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In 1953, he underwent an experimental brain operation in Hartford to correct a seizure disorder, only to emerge from it fundamentally and irreparably changed. He developed a syndrome neurologists call profound amnesia. He had lost the ability to form new memories. For the next 55 years, each time he met a friend, each time he ate a meal, each time he walked in the woods, it was as if for the first time. And for those five decades, he was recognized as the most important patient in the history of brain science.

How do we relate human thought processes to measurable events in the brain? Mental chronometry, which has origins that date back more than a century, seeks to measure the time course of mental operations in the human nervous system [1]. From the late 1800s until 1950, the field was built almost entirely around a single method: measuring and comparing people's reaction times during simple cognitive tasks.