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In the first clinical proof of its kind, a drug has dramatically shrunk cancerous tumors by disrupting a key genetic pathway. But a study targeting one deadly brain cancer, medulloblastoma, ended in disappointment as the patient's once-tamed tumor quickly developed resistance to the drug and killed him.

"The Best Search Engine are your friends! Pathways is a collaborative project that targets anyone who uses digital technology, from students to professionals, from companies to universities."

"WikiPathways is an open, public platform dedicated to the curation of biological pathways by and for the scientific community. "

Droplet network printer ""We aren't trying to make materials that faithfully resemble tissues, but rather structures that can carry out the functions of tissues," said Professor Hagan Bayley of Oxford University's Department of Chemistry, who led the research. "We've shown that it is possible to create networks of tens of thousands of connected droplets. The droplets can be printed with protein pores to form pathways through the network that mimic nerves and are able to transmit electrical signals from one side of a network to the other.""

"Computer science (CS) education is a pathway to innovation, to creativity and to exciting career opportunities. We believe that all students deserve these opportunities. That is why Google is committed to developing programs, resources, tools and community partnerships which make CS engaging and accessible for all students."

Has a cheap and effective treatment for chronic pain been lying under clinicians' noses for decades? Researchers have found that a very high dose of an opiate drug that uses the same painkilling pathways as morphine can reset the nerve signals associated with continuous pain - at least in rats. If confirmed in humans, the procedure could reduce or eliminate the months or years that millions of patients spend on pain-managing prescription drugs. The results of the study are described today in Science1.

"The SOS-Ras-Raf-MAPK cascade plays a central role here. In about 25% of human tumors, Ras proteins are present in structurally altered forms that enable them to release a flux of mitogenic signals into cells, without ongoing stimulation by their normal upstream regulators (Medema and Bos 1993). We suspect that growth signaling pathways suffer deregulation in all"

Music, an abstract stimulus, can arouse feelings of euphoria and craving, similar to tangible rewards that involve the striatal dopaminergic system. Using the neurochemical specificity of [11C]raclopride positron emission tomography scanning, combined with psychophysiological measures of autonomic nervous system activity, we found endogenous dopamine release in the striatum at peak emotional arousal during music listening. To examine the time course of dopamine release, we used functional magnetic resonance imaging with the same stimuli and listeners, and found a functional dissociation: the caudate was more involved during the anticipation and the nucleus accumbens was more involved during the experience of peak emotional responses to music. These results indicate that intense pleasure in response to music can lead to dopamine release in the striatal system. Notably, the anticipation of an abstract reward can result in dopamine release in an anatomical pathway distinct from that associated with the peak pleasure itself. Our results help to explain why music is of such high value across all human societies.

Our intrepid reporter performs an intimate act in an fMRI scanner to explore the pathways of pleasure and pain

You can protect trees from the damage done by rodents and animals with fences. To protect trees from such rodents and pests, it is essential to install a fence (offered by Coastline Sediment Control) around every tree planted alongside roads and pathways.