavernosal pressure in penile arteries during erection, an effect that is promptly reversed by androgen replacement therapy
  • Observational evidence suggests that several pro-inflammatory cytokines (including interleukin 1β (IL1β), IL6, tumour necrosis factor α (TNFα), and highly sensitive CRP) and serum testosterone levels are inversely associated in patients with CAD, T2DM and/or hypogonadism
  • patients with the highest IL1β concentrations had lower endogenous testosterone levels
  • TRT has been reported to significantly reduce TNFα and elevate the circulating anti-inflammatory IL10 in hypogonadal men with CVD
  • testosterone treatment to normalise levels in hypogonadal men with the MetS resulted in a significant reduction in the circulating CRP, IL1β and TNFα, with a trend towards lower IL6 compared with placebo
  • parenteral testosterone undecanoate, CRP decreased significantly in hypogonadal elderly men
  • Higher levels of serum adiponectin have been shown to lower cardiovascular risk
  • Research suggests that the expression of VCAM-1, as induced by pro-inflammatory cytokines such as TNFα or interferon γ (IFNγ (IFNG)) in endothelial cells, can be attenuated by treatment with testosterone
  • Testosterone also inhibits the production of pro-inflammatory cytokines such as IL6, IL1β and TNFα in a range of cell types including human endothelial cells
  • decreased inflammatory response to TNFα and lipopolysaccharide (LPS) in human endothelial cells when treated with DHT
  • The key to unravelling the link between testosterone and its role in atherosclerosis may lay in the understanding of testosterone signalling and the cross-talk between receptors and intracellular events that result in pro- and/or anti-inflammatory actions in athero-sensitive cells.
  • testosterone functions through the AR to modulate adhesion molecule expression
  • pre-treatment with DHT reduced the cytokine-stimulated inflammatory response
  • DHT inhibited NFκB activation
  • DHT could inhibit an LPS-induced upregulation of MCP1
  • Both NFκB and AR act at the transcriptional level and have been experimentally found to be antagonistic to each other
  • As the AR and NFκB are mutual antagonists, their interaction and influence on functions can be bidirectional, with inflammatory agents that activate NFκB interfering with normal androgen signalling as well as the AR interrupting NFκB inflammatory transcription
  • prolonged exposure of vascular cells to the inflammatory activation of NFκB associated with atherosclerosis may reduce or alter any potentially protective effects of testosterone
  • DHT and IFNγ also modulate each other's signalling through interaction at the transcriptional level, suggesting that androgens down-regulate IFN-induced genes
  • (Simoncini et al. 2000a,b). Norata et al. (2010) suggest that part of the testosterone-mediated atheroprotective effects could depend on ER activation mediated by the testosterone/DHT 3β-derivative, 3β-Adiol
  • TNFα-induced induction of ICAM-1, VCAM-1 and E-selectin as well as MCP1 and IL6 was significantly reduced by a pre-incubation with 3β-Adiol in HUVECs
  • 3β-Adiol also reduced LPS-induced gene expression of IL6, TNFα, cyclooxygenase 2 (COX2 (PTGS2)), CD40, CX3CR1, plasminogen activator inhibitor-1, MMP9, resistin, pentraxin-3 and MCP1 in the monocytic cell line U937 (Norata et al. 2010)
  • This study suggests that testosterone metabolites, other than those generated through aromatisation, could exert anti-inflammatory effects that are mediated by ER activation.
  • The authors suggest that DHT differentially effects COX2 levels under physiological and pathophysiological conditions in human coronary artery smooth muscle cells and via AR-dependent and -independent mechanisms influenced by the physiological state of the cell
  • There are, however, a number of systematic meta-analyses of clinical trials of TRT that have not demonstrated an increased risk of adverse cardiovascular events or mortality
  • The TOM trial, which was designed to investigate the effect of TRT on frailty in elderly men, was terminated prematurely as a result of an increased incidence of cardiovascular-related events after 6 months in the treatment arm
  • trials of TRT in men with either chronic stable angina or chronic cardiac failure have also found no increase in either cardiovascular events or mortality in studies up to 12 months
  • Evidence may therefore suggest that low testosterone levels and testosterone levels above the normal range have an adverse effect on CVD, whereas testosterone levels titrated to within the mid- to upper-normal range have at least a neutral effect or, taking into account the knowledge of the beneficial effects of testosterone on a series of cardiovascular risk factors, there may possibly be a cardioprotective action
  • The effect of testosterone on human vascular function is a complex issue and may be dependent upon the underlying androgen and/or disease status.
  • the majority of studies suggest that testosterone may display both acute and chronic vasodilatory effects upon various vascular beds at both physiological and supraphysiological concentrations and via endothelium-dependent and -independent mechanisms
  • Nathan Goodyear on 13 May 13
     
    Good deep look into the testosterone and CVD link.
Justin Broods

Excellent And Professional Medical Call Center Service Provider - 1 views

I am one of those medical director out there who hired a Nurse Call Center to take some of my patient's calls. As a director, taking calls is not my duty, I have to give my attention also to my in...

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started by Justin Broods on 07 Aug 13 no follow-up yet
felipp windsor

Thank You The Dental Co. - 1 views

I was deeply worried when I noticed that my 9 year-old daughter got some problems with her teeth. I then brought her to a nearby dentist, but I found out that she was not that capable of answering ...

started by felipp windsor on 30 Sep 13 no follow-up yet
Nathan Goodyear

Product Information > Lipstick and Lead: Questions and Answers - 0 views

www.fda.gov/...ucm137224.htm

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shared by Nathan Goodyear on 19 Feb 11 - No Cached
  • FDA Analyses of Lead in Lipsticks
  • Nathan Goodyear on 19 Feb 11
     
    FDA finds lead in all lipsticks
Meredith Blige

How Can I Stop Snoring? - 1 views

Snoring is really getting in the way of my married life. Every time I sleep my wife keeps on complaining about my disturbing snores. So I often have to sleep on the couch. I often ask myself on Ho...

Snoring

started by Meredith Blige on 23 Aug 11 no follow-up yet
becomea paramedic

I Passed The Paramedic Recruitment Process on My First Attempt - 1 views

I really wanted to become a paramedic in the UK. That is why I went online and sought out the help of HowToBecomeAParamedic. They gave me useful insider tips, advice and products (which I bought,...

become a paramedic

started by becomea paramedic on 29 Sep 11 no follow-up yet
Nathan Goodyear

ScienceDirect - American Psychologist : Medicare's Search for Effective Obesity Treatme... - 0 views

www.sciencedirect.com/...S0003066X07678289

Diet weight loss overweight health benefits

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • These studies show that one third to two thirds of dieters regain more weight than they lost on their diets, and these studies likely underestimate the extent to which dieting is counterproductive because of several methodological problems,
  • there is little support for the notion that diets lead to lasting weight loss or health benefits.
  • Nathan Goodyear on 09 Jul 11
     
    "diet' show no lasting benefit in weight loss and health benefits.  In fact, 66% of individuals weigh more than they started after 2 years.
Nathan Goodyear

Questions and answers on the role of faecal calprotectin as a biological marker in infl... - 0 views

www.sciencedirect.com/...S1590865808001916

Calprotectin inflammation IBD colorectal cancer infection disease

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    Calprotectin is a useful biomarker in IBD.  Colorectal cancer and GI infection can also increase fecal Calprotectin. 
marclipman18

https://buyambienonline.org/ Buy Ambien Online From Brightway Pharmacy - 0 views

We are trained and Licensed Medical Personnel Specialized in the Supply of Ambien and other Sleeping Medications.We are Involved in the Supply of 100% Genuine and Authentic Medications FDA Approved...

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started by marclipman18 on 10 Dec 18 no follow-up yet
fnfdoc

Risk Factors For Alzheimer's | Health Blog - 0 views

www.fnfdoc.com/...risk-factors-alzheimers

Alzheimer Alzheimer's Dementia

shared by fnfdoc on 22 May 18 - No Cached
  • fnfdoc on 22 May 18
     
    Alzheimer's is a mental illness that mostly affects the elderly. It is characterized by dementia, cognitive impairment, and mood swings. The patient gradually fades into a state of perpetual darkness and lack of self-awareness. Here are some steps we can take to reduce our own risk.
  • fnfdoc on 22 May 18
     
    Scientists are trying to find ways to prevent Alzheimer's before it comes knocking at your doorstep. Extensive research is taking place even as you read this. Everyone hopes to put together the answer before it becomes a global issue. Here are a few risk factors that you can and can't avoid:
trungtamnamkhoa

Learn About Male Foreskin Disease - Men's Health Clinic - 1 views

menhealth.vn/...bao-quy-dau

hormone Testosterone Men Disease Male cancer health healthy

shared by trungtamnamkhoa on 25 Jun 19 - No Cached
  • trungtamnamkhoa on 25 Jun 19
     
    Long foreskin It was a situation in which he was always so shy when he opened his eyes even though he could easily go out easily, without pain, without tightening. Even when "greeting the flag" he kept hiding the ball under the glans or just poking out. Must have to wait for the hand of "big brother" to slide down to bear the road to see the world around. When you have a clear understanding of the above concepts, the men of the race race to wonder, "Why is the foreskin of my friend not narrowed but why are my and my brother's bad luck?". The doctor asked for the correct answer, partly because of his bad luck, from birth to growing up, the foreskin was like that, "keep loving and protecting the foreskin." But it is not uncommon for other reasons to make men suffer because of foreskin: First, we have to recall the untimely and improper foreskin effects of parents when children are young. It is these overly "anxious" actions of parents that have counterproductive and narrowed down the latter. There are some autoimmune diseases, making the foreskin a fibrous day, loss of elasticity, gradually worsening, called BXO (balanitisxerotica obliterans) - a narrowed glans. This can also be interpreted as a form of glans, which can even cause narrowing of the urinary tract to lead to urinary retention. Some cases of glans and foreskin have been repeatedly infected by microbiological agents (bacteria, viruses, fungi, etc.), which can be re-infected and non-stop treatment is also available. can lead to complications of fibrosis and secondary stenosis
trungtamnamkhoa

Penis enlargement due to where? Cause And Treatment - 1 views

trungtamnamkhoa.com/n-duong-vat-noi-mun-trang.html

penis pimples white acne male men health healthy cancer Testosterone hormone

shared by trungtamnamkhoa on 25 Jun 19 - No Cached
  • trungtamnamkhoa on 25 Jun 19
     
    The body of the white pimples is a common feature of boys entering puberty. Understanding their nature will help you no longer worry. White pimples on the penis and pores, squeezing out with a white core. Do these acne affect fertility? This top concern in many young people will be answered right after.
harshitatyagi

What are some infertility treatments in Delhi, India? - 0 views

www.quora.com/...Geetanjali-Kapoor-31

infertility treatment IVF Treatment IUI Treatment ICSI Treatment Fertility Treatment

shared by harshitatyagi on 09 Nov 22 - No Cached
  • harshitatyagi on 09 Nov 22
     
    If you are struggling with infertility and have no idea what to do or how to resolve the biggest complications, then you need to take the essential step right now and acknowledge what the top infertility treatments as suggested by top fertility experts are: IVF, IUI & ICSI, for more details visit the link.
harshitatyagi

Is it moral/ethical to use assisted reproductive technologies (ART) such as in-vitro fe... - 0 views

www.quora.com/...Geetanjali-Kapoor-31

Infertility Treatment Fertility Treatment IVF Treatment Assisted Reproductive Technology

shared by harshitatyagi on 09 Nov 22 - No Cached
  • harshitatyagi on 09 Nov 22
     
    Yes, it is completely fine to opt In-vitro fertilization when suffering from infertility, It is the most popular method accepted all around the globe, and only due to this treatment method many couples have been able to become parents.
harshitatyagi

When should IVF be done? - 0 views

www.quora.com/...Geetanjali-Kapoor-31

IVF Treatment Infertility Treatment IVF Process Secondary Infertility In Vitro Fertilization

shared by harshitatyagi on 09 Nov 22 - No Cached
  • harshitatyagi on 09 Nov 22
     
    The most generic question that interrupts every couple's mind is when the IVF process should be done. Is it done when one fails to conceive, or is it done when one suffers from secondary infertility.
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