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Dennis OConnor

Love 2.0 - Online Tools - 1 views

  • Given your ever-shifting emotional landscape, any single measure of your positivity ratio can only capture so much.
  • view your score for any given day with some skepticism
  • more trustworthy
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    "Kabir Recommends: The Positivity Self Test is a brief, 20-item survey that asks you to report on your experiences of several emotions over the past 24 hours. Each item on the test includes a trio of words that are related, but not quite the same, for example, "hopeful, optimistic, or encouraged" and "sad, downhearted, or unhappy." With this strategy, each item captures a set of emotions that share a key resemblance and this short test becomes that much more accurate. Keep in mind that the Positivity Self Test merely provides a snapshot of your emotions. Everybody's emotions change by the day, hour, and minute. Some scientists would say that they change by the millisecond. Given your ever-shifting emotional landscape, any single measure of your positivity ratio can only capture so much. One way to overcome such measurement hurdles is to measure repeatedly. Even if you complete the Positivity Self Test as honestly as possible, you should view your score for any given day with some skepticism. Was this particular day representative? Probably not. Days vary. So the more days you can average together to create your estimate, the more trustworthy that estimate becomes. You can get a clear picture of your typical positivity ratio by completing the Positivity Self Test every evening for two weeks. Take the Positivity Self Test In the scientific literature, the Positivity Self Test is also know as the modified Differential Emotions Scale, or mDES, created by Dr. Fredrickson based on an earlier scale developed by pioneering emotion scientist, Carroll Izard. The scholarly references are: Fredrickson, B. L. (in press). Positive emotions broaden and build. In E. Ashby Plant & P. G. Devine (Eds.) Advances in Experimental Social Psychology. Elsevier. Fredrickson, B. L., Tugade, M. M., Waugh, C. E., & Larkin, G. (2003). What good are positive emotions in crises? A prospective study of resilience and emotions following the terrorist attacks on the United States on September 11
Dennis OConnor

Love 2.0 - Online Tools - 0 views

  • Positivity Self Test
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    Recommended by Kabir: "In both Love 2.0 and her earlier book, Positivity, Dr. Barbara Fredrickson describes ground breaking research on our supreme emotion, love, as well as the hidden value of all positive emotions. She encourages readers to experiment with their own lives, finding ways to create more micro-moments of love and positivity that work for them. One way to begin is to keep track of your emotions on a regular basis. Dr. Fredrickson developed the Positivity Self Test featured in her research, her books, and on this website to help you assess your current positivity ratio and track changes in your ratio over time. Just like tracking calories or cash flows can heighten your awareness and in time help you meet your fitness or financial goals, tracking your positivity ratio can help you raise your ratio and build your best future. Results may vary. Best outcomes emerge from sincere and heartfelt efforts to raise your ratio coupled with honest reports of your emotion experiences. Read more about the Positivity Self Test or take the survey here."
Dennis OConnor

The Quantification of Placebo Effects Within a General Model of Health Care Outcomes - 1 views

  • It is proposed that the integration of a scientific model of placebo effects within a general model of health care outcomes could finally end the placebo debate and help to integrate these powerful effects into the health care system.
  • Positive expectancy is recognized as a central component of placebo phenomena by all placebo theorists
  • The proposed model emphasizes that the search for a placebo personality factor must be combined with the measurement of situational expectancy.
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  • an individual who has negative expectations regarding treatment effectiveness would likely produce a stronger than average “nocebo” effec
  • placebo-prone personality
  • Absorption
  • receptivity to sensory experiences and a propensity for sustained, focused attention.
  • Absorption has a genetic basis and is higher in women compared to men
  • Absorption can go in either a positive or negative direction, depending on the situation,
  • Subjects were randomly
  • outcome measures
  • based on three scales
  • includes scales measuring fatigue, pain, and spasticity
  • Judgment that the placebo was the active device resulted in a positive score with a magnitude of the confidence rating.
  • if judgment was that the placebo was the placebo device, the confidence rating of the placebo was a negative score, with the magnitude of the rating.
  • scored in the upper quintile on improved quality of life, as measured by the 3 QLI (an average of three symptom scales measuring pain, fatigue, and spasticity) after receiving treatment with a sham device.
  • placebo responders
  • Placebo responders scored higher on Absorptio
  • Placebo responders gave higher confidence ratings that the placebo was the active device
  • This study provides support for a two-factor model of placebo responding.
  • importance of positive expectancy
  • both cognitive and emotional factors mediate these effects
  • Positive beliefs or confidence in the treatment coupled with a desire to feel better activate processes that result in positive outcomes.
  • positive expectancy is an essential factor
  • disease-specific pathways that are activated by positive expectancies have helped to transform this “soft” psychologic factor into a “hard” physiologic factor with physically measurable effects.
  • While the shift from negative to positive affect may be the hallmark of placebo responding, negative affect alone is not sufficient and can play a role in people who worsen as well (nocebo effects).
  • Numerous research studies have reliably shown that Absorption is modestly (yet very consistently) correlated with hypnotizability.
  • Hypnotizability is often associated with “suggestibility,” with perhaps the sense of a weak-willed character or unbridled fantasy-proneness, the “unreality factor” that has plagued placebo theory for decades.
  • enlightening to view these individual differences as a natural endowment in self-regulation skills: a potential innate strength rather than a simple weakness with a natural ability for self-directed healing in response to health challenges.
  • Decades of research have reliably demonstrated that individuals scoring high in Absorption can skillfully modulate an impressive array of physiologic processes in laboratory settings.
  • The literature suggests that the mind–body control of high Absorption scorers is similar to the self-regulation skills that many are seeking to develop with meditation, mindfulness, yoga, and qigong.
  • The regular practice of mind–body control and the cultivation of positive attitudes may enhance regulation at higher levels, improving the regularity of circadian and other rhythms,
  • points to the role of both expectation and conditioning, with conditioning playing a greater role in certain pathways such as immune modulation.
  • somatic vulnerability of high Absorption individuals who suffer from negative biases in perception.
  • nocebo phenomena described by these researchers are important for our model as they directly illustrate the power of a negative interaction of the two factors.
  • Many physicians admit to prescribing placebos to contribute to patient wellness, even though this “dark secret” is not condoned and is considered to be ethically questionable.
  • High Absorption individuals may benefit from encouragement to utilize their innate self-regulation skills toward maximum therapeutic effect.
  • ersons with average Absorption scores can be encouraged to become more skilled at self-regulation through mind–body therapies
  • The model does not specifically address the many factors that contribute to confidence in the treatment, such as cost, pill color, pill size, or confidence-enhancing paraphernalia.
  • The role of provider and patient interaction are also not specifically addressed.
  • he model also does not directly address the role of stress reduction
  • The strength of placebo responding in domains such as pain and depression clearly indicate the importance of the shift from a negative to a positive state.
  • the unresolved issue of why some people respond to placebos whereas others do not
  • asic two-factor model can be further tested with the basic measurement tools of expectancy and Absorption,
  • Conclusions
  • the recognition that positive expectancy and expert self-regulation skills significantly contribute to health outcomes can help to integrate these powerful effects into the health care system
  • The “positive psychology” movement is shifting attention to the power of positive expectation
  • undermining nature of negative expectancy and pessimistic language, especially in vulnerable populations such as those with pain and depression
  • Practitioners of the art of health care have always recognized the importance of motivated and empowered patients and the power of a kind word and a ray of hope.
  • This is the time to quantify these factors, integrating art and science, and finally solving (and forgiving Descartes for) the mind–body problem.
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    "The topic of placebo effects is distinguished by decades of keen scientific interest1-4 coupled with a general skepticism regarding the ultimate significance of these phenomena. The importance of psychologic factors in mediating these effects may contribute to the attitude that placebo effects are not as substantial as a therapeutic effect produced by a drug. Complementary and alternative therapies have sometimes been dismissed as "mere placebos." However, recent studies have provided compelling evidence that placebo effects are physiologically measurable with condition-specific pathways.5"
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    Dr. Jake Fleming recently suggested these potent keywords: quantifiable placebo The keywords led to this article. I find it affirming and empowering.
Dennis OConnor

Positivity: Groundbreaking Research Reveals How to Embrace the Hidden Strength of Posit... - 0 views

  • World renowned researcher Dr. Barbara Fredrickson gives you the lab-tested tools necessary to create a healthier, more vibrant, and flourishing life through a process she calls "the upward spiral." You’ll discover:
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    Recommended by Kabir I've been enjoying this book on the subject of Positivity in the research that has been done on the construct. As it turns out there is a mathematical tipping point for when positivity in our lives moves from an inert force to one that can dramatically impact and improve the qualities of our experience. Roughly speaking this is 3 positive thoughts/emotional experiences to 1 negative thought or emotional experience. When we reach this ratio (which is above average) on a consistent basis, it has meaningful impact on our health and well-being. So I wanted to invite you to this exercise with me: Throughout your day, each time you notice a negative thought or emotion, first feel, recognize, and accept the experience, and then Complement it by recalling 3 distinct things that you are grateful for, love, or enjoy - in essence bring about 3 positive thoughts/emotional experiences. Let's see what this does for our health and well-being! :-)
Dennis OConnor

The Lyme Disease Biobank - Characterization of 550 Patient and Control Samples from the... - 0 views

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    Recommended by Sharon Wampler "ABSTRACT Lyme disease (LD) is an increasing public health problem. Current laboratory testing is insensitive in early infection, the stage at which appropriate treatment is most effective in preventing disease sequela. The Lyme Disease Biobank (LDB) collects samples from individuals with symptoms consistent with early LD presenting with or without erythema migrans (EM) or an annular, expanding skin lesion, and uninfected individuals from endemic areas. Samples were collected from 550 participants (298 cases and 252 controls) according to IRB-approved protocols and shipped to a centralized biorepository. Testing was performed to confirm the presence of tick-borne pathogens by real-time PCR, and a subset of samples was tested for Borrelia burgdorferi by culture. Serology using the CDC's standard two-tiered testing algorithm (STTTA) for LD was performed on all samples. LD diagnosis was supported by laboratory testing in 82 cases, including positive STTTA, PCR, culture, or 2 positive ELISA's with EM >5 cm, while the remaining 216 cases had negative laboratory testing results. For the controls, 43 were positive on at least one of the tiers, and 6 were positive by STTTA. This collection highlights and reinforces the known limitations of serologic testing in early LD, with only 29% of individuals presenting with EM >5 cm yielding a positive result using the STTTA. Aliquots of whole blood, serum, and urine from clinically characterized patients with and without LD are available to investigators in academia and industry for evaluation or development of novel diagnostic assays for LD, to continue to improve upon currently available methods."
Dennis OConnor

Coronavirus Antibody Tests: Can You Trust the Results? - The New York Times - 0 views

  • Of the 14 tests, only three delivered consistently reliable results. Even the best had some flaws.
  • Each test was evaluated with the same set of blood samples: from 80 people known to be infected with the coronavirus, at different points after infection; 108 samples donated before the pandemic; and 52 samples from people who were positive for other viral infections but had tested negative for SARS-CoV-2.
  • these tactics mean nothing if the test results can’t be trusted
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  • The proportion of people in the United States who have been exposed to the coronavirus is likely to be 5 percent or less, Dr. Hensley said. “If your kit has a 3 percent false-positive, how do you interpret that? It’s basically impossible,” he said. “If your kit has 14 percent false positive, it’s useless.”
  • The duo recruited Dr. Jeffrey Whitman and Dr. Caryn Bern, who last year published an analysis of antibody tests for Chagas disease. Other graduate students and postdoctoral fellows volunteered to help perform the evaluations.
  • In all, the investigators analyzed 10 rapid tests that deliver a yes-no signal for antibodies, and two tests using a lab technique known as Elisa that indicate the amount of antibodies present and are generally considered to be more reliable.
  • The Bay Area team finished evaluating 12 tests in record time, less than a month. By comparison, the Chagas project required a team of three people working for more than a year just to compare four tests.
  • Having a study design already in hand helped speed the work, but there was one key difference. Decades of data have shown that Chagas disease elicits lifelong immunity.
  • Already Americans are scrambling to take antibody tests to see if they might escape lockdowns. Public health experts are wondering if those with positive results might be allowed to return to work.
  • Tests made by Sure Biotech and Wondfo Biotech, along with an in-house Elisa test, produced the fewest false positives.
  • A test made by Bioperfectus detected antibodies in 100 percent of the infected samples, but only after three weeks of infection.
  • None of the tests did better than 80 percent until that time period, which was longer than expected, Dr. Hsu said.
  • the tests are less likely to produce false negatives the longer ago the initial infection occurred,
  • There are multiple tests that have specificities greater than 95 percent.
  • Dr. Krammer has developed a two-step Elisa test that he said has 100 percent specificity and delivers a measure of the quantity of IgM and IgG antibodies a person has.
  • Scanwell Health, a Los Angeles-based start-up, has ordered millions of test kits from Innovita, a Chinese manufacturer, and has applied to the Food and Drug Administration to market the tests for at-home use.In the new study, the Innovita test detected antibodies in 83 percent of infected people and yielded a false-positive rate of 4 percent.
  • Scanwell Health, said the study looked at an earlier version of Innovita’s test and not the “newer, improved version” his company had ordered. “It will be interesting to see how it performs,”
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    "A team of scientists worked around the clock to evaluate 14 antibody tests. A few worked as advertised. Most did not."
Dennis OConnor

Wearable sensor data and self-reported symptoms for COVID-19 detection | Nature Medicine - 0 views

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    "Abstract Traditional screening for COVID-19 typically includes survey questions about symptoms and travel history, as well as temperature measurements. Here, we explore whether personal sensor data collected over time may help identify subtle changes indicating an infection, such as in patients with COVID-19. We have developed a smartphone app that collects smartwatch and activity tracker data, as well as self-reported symptoms and diagnostic testing results, from individuals in the United States, and have assessed whether symptom and sensor data can differentiate COVID-19 positive versus negative cases in symptomatic individuals. We enrolled 30,529 participants between 25 March and 7 June 2020, of whom 3,811 reported symptoms. Of these symptomatic individuals, 54 reported testing positive and 279 negative for COVID-19. We found that a combination of symptom and sensor data resulted in an area under the curve (AUC) of 0.80 (interquartile range (IQR): 0.73-0.86) for discriminating between symptomatic individuals who were positive or negative for COVID-19, a performance that is significantly better (P 
Dennis OConnor

Fast ForWord Reading Intervention and Evidence for ESSA | Scientific Learning - 0 views

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    "Fast ForWord has 21 studies that meet WWC Evidence Standards for Adolescent Literacy, Beginning Reading and English Language Development - the most of any reading intervention evaluated. Positive effectiveness ratings and improvement indices were found for: Alphabetics Reading Fluency Comprehension English Language Development (largest improvement index of interventions evaluated) When compared to other interventions evaluated by WWC, Fast ForWord is the only intervention with positive effects for English Learner AND Literacy Outcomes for students grades K-10 in individual, small group, and whole class settings."
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    Keywords: neuroscience reading
Dennis OConnor

Brain Health In The Time of the Coronavirus - BrainHQ from Posit Science - 1 views

    • Dennis OConnor
       
      I've done 163 days of BrainHQ Training. I have experienced significant improvement in all categories of training: Attention, Brain Speed, Memory, People Skills, Intelligence, Navigation. Basic training schedule is every other day for 30 minutes.
  • If staying at home can contribute to a decline in our physical health—which we can address with an exercise program—what does staying at home and socially isolating do to our cognitive health?
  • while we are staying at home and avoiding social contact, we’re depriving our brains of the cognitive stimulation and new learning that naturally come through our everyday lives and interactions with friends, co-workers, and even random strangers.
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  • brain plasticity is a two-way street. In the same way that the brain can build itself through positive brain plasticity, the brain can “unbuild” itself through negative brain plasticity.
  • our favorite topic at Posit Science: brain plasticity, the science of how the brain rewires itself through learning and experience.
  • get your quarantine cognitive exercise program started:
  • New learning
  • Cognitive engagement
  • BrainHQ
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    I found Posit Science and BrainHQ thanks to a suggestion from Dr. Kurisu. He recommended Norman Doige's books, The Brain That Changes Itself; Personal Triumphs from the Frontiers of Brain Science and The Brain's Way of Healing: Remarkable Discoveries and Recoveries from the Frontiers of Neuroplasticity. One of the case studies is about Dr. Michael Merzenich, a research who was vilified by the medical establishment for investigating neuroplasticity. Great story. Merzenich is a founder of PositScience and BrainHQ.
Dennis OConnor

Study: Brain Exercises Provide Breakthrough Treatment for Geriatric Depression - BrainH... - 0 views

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    "SAN FRANCISCO - For the first time in a randomized controlled trial, brain exercises were shown effective in addressing depression in treatment-resistant older patients, who had previously used anti-depressive drug therapy without success. The exercises were shown to improve not only mood, but also the often-unaddressed cognitive deficits associated with geriatric depression. The study used neuroplasticity-based exercises from BrainHQ, the brain training app from Posit Science, plus two new exercises designed for the study."
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    While the term 'geriatric depression' tastes like ashes, I was pleased to see this research. I've been working with BrainHQ for some time and I can feel the neuroplastic growth.
Dennis OConnor

Antibodies and coronavirus immunity: everything we know. - 0 views

  • Antibodies will probably be key to getting us out of this—in one way or another. By Shannon Palus
  • one promising solution is the idea of antibodies and antibody tests.
  • as with everything about the virus, it’s not yet clear what role antibody tests will be able to play in getting us out of this, and it’s even not completely clear how much getting the coronavirus once prevents you from getting it again
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  • What is an antibody?
  • How do I get the anti-coronavirus antibodies?
  • The most basic (and worst) way to get the antibodies is to get the coronavirus.
  • So once you have the antibodies, you are immune against the virus?
  • We can’t count on immunity right now.
  • Wait, but aren’t there people out there who have gotten the novel coronavirus twice, within a short period of time?
  • So if I’ve been sick with COVID-19 already, should I assume I’m immune, or not?
  • OK. Let’s get to the tests. What’s the deal?
  • The fantasy of antibody tests is that they might be deployed to help us determine who can go back to work and school and normal social gatherings.
  • That sounds very promising!
  • even though the tests can provide a guess at immunity, even a positive result cannot guarantee anything.
  • So what are antibody tests actually good for right now?
  • They are tools to gather more data.
  • This is why the National Institutes of Health is currently recruiting 10,000 volunteers to take antibody tests.
  • There’s one clear way that they could help right now on an individual level: We’ve all been asked to basically assume we have the coronavirus; an antibody test could help clarify our own narratives.
  • If you test positive, you can also apply to donate plasma.
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    Recommended by Dr. Michael Kurisu D.O. 4/15/2020 Good summary. Not scientific or too detailed but good overall big picture view
Dennis OConnor

8-Week Evidence-Based LIGHT Self-Efficacy Course (Saturday afternoons) Registration, Sa... - 0 views

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    About LIGHT After eight years of research and development, UC San Diego will debut a novel program this September, called LIGHT (Light Induced Guided Healing Therapy) through its Centers for Integrative Health. Developed by Paula Marie Jackson and Tom Thudiyanplackal, LIGHT is an evidence-based protocol that empowers the individual with a self-care approach to enhancing self-efficacy, which is an individual's belief in his or her innate ability to achieve goals. This protocol has been shown to improve mood, decrease fatigue, and positively affect quality of life.
Dennis OConnor

First U.S. Company Announces an Upcoming Home COVID-19 Test | Time - 0 views

  • Food and Drug Administration allowed certified labs, including commercial lab testing companies, to develop and distribute COVID-19 tests on Feb. 29.
  • People can order the Everlywell COVID-19 test on the company’s website, after first answering questions about their basic health, symptoms and risk factors for the coronavirus disease. A doctor still needs to prescribe the test, so telemedicine doctors from PWNHealth, a national network of physicians who prescribe diagnostic tests, then reviews these answers to determine if a person qualifies for testing, based on criteria established by the Centers for Disease Control and Prevention.
  • Currently, because COVID-19 tests are not plentiful in the U.S., doctors are trying to rule out other respiratory diseases like flu first, and only ordering tests for people with symptoms who also have other risk factors for infection, such as being in close contact with others who have been diagnosed.
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  • If the telemedicine doctor decides to prescribe an Everlywell COVID-19 test, the company says it will send the $135 test kit in two days (customers can pay $30 more to receive the kit overnight).
  • As with many of the commercially available tests, this one extracts SARS-CoV-2, the virus behind COVID-19, from the sample and then probes for specific genetic signatures of the virus.
  • If the test is positive, the company also provides a full telemedicine consultation with one of around 200 physicians that is included in the cost of the test.
  • Everlywell says it is ready to ship 30,000 COVID-19 tests, and plans to expand the number of labs processing the sample
  • kits will depend on the availability of swabs for collecting samples
  • global shortage of swabs for any lab performing the test.
  • We’re working hard to ramp up weekly capacity to test 250,000 Americans,” says Cheek
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    DeAunne Denmark, M.D. Phd - I was just reading about this last night. Dr forum blowing up about it. It could be a gigantic win for EverlyWell (and at-home D-T-C Direct-to-Consumer) if they do it right. But *must* do it right, e.g. including transparency re: methods, interfacing with HCP/EMRs, etc. The big issue may be collection variability, not unlike the microbiome. Nasal swab not trivial, more talk now about collection variability possibly accounting for a large proportion of "negs" turning positive. Hate to see a lot of false confidence running around at large infecting others.
Dennis OConnor

Osteopathy and Spainsh Influenza.pdf - 1 views

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    Dr. Michael Kurisu D.O. - This is an article that is well known in our Osteopathic community. Seems to be quite relevant in today's crisis. Although… there are several shortcomings to this article. - it was published over a century ago - it is a retrospective analysis - they did have or keep good public health data on infectivity and virulence and positive tests (We STILL DONT DO THIS!!!) - there is no documentation about what techniques used etc… Nonetheless… for an article that is over 100 years old, it IS a data point. And the data from back then shows that during Spanish influenza… the patients who saw a D.O. had a medical death rate that was 40X lower than the general population… Just another reason to have good D.Os around in the primary care workforce.
Dennis OConnor

Advice from Dr. Mimi Guarneri - Integrative Medicine - 1 views

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    "Thankfully, there are many things we can do as individuals and communities that may be helpful. It is important to remain calm and think clearly. Remember that our positive attitudes go a long way in protecting health, enriching our daily lives, and supporting the ones we love. Here is a list of things one can do at home to help in these uncertain times:"
Dennis OConnor

Aging Successfully | Conversation | re'flect - 0 views

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    "Gray Matters, the new podcast series, will continue our mission to discuss how we can all age successfully.   re'flect, the documentary series has aired nationally on over 50 PBS stations in over 40 cities and is spreading the positive aging conversation around the US. "
Dennis OConnor

Memory enhancement in healthy older adults using a brain plasticity-based training prog... - 1 views

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    Henry W. Mahncke*†, Bonnie B. Connor*, Jed Appelman*, Omar N. Ahsanuddin*, Joseph L. Hardy*, Richard A. Wood*,Nicholas M. Joyce*, Tania Boniske*, Sharona M. Atkins*, and Michael M. Merzenich*†‡*Posit Science Corporation, 225 Bush Street, San Francisco, CA 94104; and‡Keck Center for Integrative Neurosciences, University of California, 513 ParnassusAvenue, Box 0472, Room HSE-836, San Francisco, CA 94143Contributed by Michael M. Merzenich, June 27, 2006
Dennis OConnor

EpigeneticsRX - 0 views

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    "Precise. Personalized. Prevention. Express your best DNA - the power to impact genetic expression is in your hands. Epigenetics is the study of how lifestyle & environment influence the expression of your genes." OUR MISSION is to empower and inspire providers and patients in optimizing genetic potential through precise, personalized protocols that positively impact patients' health and future generations.
Dennis OConnor

The Power of the Process: Creating Positive Outcomes with David Rakel, MD | The Institu... - 0 views

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    "In this podcast, IFM's Director of Medical Education, Dan Lukaczer, ND, interviews researcher, educator, and clinician David Rakel, MD, on the power of empathy, compassion, the placebo effect, and the patient story. In particular, they explore how empathy and sympathy can lead to burnout, while compassion can be restorative." shared by Vicky Newman
Dennis OConnor

Pioneering Scientist and Innovator Larry Smarr Retires - 0 views

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    "After 20 years at UC San Diego, Larry Smarr will step down as the director of the California Institute for Telecommunications and Information Technology (Calit2) and retire as a distinguished professor from the Jacobs School of Engineering's Computer Science and Engineering Department at the end of this month. Dr. Ramesh Rao, professor of electrical and computer engineering at the Jacobs School of Engineering, will serve as interim director of Calit2, in addition to his current position as the director of the Qualcomm Institute."
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