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A 36-year-old man has received the world's first synthetic trachea, made from a synthetic scaffold seeded with his own stem cells, in an operation at the Karolinska University Hospital in Stockholm, Sweden. Professor Paolo Macchiarini of Karolinska University Hospital and Karolinska Institutet led an international team, including professor Alexander Seifalian from University College London, who designed and built the nanocomposite tracheal scaffold, and Harvard Bioscience, which produced a specifically designed bioreactor used to seed the scaffold with the patient´s own stem cells. The cells were grown on the scaffold inside the bioreactor for two days before transplantation to the patient. Because the cells used to regenerate the trachea were the patient's own, there has been no rejection of the transplant and the patient is not taking immunosuppressive drugs. "The big conceptual breakthrough is that we can move from transplanting organs to manufacturing them for patients," says David Green, the president of Harvard Bioscience in Holliston, Massachusetts. Transplantations of tissue-engineered windpipes with synthetic scaffolds in combination with the patient's own stem cells as a standard procedure means that patients will not have to wait for a suitable donor organ. Patients could benefit from earlier surgery and have a greater chance of cure. This would be of especially great value for children, since the availability of donor tracheas is much lower than for adult patients.

Scientists in central Germany are working on a method with which they reckon they could diagnose Alzheimer's disease years before any symptoms are noticed - by looking up patients' noses.

""We've developed the enabling technologies to create upper-extremity prosthetics that are more natural in appearance and use, a truly revolutionary advancement in prosthetics," said APL's Michael McLoughlin, the program manager. "Now, in Phase 3, we are ready to test it with humans to demonstrate that the system can be operated with a patient's thoughts and that it can provide that patient with sensory feedback, restoring the sensation of touch.""

In 1953, he underwent an experimental brain operation in Hartford to correct a seizure disorder, only to emerge from it fundamentally and irreparably changed. He developed a syndrome neurologists call profound amnesia. He had lost the ability to form new memories. For the next 55 years, each time he met a friend, each time he ate a meal, each time he walked in the woods, it was as if for the first time. And for those five decades, he was recognized as the most important patient in the history of brain science.

Apomediation is a new scholarly socio-technological term that characterizes the process of disintermediation (intermediaries are middlemen or "gatekeeper", e.g. health professionals giving "relevant" information to a patient, and disintermediation means to bypass them), whereby the former intermediaries are functionally replaced by apomediaries, i.e. network/group/collaborative filtering processes [Eysenbach, 2008 [WebCite] and 2007b]. The difference between an intermediary and an apomediary is that an intermediary stands "in between" (latin: inter- means "in between") the consumer and information/service, i.e. is absolutely necessary to get a specific information/service. In contrast, apomediation means that there are agents (people, tools) which "stand by" (latin: apo- means separate, detached, away from) to guide a consumer to high quality information/services/experiences, without being a prerequisite to obtain that information/service in the first place. The switch from an intermediation model to an apomediation model has broadimplications for example for the way people judge credibility, as hypothesized and elaborated in more detail elsewhere [

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