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The world is becoming more urban every day, and the process has been ongoing since the industrial revolution in the 18th century. The United Nations now estimates that 3.9 billion people live in urban centres. The rapid influx of residents is however not universal and the developed countries are already urban, but the big rise in urban population in the next 30 years is expected to be in Asia and Africa. Urbanization leads to many challenges for global health and the epidemiology of infectious diseases. New megacities can be incubators for new epidemics, and zoonotic diseases can spread in a more rapid manner and become worldwide threats. Adequate city planning and surveillance can be powerful tools to improve the global health and decrease the burden of communicable diseases.

Why elephants aren't riddled with tumors poses a weighty problem for researchers. A new study shows that the animals harbor dozens of extra copies of one of the most powerful cancer-preventing genes. These bonus genes might enable elephants to weed out potentially cancerous cells before they can grow into tumors.

Researchers in a new study at the University of Edinburgh have honed in on five of 89 independent variations in human genetics that are believed to be responsible for autoimmune conditions, from celiac disease and multiple sclerosis to rheumatoid arthritis and asthma. Understanding how these mechanisms work could help scientists to develop new treatments. The team found that a mutation in the ADAR1 gene causes a defect in an "alarm system" in cells that normally protects the body from viruses and other infections by triggering the body's immune system to fight.

A paper published today in Science Advances just might change that. By creating a reliable method of studying viruses' long evolutionary history-hitherto nearly impossible-researchers have found new evidence that strongly suggests viruses are indeed living entities.

A new study shows that gene editing using CRISPR/Cas9 technology can work in rhesus monkey embryos. The results, published in the current issue of Human Molecular Genetics, open the door for pursuing gene editing in nonhuman primates as models for new therapies, including pharmacological, gene-, and stem cell-based therapies, says Keith Latham, animal science professor at Michigan State University and lead author of the study.

This interrupted case study for the flipped classroom introduces the human microbiome from the perspective of one of its occupants, Heidi Helicobacter (Helicobacter pylori).  Heidi lives in the gut of Kristen, a college student, and discusses her fellow microbial inhabitants, functions of these various microbes, and alludes to factors that can disrupt the healthy human microbiome. Students prepare for class by viewing several brief videos and then discuss in class whether Kristen should undergo a fecal microbiota transplant to treat her Clostridium difficile infection.  A lab component has students model, using colored beads, how antibiotics can act as a selective agent for drug-resistant microbes such as C. difficile. The case concludes with Kristen about to give birth to a new baby several years later.  Students listen in as Kristen's microbes discuss the formation of the new baby's microbiome. The case has been used successfully in a general biology class and could easily be adapted for a microbiology, human physiology, ecology, or evolution course.

Scientists have discovered a previously unrecognized genus of extinct horses that roamed North America during the last ice age. The new findings are based on an analysis of ancient DNA from fossils of the enigmatic 'New World stilt-legged horse'

A new compound, discovered jointly by international pharmaceutical company Servier, headquartered in France, and Vernalis (R&D), a company based in the UK, has been shown by researchers at the Walter and Eliza Hall Institute and Servier to block a protein that is essential for the sustained growth of up to a quarter of all cancers.

Digital copy Science News

After the third time he nearly died but before the fourth, David Fajgenbaum embraced a new motto: Think it, do it. "I got out of the hospital with this profound sense of, you need to make the most of every second," he says. A former college football player with close-cropped dark hair and a firm handshake, Fajgenbaum, 31, is the picture of youthful vigor now. But that belies a frightening reality. Tomorrow the symptoms with which he's all too familiar could return, sending him to the intensive care unit (ICU) with every organ failing. 

It's one of the big mysteries of cell biology. Why do mitochondria-the oval-shaped structures that power our cells-have their own DNA, and why have they kept it when the cell itself has plenty of its own genetic material? A new study may have found an answer. Scientists think that mitochondria were once independent single-celled organisms until, more than a billion years ago, they were swallowed by larger cells. Instead of being digested, they settled down and developed a mutually beneficial relationship developed with their hosts that eventually enabled the rise of more complex life, like today's plants and animals.

Some tiny clusters of brain cells grown in a lab dish are making big news at this week's Society for Neuroscience meeting in San Diego. Known as "minibrains," these rudimentary networks of cells are small enough to fit on the head of a pin, but already are providing researchers with insights into everything from early brain development to Down syndrome, Alzheimer's and Zika.

ST. LOUIS, MISSOURI-Most of us think of Europe as the ancestral home of white people. But a new study shows that pale skin, as well as other traits such as tallness and the ability to digest milk as adults, arrived in most of the continent relatively recently. The work, presented here last week at the 84th annual meeting of the American Association of Physical Anthropologists, offers dramatic evidence of recent evolution in Europe and shows that most modern Europeans don't look much like those of 8000 years ago.

Inflammation may help you fight off invading microbes, but it can also kill you, leading to insufficient blood flow and even organ failure. A new study shows that some cancer drugs may be able to quell the excessive inflammation that occurs in conditions such as sepsis, which is responsible for more than 250,000 deaths in the United States each year.

For the third year running, Earth's thermostat broke a new record: 2016 was the warmest year since record-keeping began in 1880.

For the first time, biologists have succeeded in growing human stem cells in pig embryos, shifting from science fiction to the realm of the possible the idea of developing human organs in animals for later transplant.

Girls are less likely than boys to think that women have genius potential, a new study finds. And that stereotype can show up in kids as young as six.

Research has shown that some older people stay sharp into old age and retain the ability to recall personal experiences with just as much accuracy as their middle-aged peers. The brains of these so-called "super-agers" look distinct, too: Their gray-matter-rich outer layer, or cortex, is thicker.

New research from the Massachusetts Institute of Technology reveals that some unlikely subjects -- bacteria -- can have social structures similar to plants and animals.

In recent years, Claverie and his colleagues have discovered a host of giant viruses, which are as big as bacteria but lack characteristic cellular machinery and metabolism of those microorganisms. At least one family of these viruses likely evolved from single-celled parasites after losing essential genes, although the origins of other giant viruses remain a mystery, Claverie said.