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Interrupted case study of whooping cough.

Links to wide array of virtual labs

In this activity, students learn why evolution is at the heart of a world health threat. They will investigate the increasing problem of antibiotic resistance in such menacing diseases as tuberculosis and influenza. Students take on the role of staff at a public health agency who are trying to communicate the widespread problem of evolving disease-causing agents to the public.

list of infectious viral and bacterial disease, Rhode Island Dept of Health

3:00 There are a few reasons that modern humans have to brush our teeth to stay healthy, even though our primate cousins don't. Grab your floss and find the answers inside!

Links to teacher's guide for October articles Eating with your eyes: The Chemistry of Food Colorings Tooth Decay: A Delicate Balance Probiotics: Good bactria good health Dirt? Who needs it? How hydroponics is poised to change the world Light in the cellar of the sea

Where does bread get its fluffiness? Swiss cheese its holes? And what makes vinegar so sour? These foods may taste completely different, but all of these phenomena come from microorganisms chowing down on sugar and belching up some culinary byproducts. Erez Garty shows how your kitchen functions as a sort of biotechnology lab, manned by microorganisms that culture your cuisine.

An exciting new test might help us save antibiotics. Needing only a drop of blood, researchers at Duke have developed a rapid assay that can tell viral infections-which generally can't be treated-from bacterial ones that may benefit from antibiotics. While I don't usually write about drugs or products in development, this test piqued my interest and left me excited about its potential to help contain antibiotic overuse.

This case study presents the story of Phil, an undergraduate majoring in biology, whose Russian cousin Dimitri has contracted tuberculosis (TB) from inmates at the prison where he works.  Phil learns that his cousin's failure to complete his antibiotic regimen likely contributed to the evolution of antibiotic-resistant TB in his body.  Phil consults with his friend Stacy, and together they try to understand Dimitri's condition by applying what they are learning in their genetics lab experiment about the role of random mutation in bacterial evolution (including the development of antibiotic resistance) through Luria- Delbrück fluctuation analysis. The same analysis includes calculation of the mutation rate, which Phil realizes is sufficient to cause MRSA and other antibiotic-resistant infections. This case study was originally developed for concurrent use in freshman/sophomore-level genetics, elementary statistics, and precalculus. However, it is also very appropriate for courses in introductory biology, evolutionary biology, and biostatistics. The teaching notes discuss various ways to run the case depending on the mathematics and biology background of students.

Until very recently it was thought that just one bacterium was to blame for causing Lyme disease in humans. But it turns out that a second, related bug can cause it too.

In July, the AP reported that its first round of tests showed disease-causing viruses directly linked to human sewage at levels up to 1.7 million times what would be considered highly alarming in the U.S. or Europe. Experts said athletes were competing in the viral equivalent of raw sewage and exposure to dangerous health risks almost certain. The results sent shockwaves through the global athletic community, with sports officials pledging to do their own viral testing to ensure the waters were safe for competition in next year's games. Those promises took on further urgency in August, after pre-Olympic rowing and sailing events in Rio led to illnesses among athletes nearly double the acceptable limit in the U.S. for swimmers in recreational waters.

Collection of Biology resources

This case is an account of the events that led Drs. Robin Warren and Barry Marshall to the bacterial theory of ulcers. The two physicians refused to accept the standard explanations for what they had observed and instead developed an alternative hypothesis, saving countless patients from unnecessary pain and suffering. Along the way they transformed the way the medical community viewed peptic ulcer disease. The case shows the importance of curiosity, serendipity, and tenacity in scientific inquiry; how science is built upon the work of others; how assumptions can cloud people's views, leaving them closed to new ideas; and how scientific "truth" can and does change when faced with new data and new interpretations. It is appropriate for use in any course at the high school or undergraduate level that teaches students about the scientific method and/or the sociology, nature, and history of science.

crowd-sourced list of resources to support microbiology content

This interrupted case study for the flipped classroom introduces the human microbiome from the perspective of one of its occupants, Heidi Helicobacter (Helicobacter pylori).  Heidi lives in the gut of Kristen, a college student, and discusses her fellow microbial inhabitants, functions of these various microbes, and alludes to factors that can disrupt the healthy human microbiome. Students prepare for class by viewing several brief videos and then discuss in class whether Kristen should undergo a fecal microbiota transplant to treat her Clostridium difficile infection.  A lab component has students model, using colored beads, how antibiotics can act as a selective agent for drug-resistant microbes such as C. difficile. The case concludes with Kristen about to give birth to a new baby several years later.  Students listen in as Kristen's microbes discuss the formation of the new baby's microbiome. The case has been used successfully in a general biology class and could easily be adapted for a microbiology, human physiology, ecology, or evolution course.

Behold the microscopic jungle in and around you: tiny organisms living on your cheeks, under your sofa and in the soil in your backyard. We have an adversarial relationship with these microbes -- we sanitize, exterminate and disinfect them -- but according to microbiologist Anne Madden, they're sources of new technologies and medicines waiting to be discovered. These microscopic alchemists aren't gross, Madden says -- they're the future.

While the "vaccine controversy" has made headlines since the late 1990s, the emergence and popularity of social media has created a public opinion space bursting with pseudoscience, debatable claims and anecdotes regarding the value and importance of childhood vaccines. Because college students get a good deal of news and information from these resources, it is imperative that they distinguish science from pseudoscience and do not perpetuate rumor and falsehoods.  In this case study, written for lower division non-science majors, students will view videos on the scientific method and a mock talk show, analyze data, and scrutinize social media posts.  One of the takeaway points is that if a post/blog/interview identifies a victim, villain, and hero then the student should suspect a story grounded in belief involving pseudoscience.  Following completion of the case, students will hopefully come to conclusions about vaccines based more in the realm of science rather than pseudoscience and continue to apply the scientific method when evaluating social media posts on other scientific topics.