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Genetic studies of human disease are more challenging to perform in sub-Saharan Africa because genetic diversity is greater than in other populations. This pilot will increase our understanding of African genome variation and enable the design of large-scale genetic association studies in the region. Studies into the genetic basis of disease in European populations have made major advances in the past few years, yet similar studies in sub-Saharan Africa have been slower to develop. The high level of genetic diversity that exists in populations from sub-Saharan Africa makes genetic associations with disease more difficult to identify. The African Genome Variation Project aims to collect essential information about the structure of African genomes to provide a basic framework for genetic disease studies in Africa.

DNA from a man who lived in Ethiopia about 4,500 years ago is prompting scientists to rethink the history of human migration in Africa. Until now, the conventional wisdom had been that the first groups of modern humans left Africa roughly 70,000 years ago, stopping in the Middle East en route to Europe, Asia and beyond. Then about 3,000 years ago, a group of farmers from the Middle East and present-day Turkey came back to the Horn of Africa (probably bringing crops like wheat, barley and lentils with them).

West Africa was under the media spotlight this year-and rightly so after nearly 11,000 people died in the largest Ebola outbreak ever recorded. But although the disease flickers in and out of the public consciousness, a new study shows that another killer was nearly as deadly: snakebites.

Ebola is an infectious disease, which has become a pandemic crisis causing around 5000 deaths in 2014, with a 50% mortality rate among those who have contracted the virus. The outbreak in West Africa was first reported in March 2014, and every natural case of Ebola has been in Sub-Saharan Africa with Liberia, Sierra Leone and Guinea at the epicentre of the crisis. This key stage 3-5 resource, produced by GA Consultant and Secondary Phase Committee Co-Chair Stephen Schwab, includes classroom activities and teaching ideas, and explores geographical facts, concepts and the impact the virus has had on the communities affected.

The Ebola epidemic that tore through West Africa in 2014 claimed 11,310 lives, far more than any previous outbreak. A combination of factors contributed to its savagery, among them a mobile population, crumbling public health systems, official neglect and hazardous burial practices. But new research suggests another impetus: The virus may have evolved a new weapon against its human hosts. In studies published on Thursday in the journal Cell, two teams of scientists report that a genetic mutation may have made Ebola more deadly by improving the virus's ability to enter human cells.

The hollow Cola tree growing in a remote area of southeastern Guinea was once home to thousands of bats routinely hunted and killed by the neighborhood children. It was also a popular spot to play. A year ago, one child in particular lived within fifty meters of the tree: a two-year-old boy who died in December 2013 and later was identified as the first person in west Africa known to have developed Ebola.

Millions of people in 70 countries across Asia, Africa, and South America have been exposed to high levels of mercury as small-scale mining has proliferated over the past decade. The United Nations Environment Programme estimates that at least 10 million miners, including at least four million women and children, are working in small "artisanal" gold mines, which produce as much as 15 percent of the world's gold.

This case study is based on the 2014 Ebola epidemic that spread to multiple highly populated countries in West Africa, making it the largest and most devastating outbreak in the history of the virus. The storyline, inspired by a compilation of factual information, unfolds through a fictional narrative wherein students play the role of an infectious disease specialist in training to learn about the techniques used in the detection, diagnosis, and management of Ebola virus outbreaks. The story is presented as an interrupted "clicker case" that combines problem-based case teaching methods with simulated biological laboratory inquiry through the use of Case It, a free molecular biology software, along with the NCBI's online bioinformatics tools and databases. Students work in groups to collaboratively explore various biological and social aspects of this infectious disease outbreak. This case was developed for senior students at the secondary level and can be modified for use in an introductory biology, microbiology, or epidemiology course at the undergraduate level.

Multiple outbreaks have been reported in poultry farms and wild flocks across Europe, Africa and Asia in the past three months. While most involve strains that are currently low risk for human health, the sheer number of different types, and their presence in so many parts of the world at the same time, increases the risk of viruses mixing and mutating - and possibly jumping to people.

All living humans originated from populations of ancestors who migrated out of Africa less than 100,000 years ago. Learn how scientists have used genetic markers to trace the migration routes and origins of modern human populations.

Science denial has real, societal consequences. Denial of the link between HIV and AIDS led to more than 330,000 premature deaths in South Africa. Denial of the link between smoking and cancer has caused millions of premature deaths. Thanks to vaccination denial, preventable diseases are making a comeback.

Every year, it inflicts between 250,000 and 500,000 helpless and malnourished young people with early-life blindness. And in half of those cases, it also brings death, according to the World Health Organization. Vitamin A deficiency also puts pregnant women at risk. It's rare in developed countries, but the goal of completely eradicating vitamin A deficiency - mostly in Africa and Southeast Asia - remains unmet. Scientists are now working to genetically engineer "super" bananas that are fortified with crucial alpha- and beta-carotene, which the body converts to vitamin A.

Some of the anti-glutenists argue that we haven't eaten wheat for long enough to adapt to it as a species. Agriculture began just 12,000 years ago, not enough time for our bodies, which evolved over millions of years, primarily in Africa, to adjust. According to this theory, we're intrinsically hunter-gatherers, not bread-eaters. If exposed to gluten, some of us will develop celiac disease or gluten intolerance, or we'll simply feel lousy. Most of these assertions, however, are contradicted by significant evidence, and distract us from our actual problem: an immune system that has become overly sensitive.

The test, dubbed VirScan, and research surrounding it is the subject of a new report published in the journal Science. For the study, scientists screened sera, a part of the blood, from 569 people in the U.S., South Africa, Thailand, and Peru and tested for more than 200 types of viruses.

A study in monkeys offers the first evidence that a leading drug developed to fight Ebola works against the strain causing the current outbreak in West Africa. Six animals were infected with a very high dose of the virus and then, three days later, half were given the drug, TKM-Ebola-Makona, which was designed specifically to fight the West African strain. The monkeys that received the drug survived, but all three untreated monkeys died, researchers reported on Wednesday in the journal Nature.

Behind the unprecedented Ebola outbreak in West Africa lies a species with an incredible power to overtake its host. Zaire ebolavirus and the family of filoviruses to which it belongs owe their virulence to mechanisms that first disarm the immune response and then dismantle the vascular system.

In this lesson, students explore the fundamental mathematical concepts underlying the spread of contagious diseases. Using a simple exponential model, students compare and contrast the effects of different transmission rates on a population and develop an understanding of the nature and characteristics of exponential growth. Students can then compare their projections with actual Ebola data from West Africa, to create context for analyzing the strengths and limitations of this simplified model.

Each day malaria claims the lives of about 3,000 children in Africa-one every 30 seconds.

Sub-Saharan Africa is the most genetically diverse region in the world." The rates of susceptibility and not only whether or not someone becomes ill, but also whether or not they live or die, or even display symptoms, varies widely. The genetics of both this deadly strain of Ebola itself, and of the populations living in the affected areas, are at the forefront of the efforts by Dr. Moses as she works with Dr.Pardis Sabeti at Harvard to provide samples for genome sequencing.

A keenly observant young man named Tony Allison, working in East Africa in the 1950s, first noticed the connection and assembled the pieces of the puzzle. His story stands as the first and one of the best understood examples of natural selection, where the selective agent, adaptive mutation, and molecule involved are known-and this is in humans to boot. The protection against malaria by the sickle-cell mutation shows how evolution does not necessarily result in the best solution imaginable but proceeds by whatever means are available.