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Theodore Berger and his team at the USC Viterbi School of Engineering's Department of Biomedical Engineering have developed a neural prosthesis for rats that is able to restore their ability to form long-term memories after they had been pharmacologically blocked. In a dramatic demonstration, Berger blocked the ability to rats to form long-term memories by using pharmacological agents to disrupt the neural circuitry that communicates between two subregions of the hippocampus, CA1 and CA3, which interact to create long-term memory, prior research has shown. The rats were unable to remember which lever to pull to gain a reward, or could only remember for 5-10 seconds, when previously they could remember for a long period of time. The researchers then developed an artificial hippocampal system that could duplicate the pattern of interaction between CA3-CA1 interactions. Long-term memory capability returned to the pharmacologically blocked rats when the team activated the electronic device programmed to duplicate the memory-encoding function. The researchers went on to show that if a prosthetic device and its associated electrodes were implanted in animals with a normal, functioning hippocampus, the device could actually strengthen the memory being generated internally in the brain and enhance the memory capability of normal rats. "These integrated experimental modeling studies show for the first time that with sufficient information about the neural coding of memories, a neural prosthesis capable of real-time identification and manipulation of the encoding process can restore and even enhance cognitive mnemonic processes," says the paper. Next steps, according to Berger and Deadwyler, will be attempts to duplicate the rat results in primates (monkeys), with the aim of eventually creating prostheses that might help human victims of Alzheimer's disease, stroke, or injury recover function. Ref.: "A Cortical Neural Prosthesis for Restoring and Enhancing

"There is a "significant credibility gap" between researchers' expectations and the likelihood of their forging long-term careers in higher education, a survey has found. More than three-quarters of research staff responding to the Careers in Research Online Survey 2013 said they aspired to a career in higher education and around two-thirds said they expected to achieve this. But it was "unrealistic to expect" that this number of research staff, or even half of those in the early stages of their career, would be able to secure a long-term research role in higher education, says the report, based on the survey produced by Vitae, the careers organisation for researchers."

ScienceDaily (Oct. 17, 2011) - Rising sea levels in the coming centuries is perhaps one of the most catastrophic consequences of rising temperatures. Massive economic costs, social consequences and forced migrations could result from global warming. But how frightening of times are we facing? Researchers from the Niels Bohr Institute are part of a team that has calculated the long-term outlook for rising sea levels in relation to the emission of greenhouse gases and pollution of the atmosphere using climate models.

As a subclass of agriculture, dairy farming is also a long-term enterprise that's producing milk and other dairy products. Farming a dairy involves heavy investment in terms of land, building, cows etc that's why supporting the movement of enterprising label the trivedi effect treated cows have shown an increase in milk production and reproduction too.

'The Exoplanet Exploration Program (ExEP) is responsible for implementing NASA's plans for the discovery and understanding of planetary systems around nearby stars. ExEP plays an important function in exoplanet research, by laying out a long-term view of the entire field and charting out a strategic timeline of missions and instruments."

Welcome to the future! Here you will find a speculative timeline of future history. Part fact and part fiction, the timeline is based on detailed research that includes analysis of current trends, projected long-term environmental changes, advances in technology such as Moore's Law, future medical breakthroughs, and the evolving geopolitical landscape. Where possible, references have been provided to support the predictions. FutureTimeline.net is intended to be an ongoing, collaborative project that is open for discussion - we welcome ideas from scientists, futurists, inventors, writers and anyone else interested in the future of our world.

ScienceDaily (Nov. 4, 2010) - Positive psychological changes that occur during meditation training are associated with greater telomerase activity, according to researchers at the University of California, Davis, and the University of California, San Francisco. The study is the first to link positive well-being to higher telomerase, an enzyme important for the long-term health of cells in the body.

A new study in The Lancet rates the harmfulness of 20 psychoactive drugs according to 16 criteria and finds that alcohol comes out on top. Although that conclusion is generating headlines, it is not at all surprising, since alcohol is, by several important measures (including acute toxicity, impairment of driving ability, and the long-term health effects of heavy use), the most dangerous widely used intoxicant, and its abuse is also associated with violence, family breakdown, and social estrangement. A group of British drug experts gathered by the Independent Scientific Committee on Drugs (ISCD) rated alcohol higher than most or all of the other drugs for health damage, mortality, impairment of mental functioning, accidental injury, economic cost, loss of relationships, and negative impact on community. Over all, alcohol rated 72 points on a 100-point scale, compared to 55 for heroin, 54 for crack cocaine, and 33 for methamphetamine. Cannabis got a middling score of 20, while MDMA (Ecstasy), LSD, and psilocybin mushrooms were at the low end, with ratings of 9, 7, and 6, respectively.

Free, research level articles in a variety of scientific fields. When one remembers that research journals often go for hundreds of dollars per year in hardcopy form, a resource like this is appreciated even more, in this time of widespread long term unemployment in the pure and applied sciences.

More than 6,000 different species living on the sea-floor have been identified so far and more than half of these are unique to the icy continent. A combination of long-term monitoring studies, newly gathered information on the marine life distribution and global ocean warming models, enable the scientists to identify Antarctica's marine "biodiversity hotspots". Researcher Griffiths describes how krill populations (the shrimp-like invertebrates eaten by penguins, whales and seals) are reducing as a result of a decrease in sea-ice cover. A much smaller crustacean (copepods) is dominating the area once occupied by them. This shifts the balance of the food web to favour predators, like jellyfish, that are not eaten by penguins and other Southern Ocean higher predators. Sea-ice reduction is also affecting penguins that breed on the ice.

ScienceDaily (Apr. 26, 2011) - In a paper published in the April 25 early online edition of the Proceedings of the National Academy of Sciences, researchers at the University of California, San Diego School of Medicine, the Gladstone Institutes in San Francisco and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing, primitive neural precursor cells from human embryonic stem cells (hESCs) that can be directed to become many types of neuron without increased risk of tumor formation.

Listen up, Facebook and Twitter groupies: how easily can social pressure affect your memory? Very easily, researchers at the Weizmann Institute and University College London have proved, and they think they even know what part of the brain is responsible. The participants conformed to the group on these "planted" responses, giving incorrect answers nearly 70% of the time. Volunteers watched a documentary film in small groups. Three days later, they returned to the lab individually to take a memory test, answering questions about the film. They were also asked how confident they were in their answers. They were later invited back to the lab to retake the test. This time, the subjects were also given supposed answers of the others in their film-viewing group (along with social-media-style photos) while being scanned in a functional MRI (fMRI) that revealed their brain activity. Is most of what you know false? Planted among these were false answers to questions the volunteers had previously answered correctly and confidently. The participants conformed to the group on these "planted" responses, giving incorrect answers nearly 70% of the time. To determine if their memory of the film had actually undergone a change, the researchers invited the subjects back to the lab later to take the memory test once again, telling them that the answers they had previously been fed were not those of their fellow film watchers, but random computer generations. Some of the responses reverted back to the original, correct ones, but get this: despite finding out the scientists messed with their minds, close to half of their responses remained erroneous, implying that the subjects were relying on false memories implanted in the earlier session. An analysis of the fMRI data showed a strong co-activation and connectivity between two brain areas: the hippocampus and the amygdala. Social reinforcement could act on the amygdala to persuade our brains to replace a strong memory wi

Scientists at the McEwen Centre for Regenerative Medicine and the Ontario Cancer Institute have isolated a human blood stem cell in its purest form: as a single stem cell capable of regenerating the entire blood system. "This discovery means we now have an increasingly detailed road map of the human blood development system, including the much sought after stem cell," says principal investigator John Dick, who holds a Canada Research Chair in Stem Cell Biology and is a Senior Scientist at the McEwen Centre for Regenerative Medicine and the Ontario Cancer Institute, University Health Network (UHN). "We have isolated a single cell that makes all arms of the blood system, which is key to maximizing the potential power of stem cells for use in more clinical applications. Stem cells are so rare that this is a little like finding a needle in a haystack," says Dr. Dick. Ref.: John E. Dick, Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment, Science, July 2011: Vol. 333 no. 6039 pp. 218-221 [DOI: 10.1126/science.1201219]

"Dairy farming is defined as a sub class of the agricultural enterprise involved in long-term production of milk which is processed for eventual use of manufacturing dairy products."

"Lunyr is an Ethereum-based decentralized crowdsourced encyclopedia which rewards users with app tokens for peer-reviewing and contributing information. We aim to be the starting point of the internet for finding reliable, accurate information. Our long-term vision is to develop a knowledge base API that developers can use to create next generation decentralized applications in Artificial Intelligence, Virtual Reality, Augmented Reality, and more."

"Our long-term goal is to democratize AI. We want to level the playing field for startups to ensure that innovation doesn't get locked up in large companies like Google or Facebook. If you're starting an AI company, we want to help you succeed. Apply here and mention this post in your application."

ACL Digital Life Sciences has a track record of partnering successfully with some of the leading Pharmaceuticals, Biotechs, CROs, Medical Devices and MSP companies. We offer multiple sourcing models to suit your business needs. We work with an MSP of your choice, insourcing staff augmentation, insourcing and outsourcing FSP models and Project-based deliverables. We do this to provide you with the flexibility you need - whether it's for onsite or remote resources, long term or project-specific resources, SME consultation, resources available across multiple geographic areas, resources mapping US time zones or working off-hours in local time zones, among other requirements.