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A zebrafish model of a rare genetic disease has revealed an unexpected regulatory pathway for cholesterol absorption and processing. The findings, reported in the Journal of Molecular Medicine, were "quite surprising and have the potential to teach us about the basic physiology of cholesterol management," said Ela Knapik, M.D., associate professor of Medicine and Cell and Developmental Biology.

The test, dubbed VirScan, and research surrounding it is the subject of a new report published in the journal Science. For the study, scientists screened sera, a part of the blood, from 569 people in the U.S., South Africa, Thailand, and Peru and tested for more than 200 types of viruses.

WEDNESDAY, April 22, 2015 (HealthDay News) -- In a step toward personalized vaccines against cancer, scientists report they have developed an immune-system therapy that knocks out several types of aggressive tumors in mice. German researchers said the findings, reported April 22 in the journal Nature, could lead to a "blueprint" for developing tailored vaccines for a range of cancers. Such vaccines would be designed for individual patients, based on the specific genetic mutations in their tumors.

A study in monkeys offers the first evidence that a leading drug developed to fight Ebola works against the strain causing the current outbreak in West Africa. Six animals were infected with a very high dose of the virus and then, three days later, half were given the drug, TKM-Ebola-Makona, which was designed specifically to fight the West African strain. The monkeys that received the drug survived, but all three untreated monkeys died, researchers reported on Wednesday in the journal Nature.

Scientists are now one step closer to understanding how genetic mutations contribute to autism. In a study released Thursday in the journal Cell, experts from UNC School of Medicine discovered how one specific autism-linked gene mutation actually works

A package of papers investigates the functional regulatory elements in genomes that have been obtained from human tissue samples and cell lines. The implications of the project are presented here from three viewpoints. 

A team of scientists, in a groundbreaking analysis of data from hundreds of sources, has concluded that humans are on the verge of causing unprecedented damage to the oceans and the animals living in them. "We may be sitting on a precipice of a major extinction event," said Douglas J. McCauley, an ecologist at the University of California, Santa Barbara, and an author of the new research, which was published on Thursday in the journal Science.

Even if you look like your mother, an innovative study suggests that not only humans but, in fact, all mammals are genetically more like Dad. We inherit equal amounts of genetic material from each parent, yet that coming from our father's side is more likely to take action, according to the study that was published in the journal Nature Genetics.

That's why a paper published Thursday in the journal Genetics in Medicine is so remarkable. The paper identifies NGLY1 deficiency as an inherited genetic disorder, caused by mutations in the NGLY1 gene. The researchers have confirmed eight patients with these mutations who share several symptoms, including developmental delays, abnormal tear production and liver disease.

Scientists said Wednesday a new drug tested on monkeys provided an astonishingly effective shield against an animal version of the AIDS virus, a major gain in the quest for an HIV vaccine. Macaque monkeys given the drug were able to fend off high, repeated doses of the simian version of the human immunodeficiency virus (HIV), they reported in the journal Nature.

Your mother's DNA may have determined your eye color, but some traits that you thought came from her may instead have come from the DNA of bacteria she passed on to you soon after birth, a new study finds. The study found that a mother mouse can pass along to her offspring a susceptibility to intestinal disorders, such as inflammatory bowel disease, by way of a gut-residing bacterium called Sutterella, the researchers reported in the journal Nature on Feb. 16.

Washington, D.C. - April 10, 2015 - Human norovirus may infect our canine companions, according to research published online April 1 in the Journal of Clinical Microbiology, a publication of the American Society for Microbiology. That raises the possibility of dog-to-human transmission, said first author Sarah Caddy, VetMB, PhD, MRCVS, a veterinarian and PhD student at the University of Cambridge, and Imperial College, London, UK. Norovirus is the leading cause of food-borne illness in the United States, according to the Centers for Disease Control and Prevention (CDC).

American school systems tend to put-off studying the sciences in-depth until high school. Only recently has this practice come under long-overdue scrutiny. Over 65 percent of scientists reported that their interest in science began before their middle school years, according to the International Journal of Science Education. In order to have curious, scientifically literate students who can bring innovation to a technologically based economy, it is essential that they have a strong foundation of science, technology, engineering, and mathematics, with classes in these subjects beginning in the elementary grades. Perhaps the solution lies in a connected curriculum.

Now a study of 15 Finnish families, published in the Journal of Medical Genetics, provides the first proof that musical ability is indeed linked to genes.

When the scientists analyzed the water under a microscope, they quickly deduced what was causing the red liquid. In a newly-published study in Spanish Royal Society of Natural History Journal, they reveal that the culprit is Haematococcus pluvialis, a freshwater green microalgae that's capable of synthesizing a red carotene pigment called astaxanthin.

In the blood of a survivor of the recent Ebola outbreak, a team of researchers has discovered a number of antibodies that seem to successfully combat the deadly virus in mice. The findings, published in the journal Science, may help point scientists in the right direction for developing a vaccine that could protect against the disease.

Research has revealed striking differences in the trillions of bacteria - a.k.a., the microbiome - in the intestines of children with and without autism. But the gut bacteria in individuals with autism aren't just different. Researchers at the California Institute of Technology have shown for the first time that they may actually contribute to the disorder. They reported in the journal Cell in December 2013 that an experimental probiotic therapy alleviated autism-like behaviors in mice and are already planning a clinical trial.

One concern repeatedly raised by critics who don't want the FDA to give the transgenic fish the green light: What would happen if these fish got out of the land-based facilities where they're grown and escaped into the wild? Would genetically modified salmon push out their wild counterparts or permanently alter habitat? In a review paper published this month in the journal BioScience, scientists tackle that very question. Robert H. Devlin, a scientist at Fisheries and Oceans Canada, led a team that reviewed more than 80 studies analyzing growth, behavior and other trait differences between genetically modified and unaltered fish. The scientists used this to predict what might happen if fish with modified traits were unleashed in nature.

If the lab technique works in the field, it could offer a new way of stopping the biting insects from spreading malaria to humans, they say. The scientists put a new "resistance" gene into the mosquito's own DNA, using a gene editing method called Crispr. And when the GM mosquitoes mated - their offspring inherited the same resistance, PNAS journal reports. In theory, if these mosquitoes bite people, they should not be able to pass on the parasite that causes malaria.

Medical researchers have discovered a gene that increases the risk of schizophrenia, a mental illness that affects more than 2 million Americans, sometimes causing delusions and hallucinations. The finding was first reported this week in the scientific journal "Nature".