Skip to main content

Home/ Groups/ PHE - Resources
Dennis OConnor

Precision Health: Know More About Your Body, Worry Less | Q Bio - 1 views

  •  
    In 2008 Jeff Kaditz was rushed to the hospital after being hit by a car. He spent months in a hospital bed and had to learn to walk again. He was misdiagnosed twice before finding out he needed major surgery. Throughout the process he was frustrated by the lack of quantitative information that was available about his body, which led to a wide range of inconsistent diagnoses. Jeff imagined a day when everything about a person's body could be quickly measured, shared and analyzed. He started researching a solution and in 2015 he met Dr. Michael Snyder and Dr. Garry Choy. They immediately bonded over a shared vision that became Q.
Dennis OConnor

Milli | Artificial Intelligence Powered Health Coach - 0 views

  •  
    "Meet Milli A self-teaching personalized medical intelligence platform built from real-time analysis of millions of patient/doctor interactions. The Medical Intelligence Platform™ makes it easy to capture, aggregate, and analyze comprehensive patient data with human-augmented Artificial Intelligence. We provide doctors with suggestions for the likely underlying dysfunctions that lead to disease, recommendations for follow up tests, and predictions for which intervention will be most effective for each patient. Our Virtual Health Assistant then provides intervention support to the patient and tracks their adherence and medical outcomes. This closed-loop process enables the platform to systematically learn from every provider/patient medical encounter to learn how to better prevent and reverse disease."
Dennis OConnor

INGH Institute for Next Generation Healthcare - 0 views

  • We offer an inspirational ecosystem for healthcare professionals, patients, scientists and entrepreneurs determined to close the gap between health and care at a time when the failures of the current healthcare system call for an innovation movement to bring transformational change.
  • All our innovations will have the human experience at heart
  • The Institute for Next Generation Healthcare at Mount Sinai launched an ambitious project called LymeMIND
  •  
    DeAunne Denmark, MD, PhD - OUR CORE PREMISE: To improve health, we must close the gap between what we know and what we do. "INGH has a new facility and venture that is the best I've seen anywhere to get a whole slew of high-resolution data collected in one shot. And supposedly, it is "not that expensive"...
Dennis OConnor

Mt. Sinai Lab100 - 0 views

  •  
    Part clinic, part research lab, Lab100 uses precision diagnostics to empower patients and help scientists advance our understanding of human health.
Dennis OConnor

End of Life Liberty: Empowering Dying Patients with Choices. - 0 views

  •  
    "Biomedical Ethics Seminar Series: Special Event  End of Life Liberty: Empowering Dying Patients with Choices. An overview of the evolving changes in law and medicine governing patient autonomy at the end of life over the past 2 decades. What has been learned? What changes ought be considered? Can we move to normalize the practice of aid in dying within the practice of medicine? Do some states offer a model for practice governed by standard of care? Do psychedelic medicines offer a new palliative tool for patients with anxiety? What is the status of the research, and federal, state and local law governing psychedelic substances.
Dennis OConnor

What Went Wrong with Coronavirus Testing in the U.S. | The New Yorker - 0 views

  • n February 5th, sixteen days after a Seattle resident who had visited relatives in Wuhan, China, was diagnosed as having the first confirmed case of COVID-19 in the United States, the Centers for Disease Control, in Atlanta, began sending diagnostic tests to a network of about a hundred state, city, and county public-health laboratories⁠. Up to that point, all testing for COVID-19 in the U.S. had been done at the C.D.C.; of some five hundred suspected cases⁠ tested at the Centers, twelve had confirmed positive. The new test kits would allow about fifty thousand patients to be tested, and they would also make testing much faster, as patient specimens would no longer have to be sent to Atlanta to be evaluated.
  • Before a state or local lab could use the C.D.C.-developed tests on actual patients
  • verification
  • ...33 more annotations...
  • larger number, about thirty-six of them, received inconclusive⁠ results from one of the reagents.
  • Another five,
  • had problems with two reagents
  • On February 8th
  • e cascading effects that they’ve had on the country’s COVID-19 preparations suggest a much larger problem with the way the United States has structured its pandemic response.
  • the verification problems were “part of the normal procedures⁠.” In the meantime, she said, until new reagents could be manufactured, all COVID-19 testing in the United States would continue to take place exclusively at the C.D.C⁠.
  • The public-health-laboratory network was never intended to provide widespread testing in the event of a pandemic.
  • the three-week delay caused by the C.D.C.’s failure to get working test kits into the hands of the public-health labs came at a crucial time.
  • The void created by the C.D.C.’s faulty tests made it impossible for public-health authorities to get an accurate picture of how far and how fast the disease was spreadin
  • In hotspots like Seattle, and probably elsewhere, COVID-19 spread undetected for several weeks, which in turn only multiplied the need for more tests.
  • The problem was that containment was not done very well.
  • we’re looking at exponential growth, and we need to figure out how to meet an exponential demand.”
  • Yet flexibility was not what Jerome and his lab found when they tried to get an E.U.A. for their COVID-19 test.
  • problem was exacerbated by a President who has simultaneously underplayed the severity of the outbreak and overpromised the means available to fight it
  • problems with COVID-19 testing in the United States have obscured
  • several labs reported their problems to the C.D.C. In a briefing a few days later,
  • Chinese scientists uploaded a copy of the virus’s genome to an online repository⁠, and virologists around the world set to work to develop diagnostic tests for the new disease
  • January 21st, a team in Berlin, led by Christian Drosten, one of the scientists who discovered the original SARS virus, in 2003, submitted the first paper to describe a protocol for testing for SARS-CoV-2.
  • That protocol would form the basis for a test disseminated, early on, by the World Health Organization
  • That same day, Messonnier announced that the C.D.C. had finalized its own test⁠, which it used to confirm the first known case of COVID-19 in the U.S.
  • The U.W. virology lab
  • started, probably in earnest in mid-January, to prepare what we call a laboratory-developed test,⁠
  • It took a team at the lab, working under the direction of Alex Greninger, about two weeks to develop a working version
  • But, as soon as Alex Azar, the Secretary of Health and Human Services, declared a public-health emergency, on February 4th, a new regulatory regime took effect. From that point on, any lab that wanted to conduct its own tests for the new coronavirus would first need to secure something called an Emergency Use Authorization from the F.D.A.
  • This shift in the regulations sounds perverse, since it restricts the use of new tests at precisely the moment they’re most needed.
  • E.U.A. process is supremely flexible.
  • triumph of modern medical science
  • hen there’s a big emergency and we feel like we should really do something, it gets hard. It’s a little frustrating. We’ve got a lot of scientists and doctors and laboratory personnel who are incredibly good at making assays. What we’re not so good at is figuring out all the forms and working with the bureaucracy of the federal government.”
  • At one point, he was very frustrated because he’d e-mailed them what we were doing so they could review it,”
  • Here we are in this SARS-CoV-2 crisis, and you have to send them something through the United States Postal Service. It’s just shocking.
  • Despite these difficulties, Jerome said, the F.D.A. ultimately proved responsive to the lab’s entreaties. “They had good and substantive feedback that made our testing better, and the response time was typically just a couple of days.”
  • believe it was, February 29th,” he said. “And then we got a specimen from one of the people who were the two original cases in Washington
  • The E.U.A. regulations, however, prohibited the lab from reporting the results to the doctors who had ordered the tests for their patients.
  •  
    "Sharfstein, too, thinks that it's fair to criticize the federal government for not recognizing that its pandemic plans had a single point of failure. The C.D.C. quickly developed a working test, and it was understandable, at some level, that people at the Centers thought that fixing the faulty reagents for the public-health labs would be faster than shifting to an entirely different protocol. Nevertheless, Sharfstein said, "Why are we relying only on the C.D.C.? What the F.D.A. could have done, and eventually did do, is say, 'You can use other approaches.' " Even so, he said, "I don't think it's quite fair to totally blame the F.D.A. for this. The F.D.A. can design an approach to support the public-health strategy, but someone has to tell F.D.A. the public-health goal." The delay in clearly establishing those goals, he said, shows why the decision to shut down the N.S.C. directorate was so consequential. "People talk about, like, why does it matter that they closed the White House office on pandemic preparedness? This is one reason.""
Dennis OConnor

San Diego Community News Group - La Jolla doctor donates late father s tissue to help L... - 0 views

  •  
    "Before now, La Jolla biochemist Dr. Sharon Wampler never spoke publicly about the controversy that plagued her father's battle with Lyme Disease. Sharon's father, Whitfield (W.E.) Wampler, was age 92 when he passed away August of 2016. While it's unknown exactly how long W.E. lived with Lyme, his more severe symptoms-including joint failure and loss of hearing and eyesight-spanned over ten years."
Dennis OConnor

The Lyme Disease Biobank - Characterization of 550 Patient and Control Samples from the... - 0 views

  •  
    Recommended by Sharon Wampler "ABSTRACT Lyme disease (LD) is an increasing public health problem. Current laboratory testing is insensitive in early infection, the stage at which appropriate treatment is most effective in preventing disease sequela. The Lyme Disease Biobank (LDB) collects samples from individuals with symptoms consistent with early LD presenting with or without erythema migrans (EM) or an annular, expanding skin lesion, and uninfected individuals from endemic areas. Samples were collected from 550 participants (298 cases and 252 controls) according to IRB-approved protocols and shipped to a centralized biorepository. Testing was performed to confirm the presence of tick-borne pathogens by real-time PCR, and a subset of samples was tested for Borrelia burgdorferi by culture. Serology using the CDC's standard two-tiered testing algorithm (STTTA) for LD was performed on all samples. LD diagnosis was supported by laboratory testing in 82 cases, including positive STTTA, PCR, culture, or 2 positive ELISA's with EM >5 cm, while the remaining 216 cases had negative laboratory testing results. For the controls, 43 were positive on at least one of the tiers, and 6 were positive by STTTA. This collection highlights and reinforces the known limitations of serologic testing in early LD, with only 29% of individuals presenting with EM >5 cm yielding a positive result using the STTTA. Aliquots of whole blood, serum, and urine from clinically characterized patients with and without LD are available to investigators in academia and industry for evaluation or development of novel diagnostic assays for LD, to continue to improve upon currently available methods."
Dennis OConnor

Tipping Point: The Resistance Is Gaining In The Lyme Wars - 0 views

  •  
    Recommended by Sharon Wampler "For two decades, Lyme disease has had dueling identities.   A burgeoning epidemic wrought by ticks. A raging controversy over why patients stay sick - and what to do for them.   Now, however, the medical model that spawned the Lyme Wars - enshrined in treatment guidelines that say short-course antibiotics are curative - is yielding to a more nuanced picture.    This new image is of a disease that outwits antibiotics and immune systems; is plagued by diagnostic failures, and is capable of inflicting lasting damage. It is an image that challenges the picture of medical certainty that has long been Lyme."
Dennis OConnor

Vision - Human Vaccines Project - 0 views

  •  
    Recommended by DeAunne "For the first time ever, scientists at the Human Vaccines Project are combining systems biology with artificial intelligence to understand one of the greatest remaining frontiers of human health, the human immune system. Modeled after the transformative Human Genome Project, the Human Vaccines Project is leveraging cutting-edge technologies to decode the human immune system. Our scientists are working to unlock new preventions, diagnostics, and treatments for some of the world's most devastating diseases."
Dennis OConnor

FlowState Technology - Sana Health - 0 views

  •  
    Recommended by Deaunne - "A 25 YEAR JOURNEY BEGINS In 1992, the jeep Richard Hanbury was driving was forced to crash off a bridge in Yemen. He was pronounced clinically dead for 8 minutes and then in a coma for 6 weeks. After waking up, he spent the next 14 months in the hospital.  The doctors gave Richard five years to live due to the extreme chronic nerve damage pain. After a lightbulb moment while watching a film in hospital, he began the journey to save his life. To produce the most lasting pain relief, he experimented with the different neuromodulation patterns and bio-metric sensors which normalized how his brain processed pain signals. Since 1993, Richard Hanbury has been pain-free and has tested his technology with the British Special Air Service, U.S. Air Force, Richard Branson Virgin Challenger flights, and the first Solar Impulse flight around the world."
Dennis OConnor

MIT AgeLab Caregiver Study - 0 views

  •  
    A large portion of the population is involved in providing unpaid care for a family member. However, not much is known about what caregivers are doing on a daily basis, what services and resources they use, and how they balance caregiving with work and personal life. Researchers at the MIT AgeLab has conducted an exploratory study to learn more about caregivers and the caregiving experience. The research process and results are presented in this website.
Dennis OConnor

About IDEO's Open Innovation Practice - OpenIDEO - 0 views

  •  
    "We Design for Good Design thinking is in our genes. For decades, IDEO has pioneered the human-centered design approach to solving complex problems.  In 2010, IDEO asked-how might we open up our method, enabling people everywhere to spark innovation where it's needed most? Our answer: OpenIDEO."
Dennis OConnor

MS RD Victoria Anne Newman Obituary: View MS Newman's Obituary by San Diego Union-Tribune - 0 views

  •  
    " A memorial service is scheduled for 3:00 p.m. on March 15 at Beyster Auditorium on the UCSD campus. "
Dennis OConnor

10 medical research trends we'll be watching in 2020 and beyond | LinkedIn - 0 views

  • 1.   Making patients the priority
  • 2.   Listening and learning from patients
  • 3.   Increased focus on long-term commitments (rather than short-term wins
  • ...7 more annotations...
  • 4.   More inclusive medical research
  • 5.   More health data in the cloud
  • 7.   Greater focus on preventing disease, rather than treating it
  • 6.   A (much) bigger role for AI
  • 8.   More mysteries of the brain unlocked
  • 9.   Patient registries will continue aiding scientific discovery
  • 10. Continued optimism about the future
Dennis OConnor

Please support Project Apollo Team as they "Ride Out Lyme to raise funds for Lyme research - 0 views

  •  
    A message from Sharon: Please support Project Apollo Team as they "Ride Out Lyme to raise funds for Lyme research & to support patients! The 2nd annual event, we raised $10,000 last year. The money is split between BAL to support research and ROL for grants to patients over the age of 26 with financial need. We hope to earmark money raised by ROL La Jolla for San Diego patients in 2021, but this year the money is open to anyone in the US. The mission of Bay Area Lyme "to make Lyme disease easy to diagnose and simple to cure" and we plan to submit a "Measured Lyme" research proposal from Project Apollo in the coming year. Sharon, Mike and Meg will ride as part of the Project Apollo team. Others are welcome! We would love your support as a rider or with donations! To donate to Team Project Apollo visit https://rideoutlyme.salsalabs.org/lajolla2020/t/projectapollo/index.html Let's empower people to realize optimal health!
Dennis OConnor

Story & AIHM - Is Your Story Making You Sick? - 0 views

  •  
    "Is Your Story Making You Sick? has screened at top conferences and mental health organizations across the country-catalyzing important conversations about this innovative and effective approach to healing. From addiction treatment to trauma-informed communities - leading healthcare organizations and beyond - many have found our film to be a powerful tool to share a message of recovery, healing, and hope."
Dennis OConnor

Katie Teague on Vimeo - 0 views

  •  
    "Katie Teague is an independent documentary filmmaker and multi-media mystic working in the realm of transformational storytelling."
Dennis OConnor

The proximal origin of SARS-CoV-2 | Nature Medicine - 1 views

  • Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data
  • Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.
  • The receptor-binding domain (RBD) in the spike protein is the most variable part of the coronavirus genome1,2. Six RBD amino acids have been shown to be critical for binding to ACE2 receptors and for determining the host range of SARS-CoV-like viruses7.
  • ...18 more annotations...
  • Theories of SARS-CoV-2 originsIt is improbable that SARS-CoV-2 emerged through laboratory manipulation of a related SARS-CoV-like coronavirus.
  • the genetic data irrefutably show that SARS-CoV-2 is not derived from any previously used virus backbone
  • we propose two scenarios that can plausibly explain the origin of SARS-CoV-2: (i) natural selection in an animal host before zoonotic transfer; and (ii) natural selection in humans following zoonotic transfer.
  • COVID-19 were linked to the Huanan market in Wuhan
  • it is likely that bats serve as reservoir hosts for its progenitor
  • Malayan pangolins (Manis javanica) illegally imported into Guangdong province contain coronaviruses similar to SARS-CoV-221
  • Although no animal coronavirus has been identified that is sufficiently similar to have served as the direct progenitor of SARS-CoV-2, the diversity of coronaviruses in bats and other species is massively undersampled
  • Detailed understanding of how an animal virus jumped species boundaries to infect humans so productively will help in the prevention of future zoonotic events.
  • It is possible that a progenitor of SARS-CoV-2 jumped into humans, acquiring the genomic features described above through adaptation during undetected human-to-human transmission.
  • All SARS-CoV-2 genomes sequenced so
  • are thus derived from a common ancestor that had them too
  • Estimates of the timing of the most recent common ancestor of SARS-CoV-2 made with current sequence data point to emergence of the virus in late November 2019 to early December 201923,
  • compatible with the earliest retrospectively confirmed cases
  • Basic research involving passage of bat SARS-CoV-like coronaviruses in cell culture and/or animal models has been ongoing for many years in biosafety level 2 laboratories across the world27, and there are documented instances of laboratory escapes of SARS-CoV28. We must therefore examine the possibility of an inadvertent laboratory release of SARS-CoV-2.
  • The finding of SARS-CoV-like coronaviruses from pangolins with nearly identical RBDs, however, provides a much stronger and more parsimonious explanation of how SARS-CoV-2 acquired these via recombination or mutation1
  • it is reasonable to wonder why the origins of the pandemic matter
  • For a precursor virus to acquire both the polybasic cleavage site and mutations in the spike protein suitable for binding to human ACE2, an animal host would probably have to have a high population density (to allow natural selection to proceed efficiently) and an ACE2-encoding gene that is similar to the human ortholog
  • More scientific data could swing the balance of evidence to favor one hypothesis over another.
Dennis OConnor

Eric Topol M.D. (@EricTopol) / Twitter - 2 views

  •  
    Recommended by DeAunne Denmark, MD, PhD. Eric Topol's professional background: Gary & Mary West Endowed Chair of Innovative Medicine, Scripps Research Executive VP, Scripps Research Professor, Molecular Medicine, Scripps Research Director & Founder, Scripps Research Translational Institute Department of Molecular Medicine California Campus
« First ‹ Previous 621 - 640 Next › Last »
Showing 20 items per page