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Paige Prescott

Synthetic DNA Created, Evolves on Its Own - 1 views

news.nationalgeographic.com/...volution-genetics-life-science

synthetic dna

shared by Paige Prescott on 20 Apr 12 - No Cached
  • Paige Prescott on 20 Apr 12
     
    a new nucleic acid to learn about- XNA!
Paige Prescott

deCODEme - Empowering prevention. Calculate genetic risk for diseases, DNA research for... - 0 views

www.decodeme.com

genetics DNA testing technology

shared by Paige Prescott on 25 Mar 12 - Cached
  • Paige Prescott on 25 Mar 12
     
    a company that sells DNA technology and genetic screening.
Changul Louis Yeum

Study Says DNA's Power to Predict Illness Is Limited - 0 views

www.nytimes.com/...ct-is-limited-study-finds.html

DNA disease research gene

shared by Changul Louis Yeum on 11 Apr 12 - No Cached
  • Changul Louis Yeum on 11 Apr 12
     
    The answer, according to a new study of twins, is, for the most part, "no." While sequencing the entire DNA of individuals is proving fantastically useful in understanding diseases and finding new treatments, it is not a method that will, for the most part, predict a person's medical future.
Kaoko Miyazaki

The Rinn Lab - 0 views

www.rinnlab.com/research.html

RNA

shared by Kaoko Miyazaki on 11 Apr 12 - No Cached
  • Kaoko Miyazaki on 11 Apr 12
     
    John Rinn (RNA researcher at Harvard Medical School) continues on his ongoing research about Long Intergenic Noncoding RNA's (lincRNAs). lincRNAs used to be overlooked and classified as 'waste' products, but today it is seen as the contractors that create the DNA's coding sequence needed for the organism's structure. In simpler terms, lincRNAs are responsible for putting molecular materials in places they are supposed to be - as though following a rough draft to make a final master piece. Because lincRNAs have so many functions, if step goes wrong, it could cause potential harm to the organism such as creating a tumor. But because of their many functions like guiding the interactions of protein DNA to name one, John Rinn and other current scientists hypothesize that lincRNAs are what differentiates us from other organisms and makes us, us.
avikan

New Hope Of a Cure For H.I.V. - NYTimes.com - 0 views

query.nytimes.com/...fullpage.html

shared by avikan on 11 Apr 12 - No Cached
  • So people with H.I.V. now must take drugs every day for life, which some researchers say is not a sustainable solution for tens of millions of infected people.
  • CCR5,
  • This is what was done with the Trenton patient. Some of the man's white blood cells were removed from his body and treated with a gene therapy developed by Sangamo BioSciences. The therapy induced the cells to produce proteins called zinc-finger nucleases that can disrupt the CCR5 gene.
  • ...5 more annotations...
    • avikan
      avikan on 11 Apr 12
       
      Millions of people worldwide are currently affected by HIV and many have died from AIDS. Scientists have been trying for many years to find a cure for the epidemic, but now many are trying to find a way to prevent the passing on of the virus for future generations. Although no definite treatment has been discovered yet, recent findings have shown promising results for the future. 
    • avikan
      avikan on 11 Apr 12
       
      With the fast developing biological technologies we are seeing today, scientists hope's are growing stronger.  Maybe one of us one day will be a part of the phenomenon, in search of a way to help the millions affected by the epidemic  
    • avikan
      avikan on 11 Apr 12
       
      CD4 cells initiate the body's response to infections.
    • avikan
      avikan on 11 Apr 12
       
      Many forms of HIV, initially use CCR5 to enter and infect host cells. A few individuals carry a mutation known as CCR5 delta 32 in the CCR5 gene, protecting them against these strains of HIV.
    • avikan
      avikan on 11 Apr 12
       
      For over 30 years scientists have been trying to find a cure for the HIV/AIDs epidemic and so far have been unsuccessful 
    • avikan
      avikan on 11 Apr 12
       
      Incase some of us forgot, AIDs stands for Acquired immune deficiency syndrome, a disease in which there is a severe loss of the body's cellular immunity. And HIV stands for Human immunodeficiency virus, a virus that causes AIDs
Sea Maskulrath

Anti-cloning advocate Fred Sauer files to run for governor - 0 views

www.stltoday.com/...6b-11e1-8534-0019bb30f31a.html

anti cloning

shared by Sea Maskulrath on 09 Apr 12 - No Cached
  • Anti-cloning advocate Fred Sauer files to run for governor
  • . LOUIS • Anti-cloning activist Fred Sauer may be looking to convert his legal victory into a political win.
  • Although Sauer is no stranger to generating publicity for his causes, he added his name to the Republican contenders for governor with little fanfare Monday morning.
  • ...1 more annotation...
  • This year, however, Sauer won a round in court, convincing a judge to rule against Gov. Jay Nixon's signature bio-tech initiative, MOSIRA, which seeks to help tech start-ups in the state.
  • Sea Maskulrath on 09 Apr 12
     
    As with all the processing happening around the world there are also people with money and power that are also trying to prevent cloning form happening. 
Sea Maskulrath

Scientists clone pashmina goat - Hindustan Times - 0 views

www.hindustantimes.com/...Article1-825339.aspx

clone goat

shared by Sea Maskulrath on 09 Apr 12 - No Cached
  • three years of producing the first-ever buffalo animal clone, Indian scientists have now successfully cloned the world's first pashmi
  • The cloned baby is kept under medical observation at the off campus sheep breeding centre and is in "fine health"
  • The cloned was produced with the help of a cost-effective "hand guided t
  • ...1 more annotation...
  • echnique" and NDRI had used the same technology to clone two buffalo calves on its Karnal campus.
  • Sea Maskulrath on 09 Apr 12
     
    Now that the cost of the pashmina will be lowered, we have to thank Dr.Tej for his hard work and that we cannot underestimate indian biotechnology.   
Sea Maskulrath

Boffins set mammoth cloning task - 0 views

www.heraldsun.com.au/...story-fn5iztw3-1226298850815

gene cloning

shared by Sea Maskulrath on 09 Apr 12 - No Cached
  • Sea Maskulrath on 09 Apr 12
     
    As it has been stated in the news, Russia and south Korean scientist has been working together in this cloning project in order to compress the gene of mammoth into an embryo ,which then will be placed into the womb of an indian elephant. if successful, they will be able to recreate the mammoth :) WOW
pet-chompoo sa-ngarmangkang

Heart Failure Gene Discovered...In the Kidney - St. Louis News - Daily RFT - 0 views

blogs.riverfronttimes.com/...ure_gene_prevention_kidney.php

shared by pet-chompoo sa-ngarmangkang on 07 Apr 12 - No Cached
  • risk for heart failure
  • e high blood pressure
  • t's related to the kidney.
  • ...8 more annotations...
  • "It also makes hormones involved in maintaining blood volume."
  • So they began sequencing the kidney gene, looking for problems.
  • "The CLCNKA polymorphism decreases the kidney's functionality by about half,"
  • gene remains silent with no effect on the body until there's an injury to the heart
  • the blood flow to the kidney decreases and the kidney secretes the hormones angiotensin and aldosterone which lead to a high risk of heart failure."
  • More blood with less space to move leads to high blood pressure
  • puts more pressure on the heart.
  • presence of the gene drives the risk of heart failure from 20 percent to 27 percent for people with one copy and 54 percent for people with two
pet-chompoo sa-ngarmangkang

Craving Coffee? It Might Be in Your Genes - Slashfood - 0 views

www.slashfood.com/...ffee-it-might-be-in-your-genes

shared by pet-chompoo sa-ngarmangkang on 07 Apr 12 - No Cached
  • 3 o'clock caffeine craving can also be traced back to your gene
  • depending on whether you carry a "high-consumption" variant or "low-consumption" variant of either gene determines just how fast or slow you metabolize caffeine
  • genetics plays a big role in a lot of behaviors, such as smoking and alcohol consumption
  • ...2 more annotations...
  • how much caffeine we drink."
  • CYP1A2 and AHR,
pet-chompoo sa-ngarmangkang

BBC News - 'Tipsy' alcohol gene 'could help curb alcoholism' - 0 views

www.bbc.co.uk/...health-11572894

shared by pet-chompoo sa-ngarmangkang on 07 Apr 12 - No Cached
  • people who react strongly to alcohol are less likely to become addicted
  • the gene we have found tells us a lot about how alcohol affects the brain
  • Most of the alcohol people consume is broken down in the liver, but some is metabolised in the brain by an enzyme which the CYP2E1 gene
  • ...2 more annotations...
  • "tipsy" version of CYP2E1 break down alcohol more readily, which explains why they feel the effects of alcohol much quicker than others
  • CYP2E1 on chromosome 10 appears to dictate whether a person can hold their drink better than others.
Kantham Hongdusit

Key enzyme involved in protecting nerves from degeneration identified - 0 views

www.sciencedaily.com/...120330164852.htm

enzyme protecting key genetics

shared by Kantham Hongdusit on 02 Apr 12 - No Cached
  • Kantham Hongdusit on 02 Apr 12
     
    Fly's enzyme is used to cure diseases such as Parkinson's, and aid nerve damage and spinal cord
Pop karnchanapimonkul

Study Identifies Genetic Regulators Hijacked By Avian And Swine Flu Viruses - 0 views

www.medicalnewstoday.com/...243562.php

study swine flu viruses

shared by Pop karnchanapimonkul on 02 Apr 12 - No Cached
  • Pop karnchanapimonkul on 02 Apr 12
     
    Genes and Swine Flu
Nitchakan Chaiprukmalakan

Plant research reveals new role for gene silencing protein - 0 views

www.sciencedaily.com/...120329141923.htm

shared by Nitchakan Chaiprukmalakan on 02 Apr 12 - No Cached
    • wasin kusakabe
      wasin kusakabe on 02 Apr 12
       
      Termination is equally as important as other sections of Transcription
  • Termination is the final stage of transcription.
  • Without termination, transcription continues down the chromosome unchecked.
  • ...3 more annotations...
  • The expression of a gene, when an organism's DNA is transcribed into a useable product, requires activation via a promoter or an external trigger.
  • DCL4 is a back-up to termination processes, helping a gene to be successfully expressed
  • If a gene ends badly, aberrant RNA will trigger silencing pathways
  • Sea Maskulrath on 02 Apr 12
     
    this new way to making the mature mRNA is very interesting. gotta love it. 
orasa sukmark

Gene therapy - 0 views

www.sciencedaily.com/...gene_therapy.htm

gene therapy

shared by orasa sukmark on 02 Apr 12 - No Cached
  • orasa sukmark on 02 Apr 12
     
    general info on gene therapy
Sasicha Manupipatpong

Divergent evolution illuminated: Light shed on reasons behind genome differences betwee... - 0 views

www.sciencedaily.com/...120329124607.htm

trna dna evolution genome differences proteins biotechnology

shared by Sasicha Manupipatpong on 01 Apr 12 - No Cached
  • divergent evolution of the genomes of different groups of species
  • three large domains: Archaea, Bacteria and Eukarya
  • genomes of each group have evolved towards distinct structures that have favored their separation
  • ...15 more annotations...
  • connection between the function of enzymes and the composition of the genomes shed light on the evolution and structure of genes
  • analyzed the distribution and abundance of transfer RNA genes
  • structure of genomes was adapted to the activity of some enzymes, which differ for Bacteria and for Eukarya and are absent in Archaea
  • activity of these enzymes modifies tRNAs, allowing them to recognize up to three distinct codons
    • Sasicha Manupipatpong
      Sasicha Manupipatpong on 01 Apr 12
       
      Prior to the study, it was understood that tRNA's have a specific anti-codon sequence which would recognize a single mRNA codon with the complementary sequence. Does this mean that the tRNA also attaches to different amino acids as well? How does the tRNA differentiate between the different amino acids it is at that moment carrying and the codon it matches with on the mRNA--does it change shape according to which amino acid is attached to it?
  • activity of the bacterial and eukaryal enzymes is different, which explains why the genomes and the gene composition of bacteria, eukarya, and archaea have diverged
  • relation between genome structure and the speed of protein synthesis from its genes
  • demonstrates how organisms have evolved in a different manner to achieve better adaptations and to have optimum protein translation efficiency
  • biotechnology as the discovery of the relevance of these modifications will allow an improvement in the industrial production of proteins
  • another parameter with which to optimize the synthesis of proteins from a gene
  • human insulin is "manufactured" in bacteria and our discovery would allow this production to be increased if we take into account the activity of these enzymes
  • relevant for the study of cancer: "it is possible that these modification enzymes are over-represented in some kinds of cancer. In fact, this would be logical because cancer cells are highly efficient in producing proteins."
  • greater the abundance of a protein in a cell the higher the number of triplets found in its gene sequence that can be read by modified tRNAs
  • don't exactly know why these enzymes appear or why they are different in bacteria and in eukaryotes but it's clear that they contribute to the separation of genomes of these two groups
  • genetic code is the same
  • what has changed is the relative importance of different codons of the code
  • Sasicha Manupipatpong on 01 Apr 12
     
    A recent study uncovers the reasons for the divergent evolution of the genomes of different species. The findings provide information about tRNA modifications which may prove useful in the field of biotechnology, specifically in the industrial production of proteins
Kaoko Miyazaki

Genetics as Rorschachs: Pondering Our Genes and Our Fate | Psychology Today - 0 views

www.psychologytoday.com/...ndering-our-genes-and-our-fate

genetics disease

shared by Kaoko Miyazaki on 01 Apr 12 - No Cached
  • Kaoko Miyazaki on 01 Apr 12
     
    Even today scientists find the study of genes an ambiguous topic. The randomness of the genes being passed down or not, whether one child has a mutations while the other does not or if your sister has a higher risk of getting breast cancer than you is still being tested.
orasa sukmark

Junk DNA Can Revive and Cause Disease, Study Finds - NYTimes.com - 0 views

www.nytimes.com/...20gene.html

shared by orasa sukmark on 30 Mar 12 - No Cached
  • can rise from the dead like zombies
  • dead gene come back to life and cause a disease
  • Some of those genes, surprised geneticists reported Thursday, can rise from the dead like zombies, waking up to cause one of the most common forms of muscular dystrophy.
    • adisa narula
      adisa narula on 30 Mar 12
       
      Do these genes revive automatically?
  • ...16 more annotations...
  • a dead gene come back to life and cause a disease.
  • FSHD affects about 1 in 20,000 people
  • people who have the disease cannot smile.
  • It is a dominant genetic disease.
  • function, if any, is largely unknown.
  • function, if any, is largely unknown
  • FSHD, is one of the most common forms of muscular dystrophy.
  • in a way FSHD was the easy case — it is a disease that affects every single person who inherits the genetic defect. Other diseases are more subtle, affecting some people more than others, causing a range of symptoms.
  • The dead gene was also repeated on chromosome 10, but that area of repeats seemed innocuous, unrelated to the disease. Only chromosome 4 was a problem.
  • chromosome 4 was a problem.
  • No one whose dead gene was repeated more than 10 times ever got FSHD
  • it was not completely inactive. It is always transcribed
  • copied by the cell as a first step to making a protein.
  • But the transcriptions were faulty, disintegrating right away. They were missing a crucial section, called a poly (A) sequence, needed to stabilize them.
  • But the transcriptions were faulty, disintegrating right away. They were missing a crucial section, called a poly (A) sequence, needed to stabilize them.
  • extra copies change the chromosome’s structure, shutting off the whole region so it cannot be used.
Kaoko Miyazaki

lincRNA: A recently discovered RNA organizes stem cell differentiation - 0 views

scitechstory.com/...izes-stem-cell-differentiation

RNA lincRNA

shared by Kaoko Miyazaki on 11 Apr 12 - No Cached
  • Kaoko Miyazaki on 11 Apr 12
     
    Organizing how proteins assemble in embryonic cells and taking control over/deciding whether a stem cells stays pluripotent or not are only two of the main functions of the recently discovered lincRNAs. These new discoveries of lincRNAs and ongoing experiments only help researches such as Mitchell Guttman from the Broad Institute widen up the study of genetics and the human genome to a new field.
adisa narula

Breaking the Silence: The Rise of Epigenetic Therapy - 0 views

jnci.oxfordjournals.org/...874.full

cancer DNA genetics research epigenetic

shared by adisa narula on 12 Apr 12 - No Cached
  • adisa narula on 12 Apr 12
     
    Cancer epigenetics is hot. At the annual meeting of the American Association for Cancer Research in April, once-obscure principal investigators were feted by gaggles of admirers and many poster presenters mobbed by the curious. "It's one of the hottest areas of basic biology," said Paul Workman, Ph.D., director of cancer therapeutics at Cancer Research U.K.
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