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Dennis OConnor

JMIR - Journal of Medical Internet Research - 0 views

shared by Dennis OConnor on 31 Oct 19 - Cached
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    "Journal of Medical Internet Research The leading peer-reviewed journal for digital medicine and health and health care in the internet age"
Dennis OConnor

A mysterious company's coronavirus papers in top medical journals may be unraveling | S... - 0 views

  • On its face, it was a major finding: Antimalarial drugs touted by the White House as possible COVID-19 treatments looked to be not just ineffective, but downright deadly. A study published on 22 May in The Lancet used hospital records procured by a little-known data analytics company called Surgisphere to conclude that coronavirus patients taking chloroquine or hydroxychloroquine were more likely to show an irregular heart rhythm—a known side effect thought to be rare—and were more likely to die in the hospital. Within days, some large randomized trials of the drugs—the type that might prove or disprove the retrospective study’s analysis—screeched to a halt. Solidarity, the World Health Organization’s (WHO’s) megatrial of potential COVID-19 treatments, paused recruitment into its hydroxychloroquine arm, for example.
  • The study doesn’t properly control for the likelihood that patients getting the experimental drugs were sicker than the controls
  • Other researchers were befuddled by the data themselves. Though 66% of the patients were reportedly treated in North America, the reported doses tended to be higher than the guidelines set by the U.S. Food and Drug Administration, White notes. The authors claim to have included 4402 patients in Africa, 561 of whom died, but it seems unlikely that African hospitals would have detailed electronic health records for so many patients, White says.
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  • This was very, very annoying, that The Lancet were just going to let them write this absurd reply … without addressing any of the other concerns,”
  • 200 clinicians and researchers, that calls for the release of Surgisphere’s hospital-level data, an independent validation of the results
  • But the revision had other problems, Chaccour and his colleagues wrote in their blog post. For example, the mortality rate for patients who received mechanical ventilation but no ivermectin was just 21%, which is strikingly low; a recent case series from New York City area found that 88% of COVID-19 patients who needed ventilation died. Also, the data shown in a figure were wildly different from those reported in the text. (Science also attempted to reach Grainger, but received no reply to an email and call.)
  • Surgisphere’s sparse online presence—the website doesn’t list any of its partner hospitals by name or identify its scientific advisory board, for example—have prompted intense skepticism.
  • wondered in a blog post why Surgisphere’s enormous database doesn’t appear to have been used in peer-reviewed research studies until May.
  • how LinkedIn could list only five Surgisphere employees—all but Desai apparently lacking a scientific or medical background—if the company really provides software to hundreds of hospitals to coordinate the collection of sensitive data from electronic health records.
  • Desai’s spokesperson responded to inquiries about the company by saying it has 11 employees and has been developing its database since 2008.
  • The potential of hydroxychloroquine for treating COVID-19 has become a political flashpoint, and the questions around the Lancet paper have provided new fodder to the drug’s supporters. French microbiologist Didier Raoult, whose own widely criticized studies suggested a benefit from the drug, derided the new study in a video posted today, calling the authors “incompetent.” On social media, some speculated that the paper was part of a conspiracy against hydroxychloroquine.
  • Chaccour says both NEJM and The Lancet should have scrutinized the provenance of Surgisphere’s data more closely before publishing the studies. “Here we are in the middle of a pandemic with hundreds of thousands of deaths, and the two most prestigious medical journals have failed us,” he says.
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    Recommended by Mike Kurisu, DO.
Dennis OConnor

Hands-On Data Journalism: Techniques of Analysis and Visualization - Journalism Courses... - 0 views

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    "Through hands-on tutorials over the next four weeks, we want to make you a better data journalist who can use a few free tools and specific techniques to make it easier to mine datasets in search of answers and stories. We will use an example database (about dogs !) along with a dataset of your own choosing."
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    May 31st to June 27 - $95
Dennis OConnor

One Year of the Begin Within Journal! - Begin Within Today - 0 views

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    Christina P. Kantzavelos: "I created this journal because it didn't exist. I was couch-bound due to #lymedisease and a plethora of other diagnoses and symptoms and needed a way to track my physical and mental symptoms, document my nutrition, meds/supplements, challenges, successes, while focusing on self-love, gratitude and visualizations. I needed a way to see the light at the end of the tunnel. "
Dennis OConnor

Genes, Blood Type Tied to Risk of Severe COVID-19 - NIH Director's Blog - 0 views

  • Many people who contract COVID-19 have only a mild illness, or sometimes no symptoms at all. But others develop respiratory failure that requires oxygen support or even a ventilator to help them recover [1]. It’s clear that this happens more often in men than in women, as well as in people who are older or who have chronic health conditions. But why does respiratory failure also sometimes occur in people who are young and seemingly healthy? A new study suggests that part of the answer to this question may be found in the genes that each one of us carries [2]. While more research is needed to pinpoint the precise underlying genes and mechanisms responsible, a recent genome-wide association (GWAS) study, just published in the New England Journal of Medicine, finds that gene variants in two regions of the human genome are associated with severe COVID-19 and correspondingly carry a greater risk of COVID-19-related death.
  • the findings suggest that people with blood type A face a 50 percent greater risk of needing oxygen support or a ventilator should they become infected with the novel coronavirus.
  • Their study included 1,980 people undergoing treatment for severe COVID-19 and respiratory failure at seven medical centers in Italy and Spain.
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  • the researchers compared SNPs in people with severe COVID-19 to those in more than 1,200 healthy blood donors from the same population groups.
  • he researchers did find evidence suggesting a relationship between blood type and COVID-19 risk. They noted that this area also includes a genetic variant associated with increased levels of interleukin-6, which plays a role in inflammation and may have implications for COVID-19 as well.
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  • Franke, Karlsen, and many of their colleagues are part of the COVID-19 Host Genetics Initiative, an ongoing international collaborative effort to learn the genetic determinants of COVID-19 susceptibility, severity, and outcomes
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    "Many people who contract COVID-19 have only a mild illness, or sometimes no symptoms at all. But others develop respiratory failure that requires oxygen support or even a ventilator to help them recover [1]. It's clear that this happens more often in men than in women, as well as in people who are older or who have chronic health conditions. But why does respiratory failure also sometimes occur in people who are young and seemingly healthy? A new study suggests that part of the answer to this question may be found in the genes that each one of us carries [2]. While more research is needed to pinpoint the precise underlying genes and mechanisms responsible, a recent genome-wide association (GWAS) study, just published in the New England Journal of Medicine, finds that gene variants in two regions of the human genome are associated with severe COVID-19 and correspondingly carry a greater risk of COVID-19-related death."
Dennis OConnor

Center of Excellence for Research and Training in Integrative Health - UC San Diego Sch... - 0 views

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    "The Center is actively conducting numerous integrative health projects, including those examining effects of meditation, tai chi, acupuncture, guided imagery, journaling, and Ayurveda in heart failure, myocardial infarction, hypertension, cancer, multiple sclerosis, and pain patients."
Dennis OConnor

Creating Evidence from Real World Patient Digital Data | Frontiers Research Topic - 0 views

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    Camille and Bethany writing a journal piece for this site.
Dennis OConnor

The Future of Care Preserving the Patient-Physician Relationship .pdf - 0 views

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    Recommended by Tyler Orion - John Noseworthy, M.D. Mayo Clinic - The New England Journal of Medicine,
Dennis OConnor

Communication is the most high-impact skill in a knowledge-based economy - Grace Chang,... - 0 views

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    Interview with Grace Chang, CEO of startup Kintsugi, an AI powered voice activated journaling app I've used intermittently for several months. ~ Dennis
Dennis OConnor

Weaponized Health Communication: Twitter Bots and Russian Trolls Amplify the Vaccine De... - 0 views

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    "David A. Broniatowski et al. "Weaponized Health Communication: Twitter Bots and Russian Trolls Amplify the Vaccine Debate", American Journal of Public Health 108, no. 10 (October 1, 2018): pp. 1378-1384. https://doi.org/10.2105/AJPH.2018.304567"
Dennis OConnor

Understanding Medical Research: Your Facebook Friend is Wrong | Coursera - 0 views

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    Recommended by Trish Makowiak: How can you tell if the bold headlines seen on social media are truly touting the next big thing or if the article isn't worth the paper it's printed on? Understanding Medical Studies, will provide you with the tools and skills you need to critically interpret medical studies, and determine for yourself the difference between good and bad science. The course covers study-design, research methods, and statistical interpretation. It also delves into the dark side of medical research by covering fraud, biases, and common misinterpretations of data. Each lesson will highlight case-studies from real-world journal articles. By the end of this course, you'll have the tools you need to determine the trustworthiness of the scientific information you're reading and, of course, whether or not your Facebook friend is wrong. This course was made possible in part by the George M. O'Brien Kidney Center at Yale.
Dennis OConnor

Gmail - Update_ Groundbreaking New Article Accepted.pdf - 0 views

shared by Dennis OConnor on 29 Jan 21 - No Cached
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    January 28, 2021 Dear KRI Research Team, I am very pleased to announce that our latest article "Spiritual Fitness: A New Dimension In Alzheimer's Prevention" which I co-authored with ARPF SAC member, Andrew Newberg, M.D. of Thomas Jefferson University, has been accepted for publication by The Journal of Alzheimer's Disease. Dharma Singh Khalsa, M.D. Founding President / Medical Director Alzheimer's Research and Prevention Foundation (ARPF) www.alzheimersprevention.org drdharma@alzheimersprevention.org
Dennis OConnor

Gmail - Confirmation of Your Story Submission.pdf - 0 views

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    Christina P. Kantzavelos, LCSW #73271, MSW, MLIS *She/Her/Ella Licensed Psychotherapist and Writer (619) 797-6383 Free 15-min Consultation www.beginwithintoday.com hello@beginwithintoday.com Follow us on Instagram @beginwithtoday My name is Christina Kantzavelos, and I am a licensed psychotherapist and coach who specializes in treating clients with chronic illness @beginwithintoday, and the author of the Begin Within Journal. I'm also a gluten-free food, travel and health-conscious writer @buenqamino. Lyme Disease changed the entire trajectory of my life. Although, I was likely infected in middle school when we first noticed the cat scratch stretch marks, and strange symptoms (fatigue, panic attacks, fainting spells), they were manageable. Prior to getting 'really sick' in 2018, I was fearless, traveling the world, conducting international humanitarian work, working full-time, eating whatever I chose (minus gluten, and dairy), and essentially, a yeasayer. As mentioned, I had some ongoing health concerns prior to then, but it did not stop me from living my life.
Dennis OConnor

mRNA Vaccines May Pack More Persistent Punch Against COVID-19 Than Thought - NIH Direct... - 0 views

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    "Earlier this year, clinical trials of the Moderna and Pfizer-BioNTech vaccines indicated that both immunizations appeared to protect for at least six months. Now, a study in the journal Nature provides some hopeful news that these mRNA vaccines may be protective even longer [1]."
Dennis OConnor

Doctors' Expectations Make Pain Treatments More Effective, Research Finds : Shots - Hea... - 0 views

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    "If there's one thing you do want to catch from a trip to your doctor, it's her optimism. A new study, published Monday in the journal Nature Human Behavior, finds that patients can pick up on subtle facial cues from doctors that reveal the doctor's belief in how effective a treatment will be. And that can have a real impact on the patient's treatment outcome."
Dennis OConnor

Love 2.0 - Online Tools - 1 views

  • Given your ever-shifting emotional landscape, any single measure of your positivity ratio can only capture so much.
  • view your score for any given day with some skepticism
  • more trustworthy
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    "Kabir Recommends: The Positivity Self Test is a brief, 20-item survey that asks you to report on your experiences of several emotions over the past 24 hours. Each item on the test includes a trio of words that are related, but not quite the same, for example, "hopeful, optimistic, or encouraged" and "sad, downhearted, or unhappy." With this strategy, each item captures a set of emotions that share a key resemblance and this short test becomes that much more accurate. Keep in mind that the Positivity Self Test merely provides a snapshot of your emotions. Everybody's emotions change by the day, hour, and minute. Some scientists would say that they change by the millisecond. Given your ever-shifting emotional landscape, any single measure of your positivity ratio can only capture so much. One way to overcome such measurement hurdles is to measure repeatedly. Even if you complete the Positivity Self Test as honestly as possible, you should view your score for any given day with some skepticism. Was this particular day representative? Probably not. Days vary. So the more days you can average together to create your estimate, the more trustworthy that estimate becomes. You can get a clear picture of your typical positivity ratio by completing the Positivity Self Test every evening for two weeks. Take the Positivity Self Test In the scientific literature, the Positivity Self Test is also know as the modified Differential Emotions Scale, or mDES, created by Dr. Fredrickson based on an earlier scale developed by pioneering emotion scientist, Carroll Izard. The scholarly references are: Fredrickson, B. L. (in press). Positive emotions broaden and build. In E. Ashby Plant & P. G. Devine (Eds.) Advances in Experimental Social Psychology. Elsevier. Fredrickson, B. L., Tugade, M. M., Waugh, C. E., & Larkin, G. (2003). What good are positive emotions in crises? A prospective study of resilience and emotions following the terrorist attacks on the United States on September 11
Dennis OConnor

How breathing in wildfire smoke affects the body - 0 views

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    "For the more than seven million people in California's Bay Area living through historic wildfires, it's been hard to breathe for the past month. For 29 days the region has been under a "Spare the Air" alert, which means inhaling outdoor air presents a health hazard. Air quality is even worse in Oregon and Washington, and by this morning smoke had stretched all the way to the East Coast and even to Europe. Wildfire smoke contains a variety of gases and particles from the materials that fuel the fire, including ozone, carbon monoxide, polycyclic aromatic compounds, nitrogen dioxide, and particulate matter-pollutants linked to respiratory and cardiovascular illnesses, according to a study in the Journal of the American Heart Association."
Dennis OConnor

Processing The Pandemic : TED Radio Hour : NPR - 0 views

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    This podcasts leads with stories of heathcare workers, especially those of color. There is a writing/journaling thread here as well.
Dennis OConnor

We Thought It Was Just a Respiratory Virus | UC San Francisco - 0 views

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    Recommended by Sharon Wampler: MD PhD by "By June, clinicians were swapping journal papers, news stories, and tweets describing more than three dozen ways that COVID-19, the disease the coronavirus causes, appears to manifest itself. Now researchers at UC San Francisco and around the world have begun taking a closer look at this dizzying array of symptoms to get at the disease's root causes. They are learning from people inside the hospital and out; people on the brink of death and only mildly sick; people newly exposed and recovered; people young and old, Black, brown, and white. And they are beginning to piece together the story of a virus unlike any known before."
Dennis OConnor

Coronavirus Hub: Cell Press - 0 views

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    Recommended by DeAunne Denmark MD Phd, "At Cell Press, we recognize the urgent need to quickly share information about SARS-CoV-2, the coronavirus that causes COVID-19. On this hub page, curated by members of our editorial team, you'll find the latest content about the outbreak as it appears in Cell Press journals."
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