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Origins of Life Abiogenesis article in Wikipedia. The Origin of Life - Abiogenesis, a youtube video produced by Chuck Kopec.  A Simpler Origin for Life, an article by Robert Shapiro in Scientific American. The Miller-Urey Experiment article in Wikipedia. RNA and the RNA World Exploring the New RNA World, an essay by Thomas Cech published on the Nobel Prize website. RNA Video Clips from the HHMI website that include demonstrations of catalysis and interviews with Thomas Cech. A World Apart, an HHMI article about RNA World reseearch and the role of RNAs in medicine.  RNA World article in Wikipedia. Protocells The Emergence of Cells During the Origin of Life, an essay by Irene Chen published in Science.  What Came Before DNA? an article published in Discover featuring Jack Szostak and Steven Benner.  The Szostak Lab Astrobiology The National Astrobiology Institute, established by NASA to study life in the universe.  The SETI Institute, studying the origins, nature and prevalence of life in the universe.  Astrobiology: The Search for Life, a website hosted by the Exploratorium.

The Aedes aegypti mosquito is the major vector for transmission of numerous viral diseases, including yellow fever, dengue, and now, Zika. Interestingly, different subspecies of A. aegypti are known to exist in close proximity but with considerable genetic divergence between them. One major difference between a "forest" form and a "domestic" form is a strong preference in the latter subspecies for human over non-human blood biting. This difference was explored with genetic and neurophysiological approaches by a research group at Rockefeller University and published in a 2014 paper in Nature. This flipped case study uses parts of the Nature paper to focus on elements of the scientific method as well as evolutionary questions raised by the difference in biting preference between the two subspecies. Students prepare for class by watching a video that provides background information about the published study that forms the basis for the case. In class students then work in groups to develop a hypothesis, predictions and proposed experiments to test the idea of different biting preferences.

In 2005, PLoS Medicine published a now-famous paper with the attention-grabbing but exasperating title, "Why Most Published Research Findings Are False".1 It was written by John Ioannidis, MD, PhD, an American doctor from Greece, a distinguished author of about 400 peer-reviewed papers, 40 books and book chapters or so, and much more. Ioannidis is a giant, and I am really nobody to criticize.

Quintana-Murci and his colleagues also took advantage of a previously published map of areas of the human genome where Neanderthal genes are present, showing that innate immune genes are generally more likely to have been borrowed from Neanderthals than genes coding other types of proteins. Specifically, they noted that 126 innate immune genes in present-day Europeans, Asians, or both groups were among the top 5 percent of genes in the genome of each population most likely to have originated in Neanderthals. The cluster of toll-like receptor genes, encoding TLR 1, TLR 6, and TLR 10, both showed signs of having been borrowed from Neanderthals and having picked up adaptive mutations at various points in history. Meanwhile, a group led by Janet Kelso of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, used both the same previously published Neanderthal introgression map that Quintana-Murci used and a second introgression map. The researchers searched for borrowed regions of the genome that were especially long and common in present-day humans, eventually zeroing in TLR6, TLR10, and TLR1. These receptors, which detect conserved microbial proteins such as flagellin, are all encoded along the same segment of DNA on chromosome four.

Interactive tool for students to publish newspapers, brochures, or flyer/sign/posters.

The blood of young and old people differs. In an article published recently in the scientific journal Blood, a research group at Lund University in Sweden explain how they have succeeded in rejuvenating the blood of mice by reversing, or re-programming, the stem cells that produce blood.

U.S. researchers have found that Zika can attack special populations of brain cells in adult mice in the part of the brain involved in learning and memory, raising new questions about how the virus may be impacting millions of adults who have been infected with the virus. The findings, published on Thursday in the journal "Cell Stem Cell," are the first to look at whether Zika can attack the same kinds of cells in adult mice that they do in fetal mice.

In a unique twist on human genomics studies that seek to identify genetic variants linked to human disease, researchers have combined whole-exome sequencing of 50,726 adults with the individuals' long-term electronic health record (EHR) data. The effort, by researchers at the Geisinger Health System in Pennsylvania and Regeneron Genetics Center, a subsidiary of New York-based Regeneron Pharmaceuticals, has yielded novel disease-linked variants, including loss-of-function alleles. The team behind the project, called DiscovEHR, has also found that about one in 30 of the individuals harbors a deleterious genetic variant for which a screen or treatment already exists. The group's analysis is described in two papers published today (December 22) in Science.

A new study, published on Wednesday in Molecular Biology and Evolution, identifies gene variants in Inuit who live in Greenland, which may help them adapt to the cold by promoting heat-generating body fat. These variants possibly originated in the Denisovans, a group of archaic humans who, along with Neanderthals, diverged from modern humans about half a million years ago.

The Ebola epidemic that tore through West Africa in 2014 claimed 11,310 lives, far more than any previous outbreak. A combination of factors contributed to its savagery, among them a mobile population, crumbling public health systems, official neglect and hazardous burial practices. But new research suggests another impetus: The virus may have evolved a new weapon against its human hosts. In studies published on Thursday in the journal Cell, two teams of scientists report that a genetic mutation may have made Ebola more deadly by improving the virus's ability to enter human cells.

Almost every cell in your body has the same DNA sequence. So how come a heart cell is different from a brain cell? Cells use their DNA code in different ways, depending on their jobs. Just like orchestras can perform one piece of music in many different ways. A cell's combined set of changes in gene expression is called its epigenome. This week Nature publishes a slew of new data on the epigenomic landscape in lots of different cells. Learn how epigenomics works in this video. Read the latest research on epigenetics at http://www.nature.com/epigenomeroadmap

In a study published Thursday in the journal Science, they report that they've pinpointed the bit of finch DNA behind the swift transition: a gene called HMGA2. In finches, HMGA2 seems to be the primary factor in beak size - like a really good group project leader, it orchestrates the expression of a number of other genes, each of which tweaks the size of the bird's beak. The same gene also appears in dogs, horses, even humans, holding sway over body size and stature.

Why is the North American population of monarch butterflies declining? In 1999, a study published in the journal Nature suggested that a variety of genetically modified corn was killing these iconic butterflies. While it was later shown that the conditions in this study did not mirror those in the field, the results garnered a lot of media attention and many people today still believe that monarchs are being killed by GMOs. This case familiarizes students with the plight of the monarchs, encourages them to think about how to test the hypothesis that a toxin is responsible for their decline, and takes a critical look at several studies that investigated the role of Bt corn in the life cycle of monarchs. This interrupted case takes 60-90 min to complete, requires little to no science background, and can be used to explore the ecology and wildlife management of monarchs; risk assessment, toxicity, and exposure; experimental design, the scientific method, hypothesis, and critical thinking; or the relationship between science, the media and the public.

Nanotechnology Center for Learning and Teaching (NCLT) is conceived to train a nano science and technology literate workforce that can solve global problems by implementing a three-pronged strategy: 1. Publish integrated STEM instructional modules with nano-based applications; 2. Offer professional training through workshops, lectures and seminars; 3. Develop a network of multi-sector nano education communities.

The idea of a general, quick and simple blood test for a diverse range of cancers just came closer to reality with news of a new study published in Nature Medicine.

Yahoo News article 4/30 Published in the journal Nature Communications, the study claims to provide strong evidence that a mother's diet before pregnancy can permanently affect her child's lifelong health by silencing certain genes.

NIMR scientists have devised a genetic multi-colour cell labelling approach for Drosophila, called Flybow, to facilitate the visualization of cells in neural circuits with single cell resolution. The research is published in Nature Methods.

Scientists in Australia have grown the world's first kidney from stem cells - a tiny organ which could eventually help to reduce the wait for transplants. The breakthrough, published in the journal Nature Cell Biology, followed years of research and involved the transformation of human skin cells into an organoid - a functioning "mini-kidney" with a width of only a few millimetres.

In celebration of DNA Day, 23andMe took a look back at highlights in human genetics history. From the first published paper on DNA in 1953 to the first GWAS in 2005, here are some noteworthy innovations in genetics, including 23andMe company milestones.

An environmentally dependent method to excise particular genes and eliminate genetically modified organisms (GMOs) if they leave the lab, published this week (May 19) in Nature Communications, uses an inducible CRISPR/Cas9 genome-editing system to snip out vital pieces of the E. coli genome.