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"Biologists at the University of Rochester have determined how blind mole rats fight off cancer -- and the mechanism differs from what they discovered three years ago in another long-lived and cancer-resistant mole rat species, the naked mole rat."

Naked mole rats are hairless, blind, underground dwellers that are remarkably impervious to cancer. But why you ask? Well, researchers at the University of Rochester asked that same question and it turns out a cluster of genes, called the INK4 locus, is the answer. This locus, also found in humans and mice, uses that cluster to carry instructions, or encode, for several cancer fighting proteins.

When you leave the house, does your dog or cat even remember you? Read More: A Rat's Tenacious Memory http://www.indiana.edu/~rcapub/v17n1/... "In the wild, Rats scramble over the network of pathways they have created, combing their surroundings for food, water, mates, and shelter. Their movements may seem automatic to the untrained eye, simply a reflexive pattern. Decades ago, however, researchers established that Rats know where they are going and remember where they have been."

"Scientists have sequenced the complete genome of the naked mole rat, a pivotal step to understanding the animal's extraordinarily long life and good health."

Charles is an African giant pouched rat, a species endemic to sub-Saharan Africa. He's also a pioneer, one of 30 of his species that live and work here in Morogoro, a few hundred kilometers west of Tanzania's largest city, Dar es Salaam, on a program to sniff out tuberculosis (TB).

Scientists work with animal models to better understand type 2 diabetes to treat the disease. They have developed specialized animal models that mimic the condition.  One line of mice, known as KK mice, develop obesity and glucose intolerance that lead to type 2 diabetes. Another rodent model, the Zucker diabetic fatty rat, is bred to be a precise model of human type 2 diabetes.

Rat-smell-fear epigenetic summary in cartoons

" The typical naked mole rat lives 25 to 30 years, during which it shows little decline in activity, bone health, reproductive capacity and cognitive ability. What is the secret to this East African rodent's long, healthy life?"

In a first, scientists led by Kamel Khalili, director of the Comprehensive NeuroAIDS Center at Temple University, report in the journal Gene Therapy that they have for the first time successfully eliminated HIV genes from the genomes of mice and rats infected with the virus.

The study is the first to examine all of the gene networks affected by fructose that result in changes to brain function and metabolism-more than 20,000 genes in total. Although the study was conducted using rats, the researchers report that the majority of the sequenced genes are comparable to those in humans, including more than 200 genes in the hippocampus, a brain area crucial to memory, and 700 in the hypothalamus, the seat of the brain's metabolic control center.

Controversial new research suggests that contrary to the history books, the "Black Death" that devastated medieval Europe was not the bubonic plague, but rather an Ebola-like virus. History books have long taught the Black Death, which wiped out a quarter of Europe's population in the Middle Ages, was caused by bubonic plague, spread by infected fleas that lived on black rats. But new research in England suggests the killer was actually an Ebola-like virus transmitted directly from person to person.

Unlike the rats favoured as animal models for many other diseases, dogs develop haemophilia naturally, have enough blood to contribute to research studies and live long enough to reveal long-term outcomes of treatments. "We have a 60-year track record now showing that if it works well in dogs, it's likely going to work well in humans," says Nichols.

Scientists once shied away from naming research animals, and many of the millions of mice and rats used in U.S. research today go nameless, except for special individuals. But a look at ​many facilities suggests that most of the ​other ​891,161 ​U.S. ​research animals ​have proper names​, including nonhuman primates, dogs, pigs, rabbits, cats, and sheep​.

You may remember neuroscientist Miguel Nicolelis - he built the brain-controlled exoskeleton that allowed a paralyzed man to kick the first ball of the 2014 World Cup. What's he working on now? Building ways for two minds (rats and monkeys, for now) to send messages brain to brain. Watch to the end for an experiment that, as he says, will go to "the limit of your imagination."

Recently, in an article in the New Republic, 'The Animals That Can Save Your Life', journalist Emma Young introduces readers to the emerging science of training animals to detect things humans cannot.

"There has been an over-reliance on male animals in preclinical research in the past, and as we have worked to study female specific physiological conditions, we became aware that even many aspects of our basic model of diet induced obesity are different in females," Erin Giles, assistant professor at Texas A&M University and lead author of the study, said in a press release.

Highlighting role of animal research in human health.  A visually appealing website with an array of research summaries.